Aiming Wang, Ph.D.

Image Aiming Wang
Chercheur scientifique

Dans mon programme de recherche, j’étudie les agents pathogènes viraux qui menacent les cultures agricoles au Canada. De nombreux travaux de recherche ont été menés pour identifier les agents pathogènes viraux qui causent des maladies dévastatrices chez le soja, les céréales, les grandes cultures horticoles et les légumes de serre, et pour mieux comprendre le processus infectieux des principaux virus identifiés. La pluparts des travaux de recherche portent sur le développement d’une résistance génétique, de vaccins et d’autres technologies nouvelles pour lutter contre ces virus.

Agriculture et Agroalimentaire Canada

Recherche et / ou projets en cours

  • Développement de la résistance génétique au virus de la sharka dans Prunus
  • Développement de la résistance génétique au virus de la mosaïque du soja au moyen d’une technologie de modification génétique
  • Caractérisation moléculaire des agents pathogènes viraux attaquant les cultures horticoles comme les légumes de serre, les fraises, les cerisiers et les pommiers, et élaboration de stratégies de lutte dirigées contre ces agents pathogènes viraux
  • Meilleure compréhension du processus infectieux des virus et interaction moléculaire virus‑plante pour le développement de technologies antivirales nouvelles.

Énoncés de recherches/projets

  • Identification de nouveaux facteurs de l’hôte nécessaires à l’infection virale
  • Identification de nouveaux rôles fonctionnels des protéines virales
  • Découvertes dans la course coévolutionnaire entre les virus et les hôtes végétaux
  • Identification des nouveaux virus infectant les légumes de serre et les grandes cultures au Canada

Activités professionnelles / intérêts

  • Compréhension des éléments d'interaction moléculaire virus-plante et des mécanismes d'expression et de réplication en génomique virale
  • Isolement moléculaire des facteurs de l'hôte et des gènes de résistance naturelle
  • Élaboration de nouvelles stratégies antivirales par la biotechnologie et avantages du recours aux virus des plantes
  • Formation des étudiants au doctorat et des chercheurs postdoctoraux 

Prix et études

Ph.D., Université de la Colombie-Britannique en 1999

Récolte d'or (innovation et excellence), Agriculture et Agroalimentaire Canada en 2010

Médaille du jubilé de diamant de la reine Elizabeth II, gouvernement du Canada, en 2013

Prix ​​de recherche exceptionnelle de la Société canadienne de phytopathologie en 2019

Ruth Allen Award, de la Société américaine de phytopathologie en 2019

Expérience et / ou de travail international

Recherche concertée avec des collègues en Chine, aux États-Unis et en France

Principales publications

Pour une list complète de publications: Aiming Wang sur AAC en-ligne

  • Li F, Wang A* (2019) RNA-Targeted Antiviral Immunity: More Than Just RNA Silencing. Trends in Microbiology https://doi.org/10.1016/j.tim.2019.05.007

  • Cui H, Wang A* (2019) The biological impact of the hypervariable N-terminal region of potyviral genomes. Annual Review of Virology https://www.annualreviews.org/doi/abs/10.1146/annurev-virology-092818-015843

  • Bujarski JJ, Gallitelli D*, García-Arenal F, Pallás VB, Palukaitis P, Reddy MK, Wang A, ICTV Report Consortium. (2019) ICTV Virus Taxonomy Profile: Bromoviridae. Journal of General Virology https://doi.org/10.1099/jgv.0.001282

  • Tran HH, Chen C, Chen H, Menassa R, Hao H, Bernards M, Hüner NPA, Wang A* (2019) Development of a cucumber green mottle mosaic virus-based expression vector for the production in cucumber of neutralizing epitopes against devastating animal virus. Journal of Virological Methods 269: 18-25. https://doi.org/10.1016/j.jviromet.2019.04.006

  • Zhang F, Yang Z, Hong N, Wang G, Wang A and Wang L* (2019) Identification and characterization of water chestnut Soymovirus-1 (WCSV-1), a novel Soymovirus in water chestnuts (Eleocharis dulcis). BMC Plant Biology 19: 159. https://doi.org/10.1186/s12870-019-1761-7

  • Wu X, Liu J, Chai M, Wang J, Li D, Wang A, Cheng X* (2019) The potato virus X TGBp2 protein plays dual functional roles in viral replication and movement. Journal of Virology 93 (5): e01635-18. https://jvi.asm.org/content/93/5/e01635-18.full

  • Yang K, Shen W, Li Y, Li Z, Miao W, Wang A, Cui H* (2019) Areca palm necrotic ringspot virus, classified within a recently proposed genus Arepavirus of the family Potyviridae, is classified with necrotic ringspot virus disease in areca palm. Phytopathology 109: 887-894.  https://doi.org/10.1094/PHYTO-06-18-0200-R
  • Li F, Zhang C, Li Y, Wu G, Hou X, Zhou X, Wang A* (2018) Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Nature Communications 9: 1268. https://www.nature.com/articles/s41467-018-03658-2 DOI: 10.1038/s41467-018-03658-2
  • Li F, Wang A* (2018) RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLoS Pathogens 14(8): e1007228. https://doi.org/10.1371/journal.ppat.1007228
  • Wu G, Cui X, Chen H, Renaud JB, Yu K, Chen X*, Wang A* (2018) Dynamin-like proteins of endocytosis in plants are co-opted by potyviruses to enhance virus infection. Journal of Virology 92 (23): e01320-18 https://jvi.asm.org/content/early/2018/09/20/JVI.01320-18 DOI: 10.1128/JVI.01320-18 (Spotlight paper)
  • Wang A* (2018) Virus and Host Plant Interactions. In: eLS. John Wiley & Sons Ltd, Chichester. https://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0000758.pub3
  • Wang LH, Luo H, Hu W, Yang Y, Hong N, Wang G, Wang A, Wang L* (2018) De novo transcriptomic assembly and mRNA expression patterns of Botryosphaeria dothidea infection with mycovirus chrysovirus 1 (BdCV1) and partitivirus 1 (BdPV1). Virology Journal 15: 216. https://doi.org/10.1186/s12985-018-1033-4
  • Cheng X, Xiong R, Li Y, Li F, Zhou X, Wang A* (2017) Sumoylation of the Turnip mosaic virus RNA polymerase promotes viral infection by counteracting the host NPR1-mediated immune response. Plant Cell 29(3): 508-525. DOI: http:/​/​dx.​doi.​org/​10.​1105/​tpc.​16.​00774
  • Park SH, Li F, Renaud J, Shen W, Li Y, Guo L, Cui H, Sumarah M, Wang A* (2017) NbEXPA1, an α-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection. Plant Journal 92: 846-861. DOI: 10.1111/tpj.13723. http://onlinelibrary.wiley.com/doi/10.1111/tpj.13723/full.
  • Cui H, Wang A* (2017) An efficient viral vector for functional genomic studies of Prunus fruit trees and its induced resistance to Plum pox virus via silencing of a host factor gene. Plant Biotechnology Journal 15(3): 344-356. DOI: 10.1111/pbi.12629. http://onlinelibrary.wiley.com/doi/10.1111/pbi.12629/full.
  • Cheng X, Wang A* (2017) The potyviral silencing suppressor protein VPg mediates degradation of SGS3 via ubiquitination and autophagy pathways. Journal of Virology 91(1): e01478-16. https://doi.org/10.1128/JVI.01478-16.
  • Chen H, Arsovski AA, Yu K, Wang A* (2017) Deep sequencing leads to the identification of eukaryotic translation initiation factor 5a as a key element in Rsv1-mediated lethal systemic hypersensitive response to Soybean mosaic virus infection in soybean. Molecular Plant Pathology 18(3): 391-404. DOI: 10.1111/mpp.12407.
  • Cui X, Yaghmaiean H, Wu G, Wu X, Chen X, Thorn G, Wang A* (2017) The C-terminal region of the Turnip mosaic virus P3 protein is essential for viral infection via targeting P3 to the viral replication complex. Virology 510: 147-455.
  • Park SH, Elhiti M, Wang H, Xu A, Brown A, Wang A* (2017). Adventitious root formation of in vitro peach shoots is regulated by auxin and ethylene. Scientia Horticulturae 226: 250–260.
  • Ding X, Chen D, Wang A, Zhang J, Wu Z (2017) First Report of Strawberry pallidosis-associated virus on strawberry in China. Plant Disease 100 (6): 1254.
  • Li F, Zhao N, Li Z, Xu X, Wang Y, Yang X, Liu SS, Wang A, Zhou X* (2017) A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana. PLoS Pathogens 13(2): e1006213.
  • Wylie SJ*, Adams M, Chalam C, Kreuze J, López-Moya JJ, Ohshima K, Praveen S, Rabenstein F, Stenger D, Wang A, Zerbini FM (2017) ICTV Virus Taxonomy Profile: Potyviridae. Journal of General Virology 98: 352-354. DOI: 10.1099/jgv.0.000740
  • Cheng X, Wang A* (2017) Multifaceted defense and counter-defense in co-evolutionary arms race between plants and viruses. Communicative & Integrative Biology 10(4): e1341025.
  • Cui H, Wang A.* 2016. The Plum pox virus 6K1 protein is required for viral replication and targets the viral replication complex at the early infection stage. Journal of Virology 90: 5119-5131.
  • Arias Gaguancela OP, Zúñiga LP, Arias AV, Halterman D, Flores FJ, Johansen IE, Wang A, Yamaji Y, Verchot-Lubicz J* 2016. The IRE1/bZIP60 pathway and Bax inhibitor 1 suppress systemic accumulation of potyviruses and potexviruses in Arabidopsis and N. benthamiana plants. Molecular Plant Microbe Interaction DOI: 10.1094/MPMI-07-16-0147-R
  • Li Y, Cui H, Cui X, Wang A* 2016. The altered photosynthetic machinery during compatible virus infection. Current Opinion in Virology 17: 19-24.
  • Li Y, Xiong R, Bernards MA, Wang A* 2016. Recruitment of Arabidopsis RNA helicase AtRH9 to the viral replication complex by viral replicase to promote Turnip mosaic virus replication. Scientific Reports 6: 30297. doi: 10.1038/srep30297
  • Zhang L, Zhang C, Wang A* 2016. Divergence and conservation of the major UPR branch IRE1-bZIP signaling pathway across eukaryotes. Scientific Reports 6: 27362. doi: 10.1038/srep27362
  • Chen H, Arsovski AA, Yu K, Wang A* 2016. Genome-wide investigation using sRNA-seq, degradome-seq and transcriptome-seq reveals regulatory networks of microRNAs and their target genes in soybean during Soybean mosaic virus infection. PLoS ONE 11(3): e0150582
  • Bhagwat B, Dickison V, Ding X, Walker MC, Bernardy MG, Bouthillier MJ, Creelman A, DeYoung RM, Li Y, Nie X*, Wang A*, Xiang Y*, Sanfaçon H* 2016. Genome sequence analysis of five Canadian isolates of Strawberry mottle virus reveals extensive intra-species diversity and a longer RNA2 with increased coding capacity compared to a previously characterized European isolate. Archives of Virology 161: 1657-1663.
  • Ding X, Li Y, Hernández-Sebastià C, Abbasi PA, Fisher P, Celletti M, Wang A* 2016. First Report of Strawberry crinivirus 4 on strawberry in Canada. Plant Disease 100: 1254.
  • Elhiti M, Wang HY, Austin RS, Chen B, Brown DCW, Wang A* 2016. Generation of chemically induced mutations using in vitro propagated shoot tip tissues for genetic improvement of fruit trees. Plant Cell, Tissue and Organ Culture: Journal of Plant Biotechnology 124(2): 447-452. doi : 10.1007/s11240-015-0894-0
  • Liu J, Zhang X, Yang Y, Hong N, Wang G, Wang A, Wang L* 2016. Characterization of virus-derived small interfering RNAs in Apple stem grooving virus-infected in vitro-cultured Pyrus pyrifolia shoot tips in response to high temperature treatment. Virology Journal 13: 166. DOI: 10.1186/s12985-016-0625-0.
  • Wang, A* 2015. Dissecting the molecular network of virus-plant interactions: the complex roles of host factors. Annual Review of Phytopathology 53: 45-66.
  • Zhang, L., Chen, C., Brandizzi, F., Verchot, J., Wang, A* 2015. The UPR branch IRE1-bZIP60 in plants is complementary to the only UPR pathway in yeast and essential for viral infection. PLoS Genetics 11(4): e1005164. doi:10.1371/journal.pgen.1005164
  • Cheng, X., Deng, P., Cui, H., Wang, A* 2015. Visualizing double-stranded RNA distribution and dynamics in living cells by dsRNA binding-dependent fluorescence complementation. Virology 485: 439-451.
  • Chen, H., Zhang, L., Yu, K., Wang, A* 2015. Pathogenesis of Soybean mosaic virus in soybean carrying Rsv1 gene is associated with miRNA and siRNA pathways, and breakdown of AGO1 homeostasis. Virology 476: 395-404.
  • Deng, P., Wu, Z., Wang, A* 2015. The multifunctional protein CI of potyviruses plays interlinked and distinct roles in viral genome replication and intercellular movement. Virology Journal 12: 141. doi:10.1186/s12985-015-0369-2.
  • Liu J, Zhang X, Zhang F, Hong N, Wang G, Wang A, Wang L* 2015. Identification and characterization of microRNAs from in vitro-grown pear shoots infected with Apple stem grooving virus in response to high temperature using small RNA sequencing. BMC Genomics 16: 945. doi : 10.1186/s12864-015-2126-8
  • Ma, X., Cui, H., Bernardy, M.G., Tian, L.-N., Abbasi, P.A., Wang, A* 2015. Molecular characterization of a Strawberry mild yellow edge virus isolate from Canada. Canadian J Plant Pathology 37: 369-375.
  • Chen, B., Bernards, M., Wang, A* 2015. Complete genome sequence of a bell pepper endornavirus isolate from Canada. Genome Announcements 3(4): e00905-15.
  • Zhang, L., Khabbaz, S.E., Wang, A., Li, H., Abbasi, P.A.* 2015. Detection and characterization of broad-spectrum anti-pathogen activity of novel rhizobacterial isolates and suppression of Fusarium crown and root rot disease of tomato. Journal of Applied Microbiology 118(3): 685-703.
  • Khabbaz, S.E., Zhang, L., Cáceres, L.A., Sumarah, M., Wang, A., and Abbasi, P.A.* 2015. Characterization of antagonistic Bacillus and Pseudomonas strains for biocontrol potential and suppression of damping-off and root rot diseases. Annals of Applied Biology 166(3): 456-471.
  • Wang, A*, Tian, L., Brown, D.C.W., Svircev, A.M., Stobbs, L.W., and Sanfaçon, H. 2015. Generation of efficient resistance to Plum pox virus (PPV) in Nicotiana benthamiana and Prunus domestica expressing triple intron-spanned double-hairpin RNAs. Acta Hort. (ISHS) 1063: 77-84.
  • Chen, G.H., Yan, W., Yan, W., Yang, S.P., Wang, A., Gai, J.Y., and Zhu, Y.L.* 2015. Overexpression of Rice Phosphate Transporter Gene OsPT2 Enhances Tolerance to Low Phosphorus Stress in Soybean. Journal of Agricultural Science and Technology B 17(2): 469-482.

Affiliations

  • Professeur auxiliaire, Department of Biology, University of Western Ontario
  • Rédacteur en chef, MPMI
  • Rédacteur adjoint, PLoS Pathogenes
  • Membre du Comité de lecture du Journal of Vriology, MPP et Virology
  • Membre à vie, American Society for Virology
  • Membre de plein droit, International Society for Molecular Plant-Microbe Interactions

Langue

Anglais