Dr. Alexandra Long
Je suis une biologiste de recherche dans la laboratoire de toxicologie génétique - une partie de la division des études mechanistes a Santé Canada.
Prix et études
Ph. D., biologie, spécialisation : toxicologie chimique et environnementale. Université d’Ottawa (2017)
Prix du nouveau scientifique de la Genetic Toxicology Association (2017)
Prix de la meilleure affiche du Forum scientifique de Santé Canada (2018)
Prix du meilleur article d’un étudiant dans la revue Environmental and Molecular Mutagenesis (2016)
Prix de la meilleure affiche d’étudiant de la Environmental Mutagenesis and Genomics Society (2015)
Doctorat-Bourse d’études supérieures du Conseil de recherches en sciences naturelles et en génie (2013–2016)
Prix du meilleur article d’un étudiant CANTOX de la Société de toxicologie du Canada (M. Sc.) (2010)
Expérience et / ou de travail international
Représentante canadienne au sein du Groupe d’experts pour l’examen de la proposition d’essai de l’OCDE sur le gène Pig-a (de 2017 à aujourd’hui)
Membre du Genetic Toxicology Technical Committee (GTTC) du Health and Environmental Sciences Institute (HESI) (de 2017 à aujourd’hui)
Membre du conseil de l’Environmental Mutagenesis and Genomics Society (2014-2017)
Coprésidente du Transgenic and In Vivo Mutagenesis Special Interest Group (Environmental Mutagenesis and Genomics Society) (de 2012 à 2016)
Coprésidente du Symposium annuel de l’Institut de biologie d’Ottawa-Carleton (les 29 et 30 avril 2015)
Coprésidente du Student and New Investigator Affairs Committee (Environmental Mutagenesis and Genomics Society) (2013-2015)
Membre du Groupe de travail sur la génomique (Santé Canada)
Lectrice critique des revues Environmental and Molecular Mutagenesis et Toxicology, Mutagenesis, Toxicological Sciences (entre autres)
Professeure invitée au Cours international Alexander Hollænder sur la santé environnementale et la génétique, à Asunción, au Paraguay (du 10 au 13 novembre 2013)
Principales publications
- Long AS, Wills JW, Krolak D, Guo M, Dertinger SD, Arlt VM, White, PA (2018). Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene. Archives of Toxicology 92:967-982.
- Maertens RM, Long AS, White PA (2017). Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading ("False") positive chemicals. Environmental and Molecular Mutagenesis 58(8):582-591.
- Long AS, Lemieux CL, Gagné R, Lambert IB, White PA (2017). Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating Dose-Additivity in a Transgenic Mouse Model. Environmental Science & Technology 51(14):8138-8148
- Valente WJ, Ericson NG, Long AS, White PA, Marchetti F, Bielas JH (2016). Mitochondrial DNA exhibits resistance to induced point and deletion mutations. Nucleic Acids Research. doi: 10.1093/nar/gkw716. [Epub ahead of print]
- Long, AS, Watson, M, Arlt, VM, White, PA (2016). Oral Exposure to Commercially Available Coal Tar-Based Pavement Sealcoat Induces Murine Genetic Damage and Mutations. Environmental and Molecular Mutagenesis 57(7):535-45.
- Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL (2016). Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene. Environmental and Molecular Mutagenesis 57(5):350-63.
- Wills JW*, Long AS*, Johnson GE, Bemis JC, Dertinger SD, Slob W, White PA (2016). *: contributed equally. Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment. Mutagenesis 31(2):265-75.
- Long, AS, Lemieux, CL, Arlt, VM, White, PA (2016). Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay. Toxicology and Applied Pharmacology 290:31-42.
- Chepelev, NL, Long, AS, Williams, A, Kuo, B, Gagné, R, Kennedy, DA, Phillips, DH, Arlt, VM, White, PA, Yauk, CL (2015). Transcriptional profiling of dibenzo(def,p)chrysene-induced spleen atrophy provides mechanistic insights into its immunotoxicity in Muta™Mouse. Toxicological Sciences 149(1):251-68.
- Chepelev, NL, Kennedy, DA, Gagné, R, White, T, Long, AS, Yauk, CL, White, PA (2015). HPLC Measurement of the DNA Oxidation Biomarker, 8-oxo-7,8-dihydro-2'-deoxyguanosine, in Cultured Cells and Animal Tissues. Journal of Visualized Experiments 2015(102), e52697, doi: 10.3791/52697.
- Lemieux, CL, Long, AS, Lambert, IB, Lundstedt, S, Tysklind, M, White, PA (2015). In vitro mammalian mutagenicity of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils. Environmental Science & Technology 49(3): 1787-1796.
- Lemieux, CL, Long, AS, Lambert, IB, Lundstedt, S, Tysklind, M, White, PA (2015). Cancer risk assessment of complex polycyclic aromatic hydrocarbon contaminated soils determined using bioassay-derived levels of benzo(a)pyrene equivalents. Environmental Science & Technology 49(3): 1797-1805.
- Long, AS, Lemieux, CL, Shaikh, N, Yousefi, P, White, PA, Smith, K, Holland, N (2014). Human urinary mutagenicity after wood smoke exposure during traditional temazcal use. Mutagenesis 29(5):367-377.
- Malik, AI, Rowan-Carroll, A, Williams, A, Lemieux, CL, Long, AS, Arlt, VM, Phillips, D.H., White, PA, Yauk, CL. (2013) Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse treated with dibenz[a,h]anthracene. Mutagenesis 28(5):543-554.
- Beyerle, A., Long, AS., White, PA., Kissel, T., Stoeger, T. (2011). Poly(ethylene imine) polymers do not induce mutation nor oxidative DNA damage in vitro in murine FE1 cells. Molecular Pharmaceutics 8(3): 976-981.
- Cohn, CA., Lemieux, CL., Long, AS., Krystol, JK., Vogel, U., White, PA., Madsen, AM. (2011). Physical-chemical and microbiological characterization, and mutagenic activity of airborne PM sampled in a biomass-fueled electrical production facility. Environmental and Molecular Mutagenesis 52(4): 319-330.