Dr. Carolyn Fitzsimmons

Image Carolyn Fitzsimmons
Research Scientist, Bovine Genetics

Dr Fitzsimmons is co-located at the University of Alberta and works in the areas of beef production and molecular genetics. She has a particular interest in the genetic control of residual feed intake, and fetal programing via epigenetics.

Recherche et / ou projets en cours

2019 – Chercheuse principale « Nutritional Epigenetic Effects in Cattle ». (AAC, services votés, 2019-2023)

2019 – Collaboratrice « Development of functional genomic prediction platform for industry application ». (Chercheurs principaux : C. Li et J. Basarab, Genome Alberta, 2019-2020)

2018 – Collaboratrice «  2018F095R - Genetic and microbial markers for rumen functions and implications in improving cattle feed efficiency ». (Chercheuse principale : L. Guan, Alberta Agriculture and Forestry, 2018-2020)

2018 – Collaboratrice « Genetic analyses of feed intake, feed efficiency, female fertility, and cow lifetime productivity in beef cattle raised under two environments.  » (BCRC, 2018-2023)

Énoncés de recherches/projets

  • La prise alimentaire résiduelle (RFI) et la production de méthane chez les bovins, ainsi que l’amélioration générale de l’efficacité et de la durabilité de la production de viande bovine.
  • Régulation de l’expression des gènes par des moyens alimentaires (nutrigénomique).
  • Potentiels génétiques différents des réponses individuelles aux changements de régime alimentaire (nutrigénétique).
  • Changements permanents de l’expression génique pouvant être programmés dans la génération suivante par la nutrition ou d’autres facteurs influant sur la génération parentale (épigénétique).

En utilisant les modifications de l’expression génique dues à l’alimentation ou à d’autres traitements, on peut mieux comprendre le fonctionnement des systèmes biologiques et appliquer ces connaissances à l’amélioration de la production de viande bovine.

 

  • ration parentale (épigénétique).

Principales publications

  1. Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2020). Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes. Scientific Reports, [online] 10(1), http://dx.doi.org/10.1038/s41598-020-73885-5

    2020 - Consulter les détails de la publication

  2. Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M.V., Wishart, D.S. (2020). Serum metabolite biomarkers for predicting residual feed intake (RFI) of young angus bulls. Metabolites, [online] 10(12), 1-20. http://dx.doi.org/10.3390/metabo10120491

    2020 - Consulter les détails de la publication

  3. Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J., Thundathil, J. (2020). Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets, 60(12), 1491-1502. http://dx.doi.org/10.1071/AN19524

    2020 - Consulter les détails de la publication

  4. Foroutan, A., Fitzsimmons, C., Mandal, R., Piri‐moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L., Wishart, D.S. (2020). The bovine metabolome. Metabolites, [online] 10(6), 1-26. http://dx.doi.org/10.3390/metabo10060233

    2020 - Consulter les détails de la publication

  5. Hadinia, S.H., Carneiro, P.R.O., Fitzsimmons, C.J., Bédécarrats, G.Y., Zuidhof, M.J. (2020). Post-photostimulation energy intake accelerated pubertal development in broiler breeder pullets. Poultry Science, [online] 99(4), 2215-2229. http://dx.doi.org/10.1016/j.psj.2019.11.065

    2020 - Consulter les détails de la publication

  6. Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows: I. Effects on the prepartum performance of the dam and birth weight of the progeny. Journal of Animal Science, [online] 97(7), 3103-3119. http://dx.doi.org/10.1093/jas/skz171

    2019 - Consulter les détails de la publication

  7. Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows. II. Effects on the postpartum performance of the dam and the progeny. Journal of Animal Science, [online] 97(7), 3120-3141. http://dx.doi.org/10.1093/jas/skz172

    2019 - Consulter les détails de la publication

  8. Li, F., Li, C., Chen, Y., Liu, J., Zhang, C., Irving, B., Fitzsimmons, C., Plastow, G., Guan, L.L. (2019). Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle. Microbiome, [online] 7(1), http://dx.doi.org/10.1186/s40168-019-0699-1

    2019 - Consulter les détails de la publication

  9. Añez-Osuna, F., Penner, G.B., Campbell, J., Damiran, D., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., McKinnon, J.J., Lardner, H.A. (2019). Effects of postpartum fat supplementation and source on the reproductive performance of lactating young beef cows grazing cool-season grass pastures. Applied Animal Science, [online] 35(2), 185-198. http://dx.doi.org/10.15232/aas.2018-01791

    2019 - Consulter les détails de la publication

  10. Akanno, E.C., Ekine-Dzivenu, C., Chen, L., Vinsky, M., Abo-Ismail, M.K., Macneil, M.D., Plastow, G., Basarab, J., Li, C., Fitzsimmons, C. (2019). Evaluation of a genomic-enhanced sorting system for feeder cattle. Journal of Animal Science, [online] 97(3), 1066-1075. http://dx.doi.org/10.1093/jas/skz026

    2019 - Consulter les détails de la publication

  11. Hare, K.S., Wood, K.M., Acton, K., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on prepartum BW, ruminal fermentation, nitrogen balance, and skeletal muscle catabolism. Journal of Animal Science, [online] 97(1), 407-423. http://dx.doi.org/10.1093/jas/sky410

    2019 - Consulter les détails de la publication

  12. Johnson, C., Fitzsimmons, C., Colazo, M., Li, C., Kastelic, J., Thundathil, J. (2019). Impacts of residual feed intake and pre-natal diet on reproductive potential of bulls. Animal Production Science, [online] 59(10), 1827-1836. http://dx.doi.org/10.1071/AN18301

    2019 - Consulter les détails de la publication

  13. Hare, K.S., Wood, K.M., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on postpartum ruminal fermentation, blood metabolites, skeletal muscle catabolism, colostrum composition, milk yield and composition, and calf growth performance. Journal of Animal Science, [online] 97(1), 437-455. http://dx.doi.org/10.1093/jas/sky413

    2019 - Consulter les détails de la publication

  14. F Añez-Osuna, G Penner, C Fitzsimmons, M Dugan, J Campbell, P Jefferson, H Lardner, J McKinnon, 351 Effects of level and source of fat in the diet of gestating beef cows on progeny performance., Journal of Animal Science, Volume 96, Issue suppl_3, December 2018, Page 175, https://doi.org/10.1093/jas/sky404.381

    2018 - Consulter les détails de la publication

  15. Mukiibi, R., Vinsky, M., Keogh, K.A., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2018). Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle, 8(1), http://dx.doi.org/10.1038/s41598-018-25605-3

    2018 - Consulter les détails de la publication

  16. Li, X., Yan, Q., Tang, S., Tan, Z., Fitzsimmons, C.J., Yi, K. (2018). Effects of maternal feed intake restriction during pregnancy on the expression of growth regulation, imprinting and epigenetic transcription-related genes in foetal goats, 198 90-98. http://dx.doi.org/10.1016/j.anireprosci.2018.09.005

    2018 - Consulter les détails de la publication

  17. Difford, G.F., Plichta, D.R., Løvendahl, P., Lassen, J., Noel, S.J., Højberg, O., Wright, A.-D.G., Zhu, Z., Kristensen, L., Nielsen, H.B., Guldbrandtsen, B., Sahana, G. (2018). Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows, 14(10), http://dx.doi.org/10.1371/journal.pgen.1007580

    2018 - Consulter les détails de la publication

  18. Ekine-Dzivenu C, Akanno EC, Chen L, McKeown L, Irving B, Baker L, Vinsky M, Miller S, Wang Z, Crowley J, Colazo M, Ambrose D, Juarez M, Bruce H, MacNeil MD, Plastow G, Basarab J, Li C, & Fitzsimmons C. (2018) Improvement of cow feed efficiency using molecular breeding values for residual feed intake - The “Kinsella Breeding Project”. In: Proceedings of the World Congress on Genetics Applied to Livestock Production. vol. Electronic Poster Session - Genetic Gain - Breeding Strategies 2: 809.

    2018 - Consulter les détails de la publication

  19. Paradis, F., Wood, K.M., Swanson, K.C., Miller, S.P., McBride, B.W., Fitzsimmons, C. (2017). Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics, [online] 18(1), http://dx.doi.org/10.1186/s12864-017-4051-5

    2017 - Consulter les détails de la publication

  20. Añez-Osuna, F., Penner, G. B., Fitzsimmons, C. F., Dugan, M. E. R., Campbell, J., Jefferson, P. G., Lardner, H. A. and McKinnon, J. J. 2017. Effects of low vs. high dietary fat and source of fat on the performance of gestating beef cows and subsequent effects on progeny. ASAS-CSAS Joint Annual Meeting (JAM), July 8-12, 2016, Baltimore, MD, USA.

    2017 - Consulter les détails de la publication

Installation de recherche

6000, sentiers C et E
Lacombe, AB T4L 1W1
Canada

Expertise

Language

Anglais

Other languages

Swedish