G. Douglas Inglis

Chercheur

Microbiologie entérique et santé intestinale

Agriculture et Agroalimentaire Canada

Recherche et / ou projets en cours

  • Taboada EN (CP), Inglis GD (CP), Carrillo C, Wong A, Finley R, Boras V, Chui L. Genome Alberta (Alberta Applied Agricultural Genomics Program). Projet : Génomique comparative des souches de Campylobacter courantes dans la production de volaille au Canada qui sont associées à des maladies humaines : identification de biomarqueurs pertinents à l’élaboration de stratégies d’atténuation ciblées (titre officiel : Comparative genomics of Campylobacter strains prevalent in Canadian poultry production associated with human disease: identification of biomarkers relevant to the development of targeted mitigation strategies). 2019-2020.
  • Inglis GD (CP), Uwiera RRE, Abbott DW, Brumer H, Selinger LB, Metz G, Bruce H. Conseil de recherches avicoles du Canada (grappe des sciences avicoles). Projet: Atténuation de l’inflammation intestinale pour la santé des volailles et de la production avicole (titre officiel: Mitigation of intestinal inflammation for poultry and production health). 2018-2023.
  • Inglis GD (CP), Taboada EN, Uwiera RRE, Abbott DW. Conseil de recherches avicoles du Canada (grappe des sciences avicoles). Projet: Atténuation rationnelle des souches pertinentes de Campylobacter jejuni dans la filière de production de poulets de chair (titre officiel: Rationale-based mitigation of relevant Campylobacter jejuni strains within the broiler production continuum). 2018-2023.
  • Abbott DW (CP), Inglis GD, Slominski B, Thomas D. Alberta Agriculture Funding Consortium. Projet: Pipeline de recherche pour la mise au point d’enzymes fibrolytiques sur mesure pour améliorer la digestibilité du tourteau de canola destiné aux animaux d’élevage monogastriques (titre officiel: Discovery pipeline for rapid development of tailored fibrolytic enzymes that improve the digestibility of canola meal for monogastric livestock)" 2018-2020.
  • Kalmokoff M (CP), Inglis GD (co-CP), Bezanson G, Ells T, Jones T, Guévremont É, Schwartzkopf-Genswein K, Hebb D, Eberl H, Uwiera R, Brooks S, Selinger B. Agriculture et Agroalimentaire Canada. Projet: Mise au point d’une culture d’exclusion compétitive ciblant Escherichia coli O157:H7 chez les bovins (titre officiel: Development of a competitive exclusion culture targeting Escherichia coli O157:H7 in cattle). 2018-2019.
  • Brumer H (CP), Inglis GD (co-CP), Abbott DW, Uwiera RRE. Canadian Glycomics Network (GlycoNet). Projet: Vectorisation de médicaments par oligosaccharides pour le traitement de maladies inflammatoires entériques chez l'homme et le bétail (titre officiel: Glyco-caged drug delivery to treat enteric inflammatory diseases in humans and livestock). 2017-2019.
  • Inglis GD (CP), Abbott DW, Thomas D, Selinger LB, Uwiera T, Kastelic JP, Taboada E, Carrillo C, Amoako K, Waddington L, Uwiera RRE, Selinger LB, Boras VF, Suttorp VV. Agriculture et Agroalimentaire Canada. Projet : Innovations visant à atténuer les sous-types de Campylobacter jejuni dans la chaîne d'approvisionnement de la volaille (titre officiel: Novel Innovations to mitigate Campylobacter jejuni subtypes in the poultry supply chain). 2016-2019.
  • Abbott DW (CP), Inglis GD (co-CP), Thomas D, Gilbert H, Martens E, Uwiera R, Uwiera T, Kastelic J, Metz G, Selinger LB, Koegler DP. Agriculture et Agroalimentaire Canada. Projet : Solutions non antimicrobiennes pour améliorer la santé immunitaire innée, la résistance à la colonisation et le rendement environnemental des porcs (titre officiel: Non-antimicrobial alternatives for improving innate immune health, colonization resistance, and environmental performance of swine). 2016-2019.
  • Uwiera RRE, Inglis GD (co-CP), Abbott DW, Selinger LB, Uwiera T, Kastelic JP, Boras VF, Koegler DP. Alberta Livestock and Meat Agency. Projet : Nouvelle thérapeutique sans antibiotiques pour la prise en charge des maladies inflammatoires aiguës et chroniques chez les mammifères d’élevage (titre officiel: A novel non-antibiotic therapeutic innovation for acute and chronic inflammatory enteric disease management in mammalian livestock). 2016-2020.

Énoncés de recherches/projets

  • Microbiologie entérique
  • Santé intestinale
  • Immunologie
  • Solutions de rechange aux antibiotiques pour la production animale

Prix et études

  • Ph.D., microbiologie, Université Simon Fraser (1996)
  • M.Sc. (distinction), microbiologie, Université de Guelph (1989)
  • B.Sc. (distinction), microbiologie, Université de l'Alberta (1985)

Principales publications

Pour une liste complète de publications, visitez : AAC en ligne

  • Lange M, Uwiera RRE, Inglis GD. 2019. Housing gnotobiotic mice in conventional animal facilities. Comparative Protocols in Mouse Biology 15:e59 (PMID: 30645047) (DOI: 10.1002/cpmo.59).
  • Inglis GD, Duke GM, Goettel MS, Kabaluk JT, Ortega-Polo R. 2019. Biogeography and genotypic diversity of Metarhizium brunneum and Metarhizium robertsii in northwestern North American soils. Canadian Journal of Microbiology (in press). (PMID: 30532988) (DOI: 10.1139/cjm-2018-0297).
  • Varankovich N, Grigoryan A, Brown K, Inglis GD, Uwiera RRE, Nickerson MT, Korber DR. 2018. Pea-protein alginate encapsulation adversely affects development of clinical signs of Citrobacter rodentium-induced colitis in mice treated with probiotics. Canadian Journal of Microbiology 64:1-17 (PMID: 29958098) (DOI: 10.1139/cjm-2018-0166).
  • Inglis GD, Zaytsoff SJM, Selinger LB, Taboada EN, Uwiera RRE. 2018. Therapeutic administration of enrofloxacin in mice does not select for fluoroquinolone resistance in Campylobacter jejuni. Canadian Journal of Microbiology 64:1-14 (PMID: 29750889) (DOI: 10.1139/cjm-2017-0741).
  • Webb AL, Selinger LB, Taboada EN, Inglis GD. 2018. Subtype-specific selection for resistance to fluoroquinolones but not to tetracycline occurs in Campylobacter jejuni from beef cattle in confined feeding operations in Southern Alberta, Canada. Applied and Environmental Microbiology 84:e02713-17 (PMID: 29352087) (DOI: 10.1128/AEM.02713-17).
  • Brown K, Abbott DW, Uwiera RRE, Inglis GD. 2018. Removal of the cecum affects intestinal fermentation, enteric bacterial community structure, and acute colitis in mice. Gut Microbes 9:1-18 (PMID: 29227180) (DOI: 10.1080/19490976.2017.1408763).
  • Pluvinage B, Grondin JM, Amundsen C, Klassen L, Moote PE, Xiao Y, Thomas D, Pudlo NA, Anele A, Martens EC, Inglis GD, Uwiera RRE, Boraston AB, Abbott DW. 2018. Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont. Nature Communications 9:1043 (PMID: 29535379) (DOI: 0.1038/s41467-018-03366-x).
  • Abbott DW, Jones DR, Thomas D, Alger N, Ghavidel A, Inglis GD. 2018. SACCHARIS: An automated pipeline to inform discovery of carbohydrate active enzyme activities within polyspecific families and de novo sequence datasets. Biotechnology for Biofuels 11:27 (15 pages) (PMID: 29441125) (DOI: 10.1186/s13068-018-1027-x).
  • Jiminez J, Uwiera TC, Abbott DW, Uwiera RRE, Inglis GD. 2017. Butyrate supplementation at high concentrations alters enteric bacterial communities and reduces intestinal inflammation in mice infected with Citrobacter rodentium. mSphere e00243-17 (PMID: 28861518) (DOI: 10.1128/mSphere.00243-17).
  • Clarke ST, Brooks SPJ, Inglis GD, Yanke LJ, Green J, Petronella N, Ramdath DD, Bercik P, Green-Johnson JM, Kalmokoff M. 2017. Impact of β2-1 fructan on faecal community change: results from a placebo-controlled, randomised, double-blinded, crossover study in healthy adults. British Journal of Nutrition 118:441-53 (PMID: 28954640) (DOI: 10.1017/S0007114517002318).
  • Golubov A, Byeon B, Woycick R, Inglis GD, Kovalchuk I. 2017. Transcriptome of Arabidopsis thaliana plants treated with the human pathogen Campylobacter jejuni. Biocatalysis and Agricultural Biotechnology 11:259-67 (DOI: 10.1016/j.bcab.2017.07.016).
  • Buchanan CJ, Webb AL, Mutschall SK, Kruczkiewicz P, Barker DOR, Hetman BM, Gannon VPJ, Abbott DW, Thomas JE, Inglis GD, Taboada EN. 2017. A genome-wide association study to identify diagnostic markers for human pathogenic Campylobacter jejuni strains. Frontiers in Microbiology 8: Article 1224 (PMID: 28713351) (DOI: 10.3389/fmicb.2017.01224).
  • Webb AL, Taboada EN, Selinger LB, Boras VF, Inglis GD. 2017. Prevalence and diversity of waterborne Arcobacter butzleri in southwestern Alberta, Canada. Canadian Journal of Microbiology 63:330-40 (PMID: 28177789) (DOI: 10.1139/cjm-2016-0745)
  • Brown K, Uwiera RR, Kalmokoff ML, Brooks SP, Inglis GD. 2017. Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives. International Journal of Antimicrobial Agents 49:12-24 (PMID: 27717740) (DOI: 10.1016/j.ijantimicag.2016.08.006).
  • Leblanc D, Inglis GD, Boras VF, Brassard J, Houde A. 2017. The prevalence of enteric RNA viruses in stools from diarrheic and non-diarrheic people in southwestern Alberta, Canada. Archives of Virology 162:117-28 (PMID: 27686073) (DOI: 10.1007/s00705-016-3063-9).
  • Holani R, Shah C, Haji Q, Inglis GD, Uwiera RR, Cobo ER. 2016. Proline-arginine rich (PR-39) cathelicidin: structure, expression and functional implication in intestinal health. Comparative Immunology, Microbiology and Infectious Diseases. 49:95-101 (PMID: 27865272) (DOI: 10.1016/j.cimid.2016.10.004).
  • Webb AL, Boras VF, Kruczkiewicz P, Selinger LB, Taboada EN, Inglis GD. 2016. Comparative detection and quantification of Arcobacter butzleri in stools from diarrheic and nondiarrheic people in southwestern Alberta, Canada. Journal of Clinical Microbiology. 54:1082-8 (PMID: 26865686) (DOI: 10.1128/JCM.03202-15).
  • Webb AL, Taboada EN, Selinger LB, Boras VF, Inglis GD. 2016. Efficacy of wastewater treatment on Arcobacter butzleri density and strain diversity. Water Research. 105:291-6 (PMID: 27636152) (DOI: 10.1016/j.watres.2016.09.003).
  • Jiminez JA, Uwiera TC, Abbott DW, Uwiera RR, Inglis GD. 2016. Impacts of resistant starch and wheat bran consumption on enteric inflammation in relation to colonic bacterial community structures and short-chain fatty acid concentrations in mice. Gut Pathogens. 2016 8:67 (20 pages) (PMID: 28031748) (DOI: 10.1186/s13099-016-0149-6).
  • Brown K, Zaytsoff SJ, Uwiera RR, Inglis GD. 2016. Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota. Scientific Reports 6, 6:38377 (13 pages) (PMID: 27929072) (DOI: 10.1038/srep38377).
  • Clarke ST, Green-Johnson JM, Brooks SP, Ramdath DD, Bercik P, Avila C, Inglis GD, Green J, Yanke LJ, Selinger LB, Kalmokoff M. 2016. β2-1 fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults. British Journal of Nutrition 115:1748-59 (PMID:26987626) (DOI: 10.1017/S0007114516000908).
  • Jiminez J, Uwiera TC, Inglis GD, Uwiera RRE. 2015. Animal models to study acute and chronic intestinal inflammation in mammals. Gut Pathogens 7:29 (31 pages) (PMID: 26561503) (DOI: 10.1186/s13099-015-0076-y).
  • Brassard J, Gagné MJ, Leblanc D, Poitras É, Alain Houde A, Boras VF, Inglis GD. 2015. Association of age and gender with Torque teno virus detection in stools from diarrheic and non-diarrheic people. Journal of Clinical Virology 72:55-59 (PMID: 26401905) (DOI: 10.1016/j.jcv.2015.08.020).
  • Webb AL, Kruczkiewicz P, Selinger LB, Inglis GD, Taboada EN. 2015. Development of a comparative genomic fingerprinting assay for rapid and high resolution genotyping of Arcobacter butzleri. BMC Microbiology 15:94 (12 pages) (PMID: 25947176) (DOI: 10.1186/s12866-015-0426-4).
  • Thomas DK, Lone AG, Selinger LB, Taboada EN, Uwiera RRE, DW Abbott, Inglis GD. 2014. Comparative genomic variation within Campylobacter jejuni NCTC 11168 in human and murine hosts. PLoS One 9: e88229 (11 pages) (PMID: 24516617) (DOI: 10.1371/journal.pone.0088229).
  • Lone AG, Selinger LB, Uwiera RRE, Yu Y, Inglis GD. 2013. Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammation. PLoS One 8:e75325 (15 pages) (PMID: 24066174) (DOI: 10.1371/journal.pone.0075325).
  • Reti KL, Thomas MC**, Yanke LJ, Selinger LB, Inglis GD. 2013. Effect of antimicrobial growth promoters on the intestinal microbiota of beef cattle. Gut Pathogens 5:8 (16 pages) (PMID: 23578222) (DOI: 10.1186/1757-4749-5-8).
  • Thomas MC, Selinger LB, Inglis GD. 2012. Seasonal diversity of planktonic protists in Southwestern Alberta rivers over a 1-year period as revealed by terminal restriction fragment length polymorphism and 18S rRNA gene library analyses. Applied and Environmental Microbiology 47:5653-60 (PMID: 22685143) (DOI: 10.1128/AEM.00237-12).
  • Puhl NJ, Uwiera RRA, Yanke LJ, Selinger LB, Inglis GD. 2012. Broad‑spectrum antibiotics conspicuously affect community profiles and richness, but not the density of bacterial cells associated with mucosa in the large and small intestines of mice. Anaerobe 18:67-75 (DOI: 10.1016/j.anaerobe.2011.12.007).
  • Inglis GD, Thomas MC*, Thomas DK, Kalmokoff ML, Brooks SPJ, Selinger LB. 2012. Molecular methods to measure intestinal bacteria: a review. Journal of AOAC International 95:5-23 (PMID: 22468337) (DOI: 10.5740/jaoacint.SGE_Inglis).
  • Costa E, Uwiera RRE, Kastelic JP, Selinger LB, Inglis GD. 2011. Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses. Gut Pathogens 3:14 (15 pages) (PMID: 21943280) (DOI: 10.1186/1757-4749-3-14).
  • Inglis GD, Yanke LJ, Selinger LB. 2011. Cutinolytic esterase activity of bacteria isolated from mixed-plant compost and characterization of a cutinase gene from Pseudomonas pseudoalcaligenes. Canadian Journal of Microbiology 57:902-13 (PMID: 22029433) (DOI: 10.1139/w11-083).
  • Thomas MC, Thomas DK, Selinger LB, Inglis GD. 2011. SPYDER: a new method for in silico design and assessment of 16S rDNA primers for molecular microbial ecology. FEMS Microbiology Letters. 320:152‑9 (PMID: 21554380) (DOI: 10.1111/j.1574-6968.2011.02302.x).
  • Kalischuk LD, Inglis GD. 2011. Comparative genotypic and pathogenic examination of Campylobacter concisus isolates from diarrheic and non‑diarrheic humans. BMC Microbiology 11:53 (13 pages) (PMID: 21406111) (DOI: 10.1186/1471-2180-11-53).
  •  Xu S, Inglis GD, Reuter T, Clark OG, Belosevic M, McAllister TA, Leonard JJ. 2011. Biodegradation of specified risk material and characterization of actinobacterial communities in laboratory‑scale composters. Biodegradation 22:1029-43 (PMID: 21360115) (DOI: 10.1007/s10532-011-9461-5).
  • Inglis GD, Boras VF, Houde A. 2011. Enteric campylobacteria and RNA viruses associated with healthy and diarrheic humans in the Chinook Heath Region of southwestern Alberta. Journal of Clinical Microbiology 49:209-19 (PMID: 21106791) (DOI: 10.1128/JCM.01220-10).
  • Kalischuk LD, Legget F, Inglis GD. 2010. Campylobacter jejuni induces transcytosis of commensal bacteria across the intestinal epithelium through M-like cells. Gut Pathogens 2:14 (7 pages) (PMID: 21040540) (DOI: 10.1186/1757-4749-2-14).
  • Inglis GD, Kastelic JP, Uwiera RRE. 2010. Catheterization of intestinal loops in ruminants does not adversely affect loop function. Comparative Medicine 60:469-78 (PMID: 21262134) (DOI: 10.3791/1301).
  • Inglis GD, McAllister TA, Larney FJ, Topp E. 2010. Prolonged survival of Campylobacter species in bovine manure compost. Applied and Environmental Microbiology 76:1110‑9 (PMID: 20023098) (DOI: 10.1128/AEM.01902-09).

Affiliations

  • Professeur Adjoint, Université de Lethbridge, départements des Sciences biologiques et des Neurosciences
  • Professeur Adjoint, Université de l'Alberta, Département des sciences agricoles, alimentaires et nutritionnelles
  • Professeur Adjoint, Université de Calgary, Faculté de médecine vétérinaire

Langue

Anglais