Sijo Joseph (Thandapilly), Ph.D.

Image Sijo Joseph (Thandapilly)
Research Scientist

Investigating the nutritional and anti-nutritional bioactive components from agricultural based resources and their impact on human health. Developing novel methodologies for the study of carbohydrate and or protein, oil and minor components structure function, and their utilization for improvement of cereal grain end products.

Current research and/or projects

  • Investigating the Potential of Avenanthramides on Glycemic Control- a Novel Marketable Attribute for Manitoba Oats

  • Developing a platform comprising novel experimental tools for improving the health benefits of Canadian agricultural products.

  • Assessment of in vitro digestibility and predicted glycemic response of oat products using a modified Englyst method and a dynamic stomach model.

  • AIP Pulse Cluster: Evaluation of protein digestibility and glycemic response of pulse based products using in vitro experimental platform.

 

Education and awards

2007 – 2012      University of Manitoba, Canada                                                 Ph.D. (Physiology)

2002– 2004      Bharathiar University, India                                                   M.Sc. (Biotechnology)

1999– 2002      University of Calicut, India                                                             B.Sc. (Chemistry)

Scholarships/Research awards

2012-2014                   NSERC, Canada Post-doctoral visiting fellowship

2012-2013                   Manitoba Health Research Council PhD Studentship (declined)

2010-2012                   Manitoba Health Research Council PhD Studentship

2011

  • Best oral presentation Award at Functional Foods and Nutraceutical Symposium

2010                           

  • Dr. Grant Pierce Award for Excellence in Cardiovascular Physiology
  • Have a Heart Bursary Award from Canadian Cardiovascular society
  • Award of excellence in the CIHR National level Poster competition
  • Best Poster Presentation at Manitoba Health Research Poster competition
  • International Graduate student scholarship

2009                           

  • Best Poster Presentation Award from Institute of Cardiovascular Sciences
  • Rated second in the Fletcher Gordon PhD Fellowship
  • International Graduate Student Scholarship

2007                           

  • ICS Studentship Award from Institute of Cardiovascular Sciences
  • International Graduate Student Entrance Scholarship

Travel Awards

2012                           

  • Canadian Oxidative Stress Consortium travel award
  • University of Manitoba Graduate student Travel award

2011                           

  • Canadian Hypertension Society travel award
  • University of Manitoba Graduate student Travel award

2009                           

  • Graduate student International travel award
  • Manitoba Agri-Health Research Network International Travel Award

Key publications

For a complete list of publications, please visit: AAFC Online

Refereed publications:

  1. AS Khorshidi, N Ames, R Cuthbert, E Sopiwnykd, SJ Thandapilly. Study of a low-1 intensity ultrasound technique for discrimination of Canadian strong wheat varieties. Food Research International (under review).

  2. Y Wang, SV Harding, SJ Thandapilly, SM Tosh, PJH Jones, NP Ames. Barley b-glucan reduces blood cholesterol levels via interrupting bile acid metabolism. British Journal of Nutrition. 2017 Nov;118(10):822-829.

  3. SP Ndou, E Kiarie, SJ Thandapilly, N Ames, CM Nyachoti. Dietary fiber types modulate gut fermentation, growth performance and lipid metabolism in growing pigs. Journal of Animal Science. 2017 Jul;95(7):3068-3078.

  1. L Malunga, SJ Thandapilly. N Ames. Cereal derived phenolic acids and intestinal alpha glucosidase activity inhibition: Structural activity relationship. Journal of Food Biochemsitry (Accepted for publication).
  2. AS Khorshidi, SJ Thandapilly, N Ames. Application of low-intensity ultrasound as a rapid, cost-effective tool to wheat screening. I. A systematic frequency selection. Journal of Cereal Science (In press).
  3. LN Malunga, Masatcioglu MT,  AS Khorshidi, SJ Thandapilly, RD Cuthbert, NP Ames, MG Scanlon. Free Asparagine Concentrations in Canadian Hard Red Spring Wheat Cultivars. Canadian Journal of Plant Science. (under review).
  4. < > Thandapilly, P Raj, XL Louis, D Perera, P Yamanagedara, P Zahradka, CG Taylor, T Netticadan (2016). Canola oil rich in oleic acid improves diastolic heart function in diet-induced obese rats. Journal of Physiological Science. 2017 May;67(3):425-430.K Cuvelier, J Storsley, R Mollard, SJ Thandapilly,  N Ames.  A review of impact of pulses on postprandial glycemic response in humans. Cereal Foods World. 2017, 62 (2):53-58. https://doi.org/10.1094/CFW-62-2-0053
  5. AS Khorshidi, L Malunga, J Storsley, SJ Thandapilly, N Ames. A Review of Conventional and New Potential Techniques for Screening Wheat Genotypes for Quality. Cereal Chemistry. March 3, 2018.
  6. SJ Thandapilly, Y Wang, SP Ndou, CM Nyachoti, NP Ames. High molecular weight barley β-glucan diet increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals. Journal of Food and Function (Under review).

  7. S AbuMweis, SJ Thandapilly, J Storsley, Ames N. (2016). Meta-analysis of human postprandial glycemic response to consumption of barley and barley β-glucan. Journal of Functional Foods- 27 (2016) 329–342.

  8. A Movahed, A Ostovar, D Iranpour, SJ Thandapilly, P Raj, XL Louis, JM Smoliga, T Netticadan (2016). "The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial. Trials, 17(296), pp. 1-8.

  9. N Ames, J Storsley, SJ Thandapilly (2016). 2016, volume 61(5), 184-187.

  10. X Wang, Y Chu, J Storsley, SJ Thandapilly,N Ames. Effects of Processing, Cultivar, and Environment on the Physicochemical Properties of Oat b-Glucan. Cereal Chemistry 93(4), pp. 402-408.

  11. VR Ramprasath, SJ Thandapilly, S Yang, A Abraham, PJ Jones, N Ames. Effect of consuming novel foods consisting high oleic canola oil, barley beta glucan and DHA on cardiovascular disease risk in humans - the CONFIDENCE (canola oil and fibre with DHA enhanced) study. Trials. 2015 Oct 31;16(1):489. doi: 10.1186/s13063-015-1014-5.

  12.  NM Ibrahim, SJ Thandapilly, Y Jia, T Netticadan, H Aukema. Beneficial effects of dietary fish oil and soy protein on the reno-cardiac syndrome in the Han:SPRD-Cy rat model of cystic kidney disease. Lipids. 2016 May;51(5):635-42.

  13. Y Wang, Eck P, SJ Thandapilly, SE Harding, SM Tosh, PJ Jones, NP Ames. The CYP7A1 SNP rs3808607-G allele is associated with lowered circulating cholesterols biomarkers during intervention with high molecular weight β-glucan. Journal of Nutrition 2016 Apr;146(4):720-7.

  14. N Ames, H Blewett, J Storsley, SJ Thandapilly, P Zahradka, C Taylor. A double-blind randomized controlled trial testing the effect of barley tortillas containing varying amounts of amylose, β-glucan and insoluble fibre on the post-prandial glucose response of healthy volunteers. British Journal of Nutrition. 2015 Apr 8:1-11.

  15. SJ Thandapilly. Why a new journal, Diabesity- editorial perspectives. Diabesity.2015; DOI: 10.15562/diabesity.2015.7. Editorial publication.

  16. P Raj, X L Louis, SJ Thandapilly, A Movahed, S Zieroth, T Netticadan. Potential of resveratrol in preventing the development of heart disease and failure. Life Sciences. 2014; 30;95:63-71.

  17. XL Louis, SJ Thandapilly, M Vinqvist, L Yu, H le, W Kalt, T Netticadan. Blueberry phenolic fraction prevents cardiomyocyte injury by preventing calpain activation and oxidative stress. Food and Function. 2014 Jul 23;5(8):1785-94.

  18. A Movahed, I Nabipour, XL Louis, SJ Thandapilly, L Yu, M Kalantarhormozi, SJ Rekabpour, T Netticadan. improves lipid profile in patients with type 2 diabetes. Evidence-Based Complementary and Alternative Medicine. 2013; 2013:851267.

  19. SV Harding, J Storsley, SJ Thandapilly, N Ames. Lower serum insulin in healthy Sprague-Dawley rats consuming chips from specific barley flour blends. Cereal Chemistry 2013. 90,5: 474-479.

  20. SJ Thandapilly, XL Louis, J Behbahani, A Movahed, L Yu, R Fandrich, S Zhang, E Kardami, HD Anderson, T Netticadan. Lowered hemodynamic load aids resveratrol in reversing cardiovascular defects in hypertensive rats. Hypertension Research. 2013 Jun 20. doi: 10.1038/hr.2013.55.

  21. SJ Thandapilly, JL LeMaistre, XL Louis, CM Anderson, T Netticadan, HD Anderson. Vascular and cardiac effects of grape powder in the spontaneously hypertensive rat. American Journal of Hypertension. 2012 Oct;25(10):1070-6.

  22. XL Louis, R Murphy, SJ Thandapilly, L Yu, T Netticadan.Garlic extracts prevents oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulphide. BMC Complementary and Alternative Medicine. 2012 Aug 29;12:140.

  23. A Movahed, L Yu, SJ Thandapilly, XL Louis, T Netticadan.Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury. Archives of Biochemistry and Biophysics. 2012 Nov 15;527(2):74-80.

  24. XL Louis, SJ Thandapilly, SK SureshKumar, L Yu, C Taylor, P Zahradka and T Netticadan. Resveratrol improves cardiac function in obese prone but not obese resistant rats on a high fat diet. Journal of Nutritional Biochemistry.2011 Nov 30 2012 Sep;23(9):1163-9..

  25. SJ Thandapilly. XL Louis, , L Yu, T Yang, D M  Stringer, D Y-C. Cheung, S Zhang, J Wigle, E Kardami, P Zahradka and T Netticadan. Resveratrol prevents norepinephrine induced hypertrophy in adult cardiomyocytes. European Journal of Pharmacology, 2011. 2011 Oct 1;668(1-2):217-24.

  26. M Baarine*, SJ Thandapilly*, X Louis, L Yu, D Delmas , T Netticadan  , G Lizard , N Latruffe. Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumour and on normal cardiac cells. Genes and Nutrition, 2011 May;6(2):161-9.

  27. J Behbahani, SJ Thandapilly, XL Louis, Y Huang, Z Shao, MA Kopilas, P Wojciechowski, T Netticadan, HD Anderson. Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive RatAmerican Journal of Hypertension, 2010. Dec; 23(12):1273-8.

  28. D Juric, X Yao, SJ Thandapilly, X Louis, E Cantor, B Chaze, P Wojciechowski, Z Vasanji, T Yang, J Wigle, and T Netticadan. Experimental Physiology.

  29. P Wojciechowski, X Louis, SJ Thandapilly, and T Netticadan. Potential of resveratrol in the treatment of heart failure. Current Chemical Biology. 2010; 4:1, 84-88.

  30. P Wojciechowski, D Juric, XL Louis, SJ Thandapilly, L Yu, C Taylor, T Netticadan Resveratrol arrests and regresses the development of pressure overload but not volume overload induced cardiac hypertrophy in rats. Journal of Nutrition 2010 May;140(5):962.

  31. SJ Thandapilly, Wojciechowski P, Behbahani J, Louis XL, Yu L, Juric D, Kopilas MA, Anderson HD, Netticadan T. Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure. American Journal of Hypertension. 2010 Feb;23(2):192-6.

     

    Book chapter:

 

  • Ames N, Storsley J, Thandapilly SJ, Functionality of Beta-Glucan from Oat and Barley as it relates to health. Carbohydrates & Phytochemical Components in Cereal Grain-Based Functional Foods. 2018. Publisher:  Royal Society of Chemistry (RSC), United Kingdom.

Affiliations

Research Scientist, Agriculture and Agri-Food Canada   

Adjunct Professor, Department of Human Nutritional Sciences, University of  Manitoba, Canada

Language

English