Bhaja K. Padhi, PhD,DABT
Recherche et / ou projets en cours
Détermination des dangers neurotoxiques posés par les substances chimiques provenant de l'environnement au moyen d'approches moléculaire et génomique.
Énoncés de recherches/projets
- Incidence des substances toxiques sur les processus de développement du cerveau tels que la myélinisation.
- Établissement d'une méthodologie visant à mesurer le niveau de transcription du gène à la suite de l'exposition à une substance toxique.
- Développement de marqueurs biologiques pour l'évaluation du risque neurotoxique.
Activités professionnelles / intérêts
Réviseur de manuscrits – Journal of Environmental Health
Prix et études
Boursier postdoctoral (Institut de recherche de l'Hôpital d'Ottawa, Université d'Ottawa).
Principales publications
Padhi, B.K. Singh, M., Rosales, M., Pelletier, G and Cakmak, S. 2018. A PCR-based quantitative assay for the evaluation of mRNA integrity in rat. Biomolecular Detection and Quantification. 15:18-23.
Padhi, B. K., Singh, M., Huang, N., and Pelletier, G. 2016. A PCR-based approach to assess genomic DNA contamination in RNA: Application to rat RNA samples. Analytical Biochemistry, 494:49-51.
Padhi, B. K., Rosales, M., and Pelletier, G. 2015. Perinatal exposure to methyl mercury down- regulated Plp1 and Cnp splice variants in juvenile rat cerebellum. Neurotoxicology,48:223-230.
Padhi, B.K., Zigler, Jr. J.S., Padhi, P., Hose, S., and Sinha, D. 2014. Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene. Genesis, 52:378-386.
Padhi, B.K., and Pelletier, G. 2012. Perturbation of Myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury. Toxicology Letters, 213:374-380.
Zhang, J., Wagh P., Guay, D., Sanchez-Pulido, L., Padhi, B.K., Korzh, V., Andrade-Navarro, M. A., and Akimenko, M-A. 2010. Loss of fish actinotrichia proteins and the fin-to-limb transition. Nature, 466:234-238.
Padhi, B.K., Pelletier, G., Williams, A., Berndt, L., Yauk, C., Bower, W.J., and Chu, I. 2008. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicology Letters, 176:93-103.
Padhi, B.K., Akimenko, M-A., and Ekker, M. 2006. Independent expansion of the keratin gene family in teleostean fish and mammals: An insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene, 368:37-45.
Padhi, B.K., Jolly, L., Tellis, P., Smith, A., Nanjappa, P., Chevrette, M., Ekker, M., and Akimenko, M-A. 2004. A screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Developmental Dynamics, 231:527-541.
Installation de recherche
Expertise
Affiliations
Chercheur invité, Wilmer Eye Institute, Johns Hopkins University, Baltimore, É.-U.