Aiming Wang, Ph. D.

Image Aiming Wang
Chercheur scientifique

Dans mon programme de recherche, j’étudie les agents pathogènes viraux qui menacent les cultures agricoles au Canada. De nombreux travaux de recherche ont été menés pour identifier les agents pathogènes viraux qui causent des maladies dévastatrices chez le soja, les céréales, les grandes cultures horticoles et les légumes de serre, et pour mieux comprendre le processus infectieux des principaux virus identifiés. La pluparts des travaux de recherche portent sur le développement d’une résistance génétique, de vaccins et d’autres technologies nouvelles pour lutter contre ces virus.

Recherche et / ou projets en cours

  • Développement de matériels génétiques de pêche résistants au virus de la variole du prunier (PPV) 
  • Caractérisation des maladies émergentes du déclin des pommiers et des cerisiers au Canada
  • Environnement durable et contrôlé Systèmes de production agricole
  • Développement d’une résistance génétique au virus du fruit brun rugose de la tomate
  • Développement de nouvelles stratégies contre le virus du fruit brun de la tomate (APMS)
  • Interactions moléculaires plantes-virus : défense et contre-défense (CRSNG, via l’Université Western)

Énoncés de recherches/projets

Publications les plus récentes :

Articles de revues 

  1. Zhang S, Griffiths G, Marchand G, Bernards M, Wang A* (2022) Tomato brown rugose fruit virus: an emerging and rapidly spreading plant RNA virus that threatens tomato production worldwide. Molecular Plant Pathology published online  https://doi.org/10.1111/mpp.13229
  2. Xiong R, Wang A, Marsolais F, Todd C* (2022). A fast and efficient method to introduce Apple Latent Spherical Virus to legume plants via Agrobacterium rhizogenes-mediated transformation of hairy roots. Legume Science  published online http://doi.org/10.1002/leg3.154
  3. Wu G, Jia Z, Rui P, Zheng H, Lu Y, Lin L, Peng J, Rao S, Wang A, Chen J*, Yan F* (2022) Acidic dileucine motifs in the cylindrical inclusion protein of turnip mosaic virus are crucial for endosomal targeting and viral replication. Molecular Plant Pathology published online https://doi.org/10.1111/mpp.13231
  4. Usovsky M, Chen P*, Li D, Wang A, Shi A, Zheng C, Shakiba E, Lee D, Canella Vieira C, Lee YC, Wu C, Cervantez I, Dong D (2022) Decades of genetic research on Soybean mosaic virus resistance in soybean. Viruses 14(6): 1122. https://doi.org/10.3390/v14061122
  5. Jia D, Liang Q, Liu H, Li G, Zhang X, Chen Q, Wang A, Wei T* (2022) A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors. PLoS Pathogens 18: e1010506. https://doi.org/10.1371/journal.ppat.1010506
  6. Wu G, Jia Z, Ding K, Zheng H, Lu Y, Lin L, Peng J, Rao S, Wang A, Chen J*, Yan F* (2022) Turnip mosaic virus co-opts the vacuolar sorting receptor VSR4 to promote viral genome replication in plants by targeting viral replication vesicles to the endosome. PLoS Pathogens 18(1): e1010257. https://doi.org/10.1371/journal.ppat.1010257
  7. Zhang M, Gong P, Ge L, Li Y, Chang Z, Qiao R, Zhou X, Wang A*, Li F* (2022) Nuclear Exportin 1 (XPO1) binds to the nuclear localization/export signal of the turnip mosaic virus NIb to promote viral infection. Frontiers in Microbiology 12: 780724. https://doi.org/10.3389/fmicb.2021.780724
  8. Simkovich A, Li Y, Kohalmi S, Griffiths G, Wang A* (2021) Molecular identification of prune dwarf virus (PDV) infecting sweet cherry in Canada and development of a PDV full-length infectious cDNA clone. Viruses 13 (10): 2025. https://doi.org/10.3390/v13102025
  9. Wang A* (2021) Cell-to-cell movement of plant viruses via plasmodesmata: A current perspective on potyviruses. Current Opinion in Virology 48: 10–16. https://doi.org/10.1016/j.coviro.2021.03.002
  10. Yang X, Li Y, Wang A* (2021) Research advances in potyviruses: from the laboratory bench to the field. Annual Review of Phytopathology 59: 1–29.  https://doi.org/1146/annurev-phyto-020620-114550
  11. Simkovich A, Kohalmi S, Wang A* (2021) First report of little cherry virus 1 infecting sweet cherry in Ontario, Canada. Plant Disease https://doi.org/10.1094/PDIS-04-21-0798-PDN
  12. Simkovich A, Kohalmi S, Wang A* (2021) First report of cherry virus A infecting sweet cherry in Ontario, Canada. New Disease Reports 44: e12022. https://doi.org/10.1002/ndr2.1202
  13. Zhang M, Gong P, Ge L, Chang Z, Cheng X, Zhou X, Wang A, Li F* (2021) Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity. New Phytologist (2021) 232: 1382–1398. https://doi.org/10.1111/nph.17657
  14. Qin L, Shen W, Tang Z, Hu W, Shangguan L, Wang Y, Tuo D, Li Z, Miao W, Valli AA, Wang A, Cui H* (2021) A newly identified virus in the family Potyviridae encodes two leader cysteine proteases in tandem that evolve contrasting RNA silencing suppression functions. Journal of Virology 95: e01414-20 https://doi.org/10.1128/JVI.01414-20

Activités professionnelles / intérêts

  • Compréhension des éléments d'interaction moléculaire virus-plante et des mécanismes d'expression et de réplication en génomique virale
  • Isolement moléculaire des facteurs de l'hôte et des gènes de résistance naturelle
  • Élaboration de nouvelles stratégies antivirales par la biotechnologie et avantages du recours aux virus des plantes
  • Formation des étudiants au doctorat et des chercheurs postdoctoraux 

Prix et études

Ph. D., Université de la Colombie-Britannique en 1999

Récolte d'or (innovation et excellence), Agriculture et Agroalimentaire Canada en 2010

Médaille du jubilé de diamant de la reine Elizabeth II, gouvernement du Canada, en 2013

Prix ​​de recherche exceptionnelle de la Société canadienne de phytopathologie en 2019

Ruth Allen Award, de la Société américaine de phytopathologie en 2019

Expérience et / ou de travail international

Recherche concertée avec des collègues en Chine, aux États-Unis et en France

Principales publications

  1. Patel V, Fall ML, Wang A, Ellouze W (2021) RNAi triggered systemic acquired resistance to combat emerging plant pathogens. The Joint Canadian Fungal Research Network (CanFunNet) and Great Lakes Mycology Conference 2021/05/26 - 2021/05/28, Western University, London, Ontario, Canada, p 90

    2021 - View publication details

  2. Qin, L., Shen, W., Tang, Z., Hu, W., Shangguan, L., Wang, Y., Tuo, D., Li, Z., Miao, W., Valli, A.A., Wang, A., Cui, H. (2021). A newly identified virus in the family potyviridae encodes two leader cysteine proteases in tandem that evolved contrasting RNA silencing suppression functions. Journal of Virology, [online] 95(1), http://dx.doi.org/10.1128/JVI.01414-20

    2021 - View publication details

  3. Harris, J.M., Balint-Kurti, P., Bede, J.C., Day, B., Gold, S., Goss, E.M., Grenville-Briggs, L.J., Jones, K.M., Wang, A., Wang, Y., Mitra, R.M., Sohn, K.H., Alvarez, M.E. (2020). What are the Top 10 Unanswered Questions in Molecular Plant-Microbe Interactions?, 33(12), 1354-1365. http://dx.doi.org/10.1094/MPMI-08-20-0229-CR

    2020 - View publication details

  4. Pollari, M., De, S., Wang, A., Mäkinen, K. (2020). The potyviral silencing suppressor HCPro recruits and employs host ARGONAUTE1 in pro-viral functions. PLoS Pathogens, [online] 16(10), http://dx.doi.org/10.1371/journal.ppat.1008965

    2020 - View publication details

  5. Li, F., Zhang, C., Tang, Z., Zhang, L., Dai, Z., Lyu, S., Li, Y., Hou, X., Bernards, M., Wang, A. (2020). A plant RNA virus activates selective autophagy in a UPR-dependent manner to promote virus infection. New Phytologist, [online] 228(2), 622-639. http://dx.doi.org/10.1111/nph.16716

    2020 - View publication details

  6. Dai, Z., He, R., Bernards, M.A., Wang, A. (2020). The cis-expression of the coat protein of turnip mosaic virus is essential for viral intercellular movement in plants. Molecular Plant Pathology, [online] 21(9), 1194-1211. http://dx.doi.org/10.1111/mpp.12973

    2020 - View publication details

  7. Chai, M., Wu, X., Liu, J., Fang, Y., Luan, Y., Cui, X., Zhou, X., Wang, A., Cheng, X. (2020). P3N-PIPO interacts with P3 via the shared N-Terminal domain to recruit viral replication vesicles for cell-to-cell movement. Journal of Virology, [online] 94(8), http://dx.doi.org/10.1128/JVI.01898-19

    2020 - View publication details

  8. Cui, H., Li, Y., Wang, A. 2172 155-163. http://dx.doi.org/10.1007/978-1-0716-0751-0_12

    2020 - View publication details

  9. Wu, G., Cui, X., Dai, Z., He, R., Li, Y., Yu, K., Bernards, M., Chen, X., Wang, A. (2020). A plant RNA virus hijacks endocytic proteins to establish its infection in plants. Plant Journal, [online] 101(2), 384-400. http://dx.doi.org/10.1111/tpj.14549

    2020 - View publication details

  10. Cui, H., Wang, A. (2019). The Biological Impact of the Hypervariable N-Terminal Region of Potyviral Genomes. Annual Review of Virology, [online] 6 255-274. http://dx.doi.org/10.1146/annurev-virology-092818-015843

    2019 - View publication details

  11. Griffiths, J., Lofano, A., Ellouze, W., Wang, A. (2019) Apple and apricot decline in Ontario. Plant Canada 2019, July 7-10. University of Guelph, Guelph, Ontario, Canada.

    2019 - View publication details

  12. Tran, H.H., Chen, B., Chen, H., Menassa, R., Hao, X., Bernards, M., Hüner, N.P.A., Wang, A. (2019). Development of a cucumber green mottle mosaic virus-based expression vector for the production in cucumber of neutralizing epitopes against a devastating animal virus. Journal of Virological Methods, [online] 269 18-25. http://dx.doi.org/10.1016/j.jviromet.2019.04.006

    2019 - View publication details

  13. Hu, W., Luo, H., Yang, Y., Wang, Q., Hong, N., Wang, G., Wang, A., Wang, L. (2019). Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1 and BdPV1. IMA Fungus, [online] 10(1), http://dx.doi.org/10.1186/s43008-019-0008-4

    2019 - View publication details

  14. Yang, K., Shen, W., Li, Y., Li, Z., Miao, W., Wang, A., Cui, H. (2019). Areca palm necrotic ringspot virus, classified within a recently proposed genus arepavirus of the family Potyviridae, is associated with necrotic ringspot disease in areca palm. Phytopathology, [online] 109(5), 887–894. http://dx.doi.org/10.1094/PHYTO-06-18-0200-R

    2019 - View publication details

  15. Zhang, F., Yang, Z., Hong, N., Wang, G., Wang, A., Wang, L. (2019). Identification and characterization of water chestnut Soymovirus-1 (WCSV-1), a novel Soymovirus in water chestnuts (Eleocharis dulcis). BMC Plant Biology, [online] 19(1), http://dx.doi.org/10.1186/s12870-019-1761-7

    2019 - View publication details

  16. Wu, X., Liu, J., Chai, M., Wang, J., Li, D., Wang, A., Cheng, X. (2019). The potato virus X TGBP2 protein plays dual functional roles in viral replication and movement. Journal of Virology, [online] 93(5), http://dx.doi.org/10.1128/JVI.01635-18

    2019 - View publication details

  17. Bujarski, J., Gallitelli, D., García-Arenal, F., Pallás, V., Palukaitis, P., Krishna Reddy, M., Wang, A. (2019). ICTV virus taxonomy profile: Bromoviridae. Journal of General Virology, [online] 100(8), 1206-1207. http://dx.doi.org/10.1099/jgv.0.001282

    2019 - View publication details

  18. Li, F., Zhang, C., Li, Y., Wu, G., Hou, X., Zhou, X., Wang, A. (2018). Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Nature Communications, [online] 9(1), http://dx.doi.org/10.1038/s41467-018-03658-2

    2018 - View publication details

  19. Li, F., Wang, A. (2018). RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLoS Pathogens, [online] 14(8), http://dx.doi.org/10.1371/journal.ppat.1007228

    2018 - View publication details

  20. Towards Development of Next Generation Resistance to Soybean Mosaic Virus. Kangfu Yu and Aiming Wang. Plant Biology Europe 2018, Copenhagen, Denmark. On June 17-21, 2018.

    2018 - View publication details

Installation de recherche

1391, rue Sandford
London, ON N5V 4T3
Canada

Affiliations

• Professeur auxiliaire du Département de biologie, Université Western
• Rédacteur en chef de la revue « Molecular Plant-Microbe Interactions »
• Rédacteur en chef adjoint des revues « PLoS Pathogens », « Journal of Virology » et « Virology »
• Membre à vie de l’American Society for Virology 
• Membre de l’International Society for Molecular Plant-Microbe Interactions
• Membre de la Société canadienne de phytopathologie 

Language

Anglais