Yaw (Chris) Siow

Wijekoon, C., Acharya, S.N., Siow, Y.L., Sura, S., Thandapilly, S., Sabra, A. (2021). Canadian sainfoin and fenugreek as forage and functional foods. Crop Science, [online] 61(1), 1-20. http://dx.doi.org/10.1002/csc2.20280

Shang, Y., Madduma Hewage, S., Wijerathne, C.U.B., Siow, Y.L., Isaak, C.K., Karmin, O. (2020). Kidney Ischemia-Reperfusion Elicits Acute Liver Injury and Inflammatory Response. Frontiers in Medicine, [online] 7 http://dx.doi.org/10.3389/fmed.2020.00201

Karmin O, Connie W.H. Woo, Victoria Sid, Yaw L. Siow,
Chapter 17 - Nonalcoholic fatty liver disease and use of folate,
Editor(s): Vinood B. Patel,
Molecular Nutrition,
Academic Press,
2020,
Pages 323-343,
ISBN 9780128119075,
https://doi.org/10.1016/B978-0-12-811907-5.00028-2.
(http://www.sciencedirect.com/science/article/pii/B9780128119075000282)
Abstract: Folate is an essential water-soluble B vitamin that is required for nucleic acid biosynthesis, methylation reaction, and sulfur-containing amino acid metabolism. Depletion of folate perturbs folate-dependent one-carbon metabolism and is associated with nonalcoholic fatty liver disease (NAFLD). NAFLD is a common chronic liver disease and its prevalence increases significantly in patients with obesity and/or type 2 diabetes mellitus. As the incidence of obesity and diabetes continues to rise, NAFLD will emerge as a major threat to public health. Low serum folate levels are correlated with body mass index, severity of NAFLD, and diabetes. There is currently no approved pharmacological agent for NAFLD treatment. Nutrition-focused therapies represent a promising management strategy for metabolic diseases such as NAFLD. Understanding the role of folate in fatty liver disease may position this vitamin as a potential therapy for NAFLD.
Keywords: Folate; folic acid; nonalcoholic fatty liver disease (NAFLD); liver; folate transporter; obesity; supplementation; sulfur-containing amino acid

Madduma Hewage, S., Prashar, S., O, K. and Siow, Y.L. (2019) Lingonberry supplementation improves hyperlipidemia induced by high-fat diet. CCARM Rapid-Fire Research Symposium 2, Winnipeg, March 29, 2019.

Sid, V., Siow, Y.L., Shang, Y., Woo, C.W., Karmin, O. (2018). High-fat diet consumption reduces hepatic folate transporter expression via nuclear respiratory factor-1. Journal of Molecular Medicine, [online] 96(11), 1203-1213. http://dx.doi.org/10.1007/s00109-018-1688-8

Sid, V., Shang, Y., Siow, Y.L., Hewage, S.M., House, J.D., Karmin, O. (2018). Folic Acid Supplementation Attenuates Chronic Hepatic Inflammation in High-Fat Diet Fed Mice. Lipids, [online] 53(7), 709-716. http://dx.doi.org/10.1002/lipd.12084

Madduma Hewage, S., Sid, V., Prashar, S., Shang, Y., O, K. and Siow, Y.L. (2018) Manitoba lingonberry supplementation improves lipid profile in metabolic disorder. St. Boniface Albrechtsen Research Centre R30 Conference, Winnipeg, April 21, 2018

O K, Sid V, Shang Y, and Siow YL (2017) Fatty Liver: It is not just about fat - Nutritional impact on non-alcoholic fatty liver disease (NAFLD). 2017 International Tropical Agriculture Conference. November 20-22, 2017 Brisbane, Australia, Abstract 176, Symposium Invited Talk.

Sid V, Shang Y, Siow YL, and O K (2017) Dietary Regulation of inflammatory response in Non-alcoholic fatty liver disease. Canadian Cardiovascular Congress, October 21-24, Vancouver, Canada, Canadian Journal of Cardiology 33(10) Suppl: S27-28