Dion Lepp, Ph.D.

Image Dion Lepp
Biologist

Manager of Guelph RDC genomics lab

Current research and/or projects

Dr. Lepp’s work focuses on the role of the gut microbiota in health and disease, and its modulation by dietary interventions in the context of both humans and production animals.  He has also contributed significantly to our understanding of poultry diseases, such as necrotic enteritis, and has developed alternative strategies to control the disease towards limiting the use of antibiotics in poultry production. His work significantly contributes to the growth and profitability of the agri-food sector through the characterization of beneficial food attributes and mitigation of production risks.

Research and/or project statements

  • Effects of bean-based diets on human cholesterol levels, gut microbiota and associated metabolites
  • Effects of lentils on gut health and obesity
  • Development of alternative approaches to control necrotic enteritis in poultry
  • Identification of bacterial enzymes to detoxify mycotoxins

Professional activities / interests

  • Next-generation sequencing and bioinformatic analysis, focusing on microbiota analysis, bacterial pathogenomics and transcriptomics
  • Investigations of the gut microbiota and its role in health and disease of both humans and production animals
  • Understanding the pathogenesis of poultry necrotic enteritis caused by Clostridium perfringens towards developing alternatives to antibiotics

Education and awards

Ph.D. Pathobiology, University of Guelph, 2012

M.Sc. Molecular Biology and Genetics, University of Guelph, 2000

Key publications

  1. Power, K.A., Lepp, D., Zarepoor, L., Monk, J.M., Wu, W., Tsao, R., Liu, R. (2016). Dietary flaxseed modulates the colonic microenvironment in healthy C57Bl/6 male mice which may alter susceptibility to gut-associated diseases. Journal of Nutritional Biochemistry, [online] 28 61-69. http://dx.doi.org/10.1016/j.jnutbio.2015.09.028

    2016 - View publication details

  2. Monk, J.M., Lepp, D., Zhang, C.P., Wu, W., Zarepoor, L., Lu, J.T., Pauls, K.P., Tsao, R., Wood, G.A., Robinson, L.E., Power, K.A. (2016). Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation, 28 129-139. http://dx.doi.org/10.1016/j.jnutbio.2015.10.014

    2016 - View publication details

  3. Hassan, Y.I., He, J., Li, X.-Z., Lepp, D., Zhu, H., and Zhou, T. (2015). "Deoxynivalenol epimerization - A novel biotransformation with potential applications in improving crop resistance against Fusarium diseases.", 18th International Plant Protection Congress, Berlin, Germany, August 24-27, 2015, Oral presentation # OBT6, pp. 89. (Abstract)

    2015 - View publication details

  4. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Devosia limi DSM 17137, whole genome shotgun sequencing project; GenBank: LAJF00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000970435.1".

    2015 - View publication details

  5. Hassan, Y.I., Lepp, D., Li, X.-Z., and Zhou, T. (2015). "Devosia geojensis strain BD-c194, whole genome shotgun sequencing project; GenBank: JZEX00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000969415.1".

    2015 - View publication details

  6. Lepp, D., Hassan, Y.I., Li, X.-Z., and Zhou, T. (2015). "Devosia subaequoris strain HST3-14, whole genome shotgun sequencing project; GenBank: LANK00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCA_000971285.1".

    2015 - View publication details

  7. Islam, R., Yin, X., Lepp, D., Topp, E., and Diarra, M.S. (2015). "Comparative genomics of Escherichia coli isolated from soil fertilized with litter of chicken fed with or without tetracycline.", 2015 International Association of Food Protection (IAFP), Portland, Oregon, USA, July 25-28, 2015. (Abstract)

    2015 - View publication details

  8. Lepp, D., Hassan, Y.I., Li, X.-Z., and Zhou, T. (2015). "Devosia psychrophila strain Cr7-05, whole genome shotgun sequencing project; GenBank: LAPV00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000971275.1".

    2015 - View publication details

  9. Monk, J.M., Lepp, D., Wu, W., and Power, K.A. (2015). "Navy bean supplementation alters microbial activity and community structure and improves gut barrier integrity in lean and obese mice.", 8th Probiotics, Prebiotics and New Foods for Microbiota and Human Health, Rome, Italy, September 13-15, 2015.

    2015 - View publication details

  10. Lepp, D., Hassan, Y.I., Li, X.-Z., and Zhou, T. (2015). "Devosia epidermidihirudinis strain E84, whole genome shotgun sequencing project; GenBank: LANJ00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000971295.1".

    2015 - View publication details

  11. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Next-generation whole-genome sequencing platforms and factors to consider for bacterial applications.", Journal of Microbiology, Biotechnology and Food Sciences, 5(1), pp. 29-33. doi : 10.15414/jmbfs.2015.5.1.29-33

    2015 - View publication details

  12. Power, K.A., Monk, J.M., Lepp, D., Wu, W., and Pauls, K.P. (2015). "Bean supplementation enhances the colonic microenvironment and barrier integrity resulting in reduced colitis-associated tissue damage.", Bean Improvement Cooperatives 2015, Niagara Falls, ON, Canada, November 1-4, 2015.

    2015 - View publication details

  13. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Devosia chinhatensis strain IPL18, whole genome shotgun sequencing project; GenBank: JZEY00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000969445.1".

    2015 - View publication details

  14. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Devosia soli strain GH2-10, whole genome shotgun sequencing project; GenBank: LAJG00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000970455.1".

    2015 - View publication details

  15. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Genome Assemblies of Three Soil-Associated Devosia species: D. insulae, D. limi, and D. soli.", Genome Announcements, 3(3: Article e00514-15).

    2015 - View publication details

  16. Chakravarty, B., Yin, X., Lepp, D., Gagnon, N., Auffret, M., Talbot, G., and Diarra, M.S. (2015). "Antibiotic-susceptibility and genome analysis of Acinetobacter baumannii isolated from dairy cattle manures.", Guelph Food Safety Seminar Series - Food Safety: Compliance to Commitment (GFSS 11th Annual Symposium), Guelph, Ontario, Canada, October 21, 2015. (Poster)

    2015 - View publication details

  17. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Devosia insulae DS-56, whole genome shotgun sequencing project; GenBank: LAJE00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000970465.1".

    2015 - View publication details

  18. Power, K.A., Monk, J.M., Lepp, D., and Wu, W. (2015). "Bean-supplemented diet alters the colonic microenvironment to enhance barrier integrity and reduce colitis-associated inflammation and tissue damage.", FASEB: Gastrointestinal Tract XVI: GI Homeostasis: The Microbiome and the Barrier, Development, and Disease, Steamboat Springs, CO, USA, August 2-7, 2015.

    2015 - View publication details

  19. Monk, J.M., Lepp, D., Wu, W., Pauls, K.P., and Power, K.A. (2015). "Navy bean supplementation attenuates obesity-related impairments in gut barrier function.", Bean Improvement Cooperatives 2015, Niagara Falls, ON, Canada, November 1-4, 2015, Oral presentation.

    2015 - View publication details

  20. Monk, J.M., Lepp, D., Zhang, C., Wu, W., Wood, G.A., Robinson, L.E., and Power, K.A. (2015). "Cranberry beans alter gut micriobial activity and community structure, improve gut health and mitigate colitis severity.", Canadian Nutrition Society Annual Meeting, Winnipeg, Canada, May 28-30, 2015. (Abstract)

    2015 - View publication details

Research facility

93 Stone Road West
Guelph, ON N1G 5C9
Canada

Affiliations

  • Adjunct Faculty, Department of Pathobiology, University of Guelph
  • Adjunct Professor, Department of Animal Science, University of Manitoba

Language

English