Dion Lepp, Ph.D.

Image Dion Lepp
Biologist

Manager of Guelph RDC genomics lab

Current research and/or projects

Dr. Lepp’s work focuses on the role of the gut microbiota in health and disease, and its modulation by dietary interventions in the context of both humans and production animals.  He has also contributed significantly to our understanding of poultry diseases, such as necrotic enteritis, and has developed alternative strategies to control the disease towards limiting the use of antibiotics in poultry production. His work significantly contributes to the growth and profitability of the agri-food sector through the characterization of beneficial food attributes and mitigation of production risks.

Research and/or project statements

  • Effects of bean-based diets on human cholesterol levels, gut microbiota and associated metabolites
  • Effects of lentils on gut health and obesity
  • Development of alternative approaches to control necrotic enteritis in poultry
  • Identification of bacterial enzymes to detoxify mycotoxins

Professional activities / interests

  • Next-generation sequencing and bioinformatic analysis, focusing on microbiota analysis, bacterial pathogenomics and transcriptomics
  • Investigations of the gut microbiota and its role in health and disease of both humans and production animals
  • Understanding the pathogenesis of poultry necrotic enteritis caused by Clostridium perfringens towards developing alternatives to antibiotics

Education and awards

Ph.D. Pathobiology, University of Guelph, 2012

M.Sc. Molecular Biology and Genetics, University of Guelph, 2000

Key publications

  1. 2020 Poultry Science Association Annual Meeting, Webinar Series, July 20-23.

    2020 - View publication details

  2. 2020 Poultry Science Association Annual Meeting, Webinar Series, July 20-23.

    2020 - View publication details

  3. 2020 Animal Nutrition Conference of Canada, Webinar Series, May 26-June 11.

    2020 - View publication details

  4. Das, Q., Lepp, D., Yin, X., Ross, K., McCallum, J.L., Warriner, K., Marcone, M.F., Diarra, M.S. (2019). Transcriptional profiling of Salmonella enterica serovar Enteritidis exposed to ethanolic extract of organic cranberry pomace, 14(7), http://dx.doi.org/10.1371/journal.pone.0219163

    2019 - View publication details

  5. Taggar, G., Rehman, M.A., Yin, X., Lepp, D., Ziebell, K., Handyside, P., Boerlin, P., Diarra, M.S. (2018). Antimicrobial-resistant E. Coli from surface waters in southwest Ontario dairy farms, 47(5), 1068-1078. http://dx.doi.org/10.2134/jeq2018.04.0139

    2018 - View publication details

  6. Carere, J., Hassan, Y.I., Lepp, D., Zhou, T. (2018). The identification of DepB: An enzyme responsible for the final detoxification step in the deoxynivalenol epimerization pathway in devosia mutans 17-2-E-8, 9(JUL), http://dx.doi.org/10.3389/fmicb.2018.01573

    2018 - View publication details

  7. The 10th Clostpath; Aug. 7-10, Ann Arbor, Michigan, USA.

    2017 - View publication details

  8. ASM Microbe-2017; June 1-5, New Orleans, LA, USA.

    2017 - View publication details

  9. Yu, Q., Lepp, D., Gohari, I.M., Wu, T., Zhou, H., Yin, X., Yu, H., Prescott, J.F., Nie, S.P., Xie, M.Y., Gong, J. (2017). The Agr-like quorum sensing system is required for pathogenesis of necrotic enteritis caused by Clostridium perfringens in poultry, 85(6), http://dx.doi.org/10.1128/IAI.00975-16

    2017 - View publication details

  10. Rafiq Ahad, Ting Zhou, Dion Lepp and K. Peter Pauls. 2017. Microbial detoxification of eleven food and feed contaminating trichothecene mycotoxins. BMC Biotechnology. DOI 10.1186/s12896-017-0352-7

    2017 - View publication details

  11. Ahad R, Zhou T, Lepp D, Pauls KP. 2017. Draft genome sequence of Citrobacter freundii strain A47, resistant to the mycotoxin deoxynivalenol. Genome Announc 5:e00019-17.

    2017 - View publication details

  12. Lepp, D., Hassan, Y.I., and Zhou, T. (2016). "Comparative genomics of Devosia isolates involved in the biotransformation of the mycotoxin deoxynivalenol (http://asmmicrobe.org/images/AbstractsUpdated.pdf).", ASM Microbe 2016, Boston, USA, 16-20 June, 2016, Poster Presentation LB008. (Abstract)

    2016 - View publication details

  13. 2016 Ontario Ministry of Agriculture, Food and Rural Affairs - FOOD SAFETY RESEARCH FORUM; October 26, Guelph, Ontario.

    2016 - View publication details

  14. 10th Joint INRA-Rowett Symposium "Gut Microbiology: 20 years and counting…"; June 20-23, Clermont-Ferrand, France.

    2016 - View publication details

  15. Prescott, J.F., Parreira, V.R., Gohari, I.M., Lepp, D., and Gong, J. (2016). "The pathogenesis of necrotic enteritis in chickens: What we know and what we need to know.", Avian Pathology. doi : 10.1080/03079457.2016.1139688

    2016 - View publication details

  16. Power, K.A., Lepp, D., Zarepoor, L., Monk, J.M., Wu, W., Tsao, R., Liu, R. (2016). Dietary flaxseed modulates the colonic microenvironment in healthy C57Bl/6 male mice which may alter susceptibility to gut-associated diseases, 28 61-69. http://dx.doi.org/10.1016/j.jnutbio.2015.09.028

    2016 - View publication details

  17. Monk, J.M., Lepp, D., Zhang, C.P., Wu, W., Zarepoor, L., Lu, J.T., Pauls, K.P., Tsao, R., Wood, G.A., Robinson, L.E., Power, K.A. (2016). Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation, 28 129-139. http://dx.doi.org/10.1016/j.jnutbio.2015.10.014

    2016 - View publication details

  18. Chakravarty, B., Yin, X., Lepp, D., Gagnon, N., Auffret, M., Talbot, G., and Diarra, M.S. (2015). "Antibiotic-susceptibility and genome analysis of Acinetobacter baumannii isolated from dairy cattle manures.", Guelph Food Safety Seminar Series - Food Safety: Compliance to Commitment (GFSS 11th Annual Symposium), Guelph, Ontario, Canada, October 21, 2015. (Poster)

    2015 - View publication details

  19. Hassan, Y.I., Lepp, D., and Zhou, T. (2015). "Devosia insulae DS-56, whole genome shotgun sequencing project; GenBank: LAJE00000000.1. http://www.ncbi.nlm.nih.gov/assembly/GCF_000970465.1".

    2015 - View publication details

  20. Power, K.A., Monk, J.M., Lepp, D., and Wu, W. (2015). "Bean-supplemented diet alters the colonic microenvironment to enhance barrier integrity and reduce colitis-associated inflammation and tissue damage.", FASEB: Gastrointestinal Tract XVI: GI Homeostasis: The Microbiome and the Barrier, Development, and Disease, Steamboat Springs, CO, USA, August 2-7, 2015.

    2015 - View publication details

Research facility

93 Stone Road West
Guelph, ON N1G 5C9
Canada

Affiliations

  • Adjunct Faculty, Department of Pathobiology, University of Guelph
  • Adjunct Professor, Department of Animal Science, University of Manitoba

Language

English