Sandra Clarke, Ph.D.

Image Sandra Clarke
Research Scientist

Food Attributes and Gut Health

Current research and/or projects

  • Validating agri-food products wheat bran and grape pomace as functional food ingredients for gut health
  • Value-added use of hemp seed and processing fractions for improved food attributes
  • Effects of milk and yogurt supplementation on bone health and body composition in Canadian young adults
  • Validation of pilus vaccine for necrotic enteritis control in poultry

Research and/or project statements

Dr. Clarke's research has been focused on investigating the impacts of dietary supplements and food components on gut health and the microbiota. Dr. Clarke's work is linked with the AAFC strategic area of "improving attributes for food and non-food uses", and continues to explore food ingredients for potential to decrease gut-level inflammation, maintain a balanced and diverse intestinal microbiome community structure and support overall health.

Professional activities / interests

  • Immunology, intestinal health and systemic/mucosal inflammation
  • Identifying diet-microbiota-immune impacts on intestinal health and describing diet-mediated effects on gut microbiome community structure
  • Characterizing value-added ingredients to maintain and support gut health

Education and awards

Post-Doctoral Research Fellowship, Agriculture, Food & Nutrition Science Department, Faculty of Agricultural, Life and Environmental Science, University of Alberta, 2017-2019

Doctor of Philosophy, Applied Bioscience – Immunology, University of Ontario Institute of Technology, 2016

International experience and/or work

  • Recipient of AAFC's International Opportunities Program funding to work on a project titled "Pulse Snack Foods with Health Benefits" in collaboration with researchers from Turkey, 2022-2023.

Key publications

  1. Lange, M.E., Clarke, S.T., Boras, V.F., Brown, C.L.J., Zhang, G., Laing, C.R., Uwiera, R.R.E., Montina, T., Kalmokoff, M.L., Taboada, E.N., Gannon, V.P.J., Metz, G.A.S., Church, J.S., Inglis, G.D. (2023). Commensal Escherichia coli Strains of Bovine Origin Competitively Mitigated Escherichia coli O157:H7 in a Gnotobiotic Murine Intestinal Colonization Model with or without Physiological Stress. Animals, [online] 13(16),

    2023 - View publication details

  2. Clarke, S.T.; Sarfaraz, S.; Qi, X.; Ramdath, D.G.; Fougere, G.C.; Ramdath, D.D. A Review of the Relationship between Lentil Serving and Acute Postprandial Blood Glucose Response; Effects of Dietary Fibre, Protein and Carbohydrates. Nutrients 2022, 14, 849.

    2022 - View publication details

  3. Bescucci, D.M., Clarke, S.T., Brown, C.L.J., Boras, V.F., Montina, T., Uwiera, R.R.E., Inglis, G.D. (2020). The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathogens, [online] 12(1),

    2020 - View publication details

  4. Sarfaraz, S., Singh, S., Hawke, A., Clarke, S.T., Ramdath, D.D. (2020). Effects of high-fat diet induced obesity and fructooligosaccharide supplementation on cardiac protein expression. Nutrients, [online] 12(11), 1-23.

    2020 - View publication details

  5. McCarville, J.L., Clarke, S.T., Shastri, P., Liu, Y., Kalmokoff, M., Brooks, S.P.J., Green-Johnson, J.M. (2013). Spaceflight Influences both Mucosal and Peripheral Cytokine Production in PTN-Tg and Wild Type Mice. PLoS ONE, [online] 8(7),

    2013 - View publication details

Research facility

93 Stone Road West
Guelph, ON N1G 5C9


  • Adjunct Professor, Faculty of Science and Applied Bioscience Graduate Program, Ontario Tech University
  • Special Graduate Faculty, Department of Food Science, University of Guelph
  • American Association of Immunologists (member)