Dr Alexander Tsertsvadze

Image Alexander Tsertsvadze
Évaluateur Scientifique

L'examination post-commercialisation de la sécurité des médicaments biologiques et biotechnologiques; évaluation du rapport bénéfice / risque des médicaments; communication des risques; surveiller les effets indésirables des médicaments; mène des activités de réglementation pour les produits de santé commercialisés

Santé Canada

Principales publications

Full Articles

  • Connock M, Armoiry X, Tsertsvadze A, Melendez-Torres GJ, Royle P, Andronis L, Clarke A. Comparative survival benefit of currently licensed second or third line treatments for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) negative advanced or metastatic non-small cell lung cancer: a systematic review and secondary analysis of trials. BMC Cancer 2019;19(1):392. doi: 10.1186/s12885-019-5507-6.
  • Armoiry X, Tsertsvadze A, Connock M, Royle P, Melendez-Torres GJ, Souquet PJ, Clarke A. Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. PLoS One 2018;13(7):e0199575.
  • Armoiry X, Connock M, Tsertsvadze A, Cummins E, Melendez-Torres GJ, Royle P, Clarke A. Ixazomib for relapsed or refractory multiple myeloma: review from an Evidence Review Group on a NICE Single Technology Appraisal. Pharmacoeconomics 2018;36(9):1073-1081.
  • Armoiry X, Tsertsvadze A, Connock M, Melendez-Torres GJ, Clarke A. Systematic Review and Network Meta-Analysis of Treatment Outcomes for Multiple Myeloma. J Clin Oncol 2017; Jul 12:JCO2017731828. doi: 10.1200/JCO.2017.73.1828.
  • Freeman K, Taylor-Phillips S, Connock M, Court R, Tsertsvadze A et al. Test accuracy of drug and antibody assays for predicting response to antitumour necrosis factor treatment in Crohn’s disease: a systematic review and meta-analysis. BMJ Open 2017;7:e014581. doi:10.1136/bmjopen-2016-014581.
  • Auguste P, Tsertsvadze A, Pink J, Court R, McCarthy N, Sutcliffe P, Clarke A. Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis. BMC Infectious Diseases 2017; 17: 200.
  • Freeman K, Tsertsvadze A, Taylor-Phillips S, McCarthy N, Mistry H, Manuel R, et al. Agreement between gastrointestinal panel testing and standard microbiology methods for detecting pathogens in suspected infectious gastroenteritis: Test evaluation and meta-analysis in the absence of a reference standard. PLoS ONE 2017; 12(3): e0173196. doi:10.1371/journal.pone.0173196.
  • Shiri T, Datta S, Madan J, Tsertsvadze A, Royle P, Keeling M, McCarthy N, Petrou S. Indirect impact of childhood pneumococcal conjugate vaccination on invasive pneumococcal disease: a global systematic review and meta-analysis. Lancet Global Health 2017; 5: e51-59.
  • Mozdiak E, Tsertsvadze A, McFarlane M, Widlak M, Tabuso M, Dunlop A, Arasaradnam R. The effect of the 2-week wait referral system on the detection of and mortality from colorectal cancer: protocol of a systematic review and meta-analysis. Systematic Reviews 2016; 5:182.
  • Ahmed S, Khan Z, Si F, Mao A, Pan I, Yazdi F, Tsertsvadze A, Hutnik C, Moher D, et al. Summary of Glaucoma Diagnostic Testing Accuracy: An Evidence-Based Meta-Analysis. J Clin Med Res 2016; 8(9):641-649.
  • Tsertsvadze A, Royle P, Seedat F, Cooper J, Crosby R, McCarthy N. Community-onset sepsis and its public health burden: a systematic review. Systematic Reviews 2016; 5:81.
  • Auguste P, Tsertsvadze A, Court R, Pink J. A systematic review of economic models used to assess the cost-effectiveness of strategies for identifying latent tuberculosis in high-risk groups. Tuberculosis 2016; 99: 81-91.
  • Tsertsvadze A, Chen Y-F, Moher D, Sutcliffe P, McCarthy N. How to conduct systematic reviews more expeditiously? Systematic Reviews 2015; 4:160.
  • Tsertsvadze A, Royle P, McCarthy N. Community-onset sepsis and its public health burden: protocol of a systematic review. Systematic Reviews 2015; 4:119.
  • Taylor-Phillips S, Mistry H, Leslie R, Todkill D, Tsertsvadze A, Connock M, Clarke A. Extending the diabetic retinopathy screening interval beyond 1 year: systematic review. Br J Ophthalmol 2015; doi:10.1136/bjophthalmol-2014-305938.
  • Bassuk EL, Richard MK, Tsertsvadze A. The Prevalence of Mental Illness in Homeless Children: A Systematic Review and Meta-Analysis. Journal of the American Academy of Child & Adolescent Psychiatry 2015; 54 (2): 86-96.
  • Bassuk EL, DeCandia CJ, Tsertsvadze A, Richard MK. The effectiveness of housing interventions and housing and service interventions on ending family homelessness: A systematic review. Am J Orthopsychiatry 2014; 84(5):457-474.
  • Tsertsvadze A, Grove A, Freeman K, Court R, Johnson S, Connock M, Clarke A, Sutcliffe P. Total hip replacement for the treatment of end stage arthritis of the hip: a systematic review and meta-analysis. PLoS One 2014; 9(7):e99804. 
  • Tsertsvadze A, Clar C, Court R, Clarke A, Mistry H, Sutcliffe P. Cost-effectiveness of manual therapy for the management of musculoskeletal conditions: a systematic review and narrative synthesis of evidence from randomized controlled trials. J Manipulative Physiol Ther 2014; 37(6): 343-62. 
  • Clar C, Tsertsvadze A, Court R, Hundt GL, Clarke A, Sutcliffe P. Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskeletal conditions: systematic review and update of UK evidence report. Chiropractic & Manual Therapies 2014; 22:12.
  • Ahmadzai N, Newberry SJ, Maglione MA, Tsertsvadze A, Ansari MT, Hempel S, Motala A, Tsouros S et al. A surveillance system to assess the need for updating systematic reviews. Systematic Reviews 2013; 2:104.
  • Hartling L, Milne A, Hamm MP, Vandermeer B, Ansari M, Tsertsvadze A, Dryden D. Testing the Newcastle Ottawa Scale showed low reliability between individual reviewers. J Clin Epidemiol 2013; 66(9): 982-93.
  • Hartling L, Hamm MP, Milne A, Vandermeer B, Santaguida PL, Ansari M, Tsertsvadze A, Hempel S, Shekelle P, Dryden DM. Testing the Risk of Bias tool showed low reliability between individual reviewers and across consensus assessments of reviewer pairs. J Clin Epidemiol 2013; 66(9): 973-81.
  • Kanji S, Seely D, Yazdi F, Tetzlaff J, Singh K, Tsertsvadze A, et al. Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review. BMC Systematic Reviews 2012; 1:26.
  • Foxcroft DR and Tsertsvadze A. Universal alcohol misuse prevention programmes for children and adolescents: Cochrane systematic reviews. Perspectives in Public Health 2012; 132: 128.
  • Foxcroft DR, Tsertsvadze A. Universal school-based prevention programs for alcohol misuse in young people (Review). Evid.-Based Child Health 2012; 7(2): 450–575. 
  • Fernandez-Hermida JR, Calafat A, Becoña E, Tsertsvadze A, Foxcroft DR. Assessment of Generalizability, Applicability, and Predictability (GAP) for evaluating external validity in studies of universal family-based prevention of alcohol misuse in young people: systematic methodological review of randomized controlled trials. Addiction 2012; 107: 1570-1579.
  • Gaudet LM, Singh K, Weeks L, Skidmore B, Tsertsvadze A, Ansari MT. Effectiveness of terbutaline pump for the prevention of preterm birth. A Systematic review and meta-analysis. PLoS ONE 2012; 7(2): e31679. doi:10.1371/journal.pone.0031679
  • Furlan A, Yazdi F, Tsertsvadze A, Gross A, Van Tulder M, Santaguida L, Gagnier J, Ammendolia C, Dryden T, Doucette S, Skidmore B, Daniel R, Ostermann T, Tsouros S. A systematic review and meta-analysis of efficacy, cost-effectiveness, and safety of selected Complementary and Alternative Medicine for neck and low-back pain. Evidence-Based Complementary and Alternative Medicine 2011, volume 2012, Article ID 953139, 61 pages, doi:10.1155/2012/953139
  • Dumais V, Nault P, Tsertsvadze A, Forbes TL. Conduit vessel blood flow during the trek to Mount Everest base camp. Wilderness Environ Med 2011; 22(4): 309-315.
  • Foxcroft DR, Tsertsvadze A. Universal multi-component prevention programs for alcohol misuse in young people. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD009307. DOI: 10.1002/14651858.CD009307.
  • Foxcroft DR, Tsertsvadze A. Universal family-based prevention programs for alcohol misuse in young people. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD009308. DOI: 10.1002/14651858.CD009308.
  • Turner L, Singh K, Garritty C, Tsertsvadze A, Manheimer E, Wieland S, Galipeau J, Moher D. An evaluation of the completeness of safety reporting in reports of complementary and alternative medicine trials.  BMC Complementary and Alternative Medicine 2011; 11 (1): 67
  • Tsertsvadze A, Maglione M, Chou R, Garritty C, Coleman C, Lux L, Bass E, Balshem H, Moher D. Current efforts for updating comparative effectiveness reviews: Agency for Healthcare Research and Quality (AHRQ) and the Effective Health-Care Program. J Clin Epidemiol 2011; 64(11): 1208-1215
  • Foxcroft DR, Tsertsvadze A. Universal school-based prevention programs for alcohol misuse in young people. Cochrane Database of Systematic Reviews 2011, Issue 5. Art. No.: CD009113. DOI: 10.1002/14651858.CD009113
  • Garritty C, Tsertsvadze A, Tricco AC, Sampson M, Moher D. Updating Systematic Reviews: An International Survey. PLoS ONE 2010; 5(4): e9914. doi: 10.1371/journal.pone.0009914
  • Tsertsvadze A, Fink HA, Yazdi F, MacDonald R, Bella AJ, Ansari MT, Garritty C, Soares-Weiser K, Daniel R, Sampson M, Fox S, Moher D, Wilt TJ. Oral Phosphodiesterase Type 5 Inhibitors and Hormonal Treatments for Erectile Dysfunction: A Systematic Review and Meta-analysis. Ann Intern Med 2009; 151: 650-661
  • Tsertsvadze A. Rates of Non-Arteritic Ischemic Optic Neuropathy in Male Veterans Prescribed Phosphodiesterase-5 inhibitors. Am J Ophthalmol 2009; 148(4): 625
  • Ansari MT, Tsertsvadze A, Moher D. Grading Quality of Evidence and Strength of Recommendations: A Perspective. PLoS Med 2009; 6 (9): e1000151.doi: 10.1371/journal.pmed. 1000151
  • Sharma M, Ansari MT, Abou-Setta AM, Soares-Weiser K, Ooi TC, Sears M, Yazdi F, Tsertsvadze A, Moher D. Systematic Review: Comparative Effectiveness and Harms of Combinations of Lipid-Modifying Agents and High-Dose Statin Monotherapy. Ann Intern Med 2009; 151: 622-630
  • Tsertsvadze A, Yazdi F, Fink HA, MacDonald R, Wilt TJ, Bella AJ, Ansari MT, Garritty C, Soares-Weiser K, Daniel R, Sampson M, Moher D. Oral Sildenafil Citrate (Viagra) for Erectile Dysfunction: A Systematic Review and Meta-Analysis of Harms. Urology 2009; 74 (4): 831-836
  • O’Donnell S, Cranney A, Horsley T, Weiler HA, Atkinson SA, Hanley DA, Ooi DS, Ward L, Barrowman N, Fang M, Sampson M, Tsertsvadze A, and Yazdi F. Efficacy of food fortification on serum 25-hydroxyvitamin D concentrations: systematic review. Am J Clin Nutr 2008; 88: 1528-1534
  • Moher D, Tsertsvadze A, Tricco AC, Eccles M, Grimshaw J, Sampson M, Barrowman N. When and How To Update Systematic Reviews. The Cochrane Database of Systematic Reviews 2008; Issue 1
  • Moher D, Tsertsvadze A, Tricco AC, Eccles M, Grimshaw J, Sampson M, Barrowman N. A Systematic Review Identified Few Methods and Strategies Describing When and How to Update Systematic Reviews. J Clin Epidemiol 2007; 60: 1095-1104
  • Rostom A, Dube C, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, and Moher D. Nonsteroidal Anti-Inflammatory Drugs and Cyclooxygenase-2 Inhibitors for Primary Prevention of Colorectal Cancer: A Systematic Review Prepared for the US Preventive Services Task Force. Ann Intern Med 2007; 146: 376-389
  • Dube C, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, and Moher D. The Use of Aspirin for Primary Prevention of Colorectal Cancer: A Systematic Review Prepared for the US Preventive Services Task Force. Ann Intern Med 2007; 146: 365-375
  • Moher D, Horsley T, Morgan K, Tricco A, Tsertsvadze A. Blinded Versus Unblinded Assessments of Risk-of-Bias in Studies Included in a Systematic Review (Protocol). The Cochrane Database of Methodology Reviews 2007; Issue 4
  • Moher D, Tsertsvadze A. Systematic Reviews: When is an Update an Update? Lancet 2006; 367: 881-883

Evidence Reports/Technology Assessment

  • Auguste P, Tsertsvadze A, Pink J, Court R, Seedat F, et al. Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation. Health Technol Assess 2016; 20(38).
  • Freeman K, Mistry H, Tsertsvadze A, Royle P, McCarthy N, Taylor-Phillips S, et al. Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis. Health Technol Assess 2017; 21 (23).
  • Tsertsvadze A, Gurung T, Court R, Clarke A, Sutcliffe P. Clinical effectiveness and cost-effectiveness of elemental nutrition for the maintenance of remission in Crohn’s disease: a systematic review and meta-analysis. Health Technol Assess 2015; 19 (26).
  • Clarke A, Pulikottil-Jacob R, Grove A, Freeman K, Mistry H, Tsertsvadze A, Connock M, Court R, et al. Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation. Health Technol Assess 2015;19(10): 1-668.
  • Newberry SJ, Ahmadzai N, Motala A, Tsertsvadze A, Maglione M, Ansari MT, Hempel S, Tsouros S, Schneider Chafen J, Shanman R, Skidmore B, Moher D, Shekelle, PG. Surveillance and Identification of Signals for Updating Systematic Review: Implementation and Early Experience. Methods Research Report. AHRQ Publication No.13-EHC088-EF. Rockville, MD: Agency for Healthcare Research and Quality; June 2013.www.effectivehealthcare.ahrq.gov/reports/final.cfm.
  • Seely D, Kanji S, Yazdi F, Tetzlaff J, Singh K, Tsertsvadze A, Sears ME, Tricco A, Ooi TC, Turek M, Tsouros S, Skidmore B, Daniel R, Ansari MT. Dietary Supplements in Adults Taking Cardiovascular Drugs. Comparative Effectiveness Review No. 51. (Prepared by the University of Ottawa Evidence-based Practice Center under Contract No. HHSA 290-2007-10059-I.) AHRQ Publication No. 12-EHC021-EF. Rockville, MD: Agency for Healthcare Research and Quality. April 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm.
  • Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco A, Tsouros S, Skidmore B, Daniel R, Moher D. Diagnosis and Management of Febrile Infants (0–3 months). Evidence Report/Technology Assessment No. 205 (Prepared by the University of Ottawa Evidence-based Practice Center under Contract No. HHSA 290-2007-10059-I.) AHRQ Publication No. 12-E004-EF. Rockville, MD: Agency for Healthcare Research and Quality. March 2012.http://www.ahrq.gov/clinic/epcix.htm.
  • Hartling L, Hamm M, Milne A, Vandermeer B, Santaguida PL, Ansari M, Tsertsvadze A, Hempel S, Shekelle P, Dryden DM. Validity and inter-rater reliability testing of quality assessment instruments. (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021-I.) AHRQ Publication No. 12-EHC039-EF. Rockville, MD: Agency for Healthcare Research and Quality. March 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm.
  • Viswanathan M, Ansari MT, Berkman ND, Chang S, Hartling L, McPheeters LM, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze A, Treadwell JR. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions. Agency for Healthcare Research and Quality Methods Guide for Comparative Effectiveness Reviews. March 2012. AHRQ Publication No. 12-EHC047-EF. Available at: www.effectivehealthcare.ahrq.gov/
  • Gaudet L, Singh K, Weeks L, Skidmore B, Tsouros S, Tsertsvadze A, Daniel R, Doucette S, Walker M, Ansari MT. Terbutaline Pump for the Prevention of Preterm Birth. Comparative Effectiveness Review No. 35. AHRQ Publication No. 11-EHC068-EF. Rockville, MD: Agency for Healthcare Research and Quality. September 2011. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm.
  • Tsertsvadze A, Maglione M, Chou, R, Garritty C, Coleman C, Lux L, Bass E, Balshem H, Moher D. Updating Comparative Effectiveness Reviews: Current Efforts in AHRQ’s Effective Health Care Program. Methods Guide for Comparative Effectiveness Reviews. AHRQ Publication No. 11-EHC057-EF. Rockville, MD: Agency for Healthcare Research and Quality. July 2011. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm.
  • Booth RA, Ansari MT, Tricco AC, Loit E, Weeks L, Doucette S, Skidmore B, Hoch JS, Tsouros S, Sears M, Sy R, Karsh J, Mani S, Galipeau J, Yurkiewich A, Daniel R, Tsertsvadze A, Yazdi F. Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs. Evidence Report/Technology Assessment 2010; No. 196. Rockville, MD: Agency for Healthcare Research and Quality. www.ahrq.gov/downloads/pub/evidence/pdf/tpmt/tpmt.pdf
  • Furlan A, Yazdi F, Tsertsvadze A, Gross A, Van Tulder, M, Santaguida L, Cherkin D, Gagnier J, Ammendolia C, Ansari M, Ostermann T, Dryden T, Doucette S, Skidmore B, Daniel R, Tsouros S, Weeks L, Galipeau J. Complementary and Alternative Therapies for Back Pain II. Evidence Report/Technology Assessment 2010; No. 194. Rockville, MD: Agency for Healthcare Research and Quality. www.ahrq.gov/clinic/tp/backcam2tp.htm
  • Sharma M, Ansari M, Soares-Weiser K, Abou-setta AM, Ooi TC, Sears M, Yazdi F, Tsertsvadze A, Moher D. Comparative Effectiveness of Lipid-Modifying Agents. Comparative Effectiveness Review 2009; No. 16. Rockville, MD: Agency for Healthcare Research and Quality. www.effectivehealthcare.ahrq.gov/reports/final.cfm
  • Tsertsvadze A, Yazdi F, Fink HA, MacDonald R, Wilt TJ, Soares-Weiser K et al. Diagnosis and Treatment of Erectile Dysfunction. Evidence Report/Technology Assessment 2009; No. 171. Rockville, MD: Agency for Healthcare Research and Quality.
  • Cranney A, Horsley T, O’Donnell S, Weiler HA, Puil L, Ooi DS, Atkinson SA, Ward LM, Moher D, Hanley DA, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Effectiveness and Safety of Vitamin D in Relation to Bone Health. AHRQ Evidence Report/Technology Assessment 2007; No. 158
  • Rostom A, Dube C, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, and Moher D. Use of Aspirin and NSAIDs to Prevent Colorectal Cancer. AHRQ Evidence Synthesis Report 2007; No. 45
  • Dubé C, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D. The Use of Aspirin for Primary Prevention of Colorectal Cancer: Systematic Review for the U.S. Preventive Services Task Force. Ann Intern Med 2007; 146: 365-375. AHRQ March 2007. http://www.ahrq.gov/clinic/uspstf07/aspcolo/aspcolorev.htm
  • Moher D, Tsertsvadze A, Tricco A, Eccles M, Grimshaw J, Sampson M, Barrowman N. When and How to Update Systematic Reviews: A Methodological Systematic Review. The report submitted to CADTH, April 2006
  • Lewin G, Schachter HM, Yuen D, Merchant P, Mamaladze V, Tsertsvadze A, et al. Effects of Omega-3 Fatty Acids on Child and Maternal Health. AHRQ Evidence Report/Technology Assessment 2005; No. 118

Books/book chapters

  • Randomized Clinical Trials of Nonpharmacological Treatments (edited by Boutron I, Ravaud P, Moher D) - Chapman and Hall/CRC Biostatistics Series, Taylor & Francis Group 2012; Chapter Name: Methodological and Reporting Considerations for Systematic Reviews of Nonpharmacological Interventions
  • IOM (Institute of Medicine). 2011. Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: The National Academies Press. [contributed as a consultant]