Wenjun Zhu
Conception, réalisation de travaux de recherche et d’analyse des renseignements relatifs aux enquêtes, aux expériences et aux essais contrôlés en laboratoire.
Recherche et / ou projets en cours
Développement du diagnostic rapide et de contre-mesures thérapeutiques contre les agents pathogènes zoonotiques à haut risque (virus Nipah et Ebola)
Énoncés de recherches/projets
Étude des mécanismes de pathogénicité élevée des virus Ebola et Marburg;
Développement du diagnostic rapide et de contre-mesures thérapeutiques contre les agents pathogènes zoonotiques à haut risque
Prix et études
Études :
Docteur en philosophie (Neuropharmacologie), 2013, Collège de pharmacie, Université du Manitoba, Canada
Maîtrise en philosophie (Science pharmaceutique), 2006, Pharmacy School, Aston University, Royaume-Uni (R.-U.)
Baccalauréat ès sciences (Pharmacie), 1998, Collège de pharmacie, Université pharmaceutique de Shenyang, Chine
Prix :
Bourse de recherche scientifique (2018-2020) du Conseil de recherches en sciences naturelles et en génie du Canada (CRSNG)
Prix spéciaux pour études de cycles supérieurs (2011-2012)
Prix Robert Charles Armatage (2011)
Prix du Groupe Financier Banque TD (2010)
Bourses d’études canadiennes du millénaire (2006-2010)
Bourse d’études du Manitoba (2007-2008)
Poste d’assistant à la recherche, Université du Manitoba (2006-2010)
Poste d’assistant à la recherche, The University of Texas at Austin (2003)
Principales publications
Yang M, Zhu W, Truong T, Pickering B, Babiuk S, Kobasa D, Banadyga L. Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays. Viruses. 2022; 14(8):1657. https://doi.org/10.3390/v14081657
Zhu W, Liu G, Cao W, He S, Leung A, Ströher U, Fairchild MJ, Nichols R, Crowell J, Fusco J, Banadyga L. A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease. Vaccines. 2022; 10(7):1004. https://doi.org/10.3390/vaccines10071004
Liu G, Cao W, Salawudeen A, Zhu W, Emeterio K, Safronetz D, Banadyga L. Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector. Pathogens. 2021; 10(9):1092.
Schiffman Z, Liu G, Wenguang Cao, Zhu W, Emeterio K, Qiu X, Banadyga L. The Ferret as a Model for Filovirus Pathogenesis and Countermeasure Evaluation, ILAR Journal, 2021;, ilab011.
Schiffman Z, Yan F, He S, Tierney K, Zhu W, Emeterio K, Zhang H, Banadyga L, Qiu X. Taï Forest Virus Does Not Cause Lethal Disease in Ferrets. Microorganisms. 2021; 9(2):213.
Banadyga L, Zhu W, Kailasan S, et al. Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop. mBio. 2021;12(1):e01438-20.
Zhu W, Banadyga L, Emeterio K, Wong G, Qiu X. (2019). The roles of Ebola virus soluble glycoprotein in replication, pathogenesis, and countermeasure development. Viruses, 11(11), 999.
Ao Z, Wang L, Mendoza E J, Cheng K, Zhu W, Cohen E A, Fowke K, Qiu X, Kobinger G, Yao X. (2019). Incorporation of Ebola glycoprotein into HIV particles facilitates dendritic cell and macrophage targeting and enhances HIV-specific immune responses. PloS one, 14(5), e0216949. doi:10.1371/journal.pone.0216949
Zhang X, Yan F, Tang K, Chen Q, Guo J, Zhu W, He S, Banadyga L, Qiu X, Guo Y. (2019). Identification of a clinical compound losmapimod that blocks Lassa virus entry. Antiviral Res. 2019 Jul; 167:68-77. doi: 10.1016/j.antiviral.2019.03.014. Epub 2019 Apr 4.
Brannan JM, He S, Howell KA, Zhu W, Vu H, Shulenin S, Kailasan S, Raina H, Wong G, Rahim MN, Banadyga L, Tierney K, Zhao X, Li Y, Holtsberg FW, Dye JM, Qiu X and Aman J. (2019). Postexposure immunotherapy of Ebola, Sudan, and Marburg virus infection in nonhuman primates. Nature Communications. 10(1): 105.
Bornholdt Z A, Herbert AS, Mire CE, He S, Cross RW, Wec A, Abelson DM, Geisbert JB, James RM, Rahim MN, Zhu W, Borisevich V, Banadyga L, Gunn BM, Agans KN, Goodwin E, Tierney K, Shestowsky WS, Bohorov O, Bohorova N, Velasco J, Ailor E, Kim D, Pauly MH, Whaley KJ, Alter G, Walker LM, Chandran K, Zeitlin L, Qiu X, Geisbert TW and Dye JM. (2019). A two-antibody pan-ebola virus cocktail confers broad therapeutic protection in nonhuman primates. Cell Host and Microbe. 25(1): 49-58.
Banadyga L, Siragam V, Zhu W, He S, Cheng K, Qiu X. (2019). The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated with Monoclonal Antibodies. Open Forum Infectious Diseases.
Wec AZ, Bornholdt ZA, He S, Herbert AS, Goodwin E, Wirchnianski AS, Gunn BM, Zhang Z, Zhu W, Liu G, Abelson DM, Moyer CL, Jangra RK, James RM, Bakken RR, Bohorova N, Bohorov O, Kim DH, Pauly MH, Velasco J, Bortz RH 3rd, Whaley KJ, Goldstein T, Anthony SJ, Alter G, Walker LM, Dye JM, Zeitlin L, Qiu X, Chandran K. (2019). Development of a Human Antibody Cocktail that Deploys Multiple Functions toConfer Pan-Ebolavirus Protection. Cell Host and Microbe. 25(1): 39-48.
Zhu W, Zhang Z, He S, Wong G, Banadyga L, Qiu X. (2018). Successful treatment of Marburg virus with orally administrated T-705 (Favipiravir) in a mouse model. Antiviral research. 151: 39-49.
Wang H, Wong G, Zhu W, He S, Zhao Y, Yan F, Rahim MN, Bi Y, Zhang Z, Cheng K, Jin H, Cao Z, Zheng X, Gai W, Bai J, Chen W, Zou Y, Gao Y, Gao GF, Yang S, Xia X and Qiu X. (2018). Equine-origin immunoglobulin fragments protects nonhuman primates from Ebola virus disease. Journal of Virology. Epub Ahead of Print: JVI.01548-18.
Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W. (2018). Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discovery. 4:31
Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A. (2018). Computer-aided discovery and characterization of novel Ebola virus inhibitors. Journal of Medicinal Chemistry. 61(8): 3582-3594.
Wong G, Cao W, He S, Zhu W, Zhang Z, Ebihara H, Qiu X. (2018). Development and characterization of a guinea pig model for Marburg virus. Zoological Research. 39(1): 32-41.
Rahim MN, Zhang Z, He S, Zhu W, Banadyga L, Safronetz D, Qiu X. (2018). Postexposure protective efficacy of T-705 (Favipiravir) against Sudan virus infection in guinea pigs. The Journal of Infectious Diseases.
Tang K, He S, Zhang X, Guo J, Chen Q, Yan F, Banadyga L, Zhu W, Qiu X, Guo Y. (2018). Tangeretin, an extract from Citrus peels, blocks cellular entry of arenaviruses that cause viral hemorrhagic fever. Antiviral Research. 160: 87-93.
Wong G, He S, Leung A, Cao W, Bi Y, Zhang Z, Zhu W, Wang L, Zhao Y, Cheng K, Liu D, Liu W, Kobasa D, Gao GF, Qiu X. (2018). Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity. Journal of Virology. 93(1): e01098-18.
Wec AZ, Herbert AS, Murin CD, Nyakatura EK, Abelson DM, Fels JM, He S, James RM, de La Vega MA, Zhu W, Bakken RR, Goodwin E, Turner HL, Jangra RK, Zeitlin L, Qiu X, Lai JR, Walker LM, Ward AB, Dye JM, Chandran K, Bornholdt ZA. (2017). Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses. Cell. 169(5): 878-890.
Zhu W, Acosta C, MacNeil B, Klonisch T, Cortes C, Doupe C, Gong Y, Namaka M. (2014). Spinal Cord Brain Derived Neurotrophic Factor (BDNF) Responsive Cells in an Experimental Autoimmune Encephalomyelitis (EAE) Model of Multiple Sclerosis (MS): Implications in Myelin Repair. Research in Immunology: An International Journal, Article ID 612406, 19 pages, DOI: 10.5171/2014.612406.
Zhu W, Acosta C, MacNeil B, Cortes C, Intrater H, Gong Y, Namaka M. (2012). Elevated Expression of Fractalkine (CX3CL1) and Fractalkine receptor (CX3CR1) in the Dorsal Root Ganglia (DRG) and Spinal Cord (SC) in Experimental Autoimmune Encephalomyelitis (EAE): Implications in Multiple Sclerosis (MS) – Induced Neuropathic Pain (NPP). BioMed Research International, Volume 2013, Article ID 480702.
Begum F, Zhu W, Cortes C, MacNeil B, Namaka M. (2013). Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis. Journal of Neuroimmune Pharmacology. 8(3): 677-690.
Zhu W, Frost E, Begum F, et al. (2012). The role of dorsal root ganglia activation and brain derived neurotrophic factor in multiple sclerosis. Journal of Cellular and Molecular Medicine. 16(8):1856-1865.
Zhu W, Le Dorze JA, Prout M, et al. (2010). An Overview of Relapsing Remitting Multiple Sclerosis (RRMS) and Current Treatment Options. Pharmacy Practice. 2010 Nov.
Begum F, Zhu W, Namaka M, Frost E. (2010). A novel decalcification method for adult rodent bone for histological analysis of peripheral-central nervous system connections. Journal of Neuroscience Methods. 2010; 187(1): 59-66.
Vora P, Pillai P P, Zhu W, Mustapha J, Namaka M P, Fros, E E. (2011). Differential effects of growth factors on oligodendrocyte progenitor migration. European Journal of Cell Biology. 2011; 90(8):649-656.
Melanson M, Miao P, Eisenstat D, Gong Y, Gu X, Au K, Zhu W, Begum F, Frost EE, Namaka M. (2009). Experimental autoimmune encephalomyelities- induced upregulation of tumor necrosis factor-alpha in the dorsal root ganglia. Multiple Sclerosis. 2009; 15(10):1135-1145.