Pierre Lacasse

Image Pierre Lacasse
Research Scientist

Dr Pierre Lacasse has obtained a Ph.D. in Animal Science from McGill University in 1993.

In 1994, he did a postdoc at Ruakura Agricultural Research Centre in Hamilton, New Zealand; where he investigated the relationship between mammary gland blood flow and milk production.

Since 1995, he is a research scientist in Biology of lactation for Agriculture and Agri-Food Canada at the Sherbrooke Research and Development Centre in Sherbrooke, Québec. His current research program focus on the biological control of lactation persistency, factors controlling milk synthesis, effect of dairy cow management on productivity and susceptibility to diseases and the development of new tools to fight mastitis.

He is one of the founding member and leaders of the Canadian Bovine Mastitis and Milk Quality Research Network.

Agriculture and Agri-Food Canada

Current research and/or projects

  • Dairy cow management for the next generation.
  • Biological control of lactation persistency.
  • Improvement of dairy cow resistance to disease.
  • Prevention of intramammary infection at drying-off by the stimulation mammary gland immunity.
  • Development of alternative to antibiotics for the prevention and treatment of bovine mastitis.

Professional activities / interests

  • Theme leader and executive member of the Canadian Bovine Mastitis and Milk Quality Research Network.
  • Theme leader and executive member of OP+Lait, Regroupement québécois pour un lait de qualité optimale.
  • Éditor for the scientific journal Animal: an international journal of animal bioscience.
  • Executive and program Committee Member of the NSERC-CREATE on milk quality.

Education and awards

  • 2005 Canadian Society of Animal Science Award for Technical Innovation in Enhancing Production of Safe Affordable Food.
  • 2006 Institut National de la Recherche Agronomique (INRA) Bourse pour séjour scientifique de haut niveau.

International experience and/or work

1994-1995                  Postdoctoral fellow at Ruakura Research Centre, Hamilton, New Zealand.

2006-2007                 Visiting scientist at INRA, St-Gilles, France.

 

Key publications

For a complete list of publications, please visit: AAFC Online

Patents

7. Malouin, F., Allard, M., Lebeau Jacob, C., Talbot, B., Scholl, D., Lacasse, P., Diarra, M.S., Ster., C., July 24 2018. Bacterial vaccine components and uses thereof. US Pat. 10,029,004 B2.

6. Lacasse, P., S. Lanctôt, P. Fustier, A. Bégin, B. Bisakowski and A. Taherian. Filed February 16th 2017. Method for accelerating involution and preventing infection of the mammary gland at drying-off. Her Majesty the Queen, assignee. PCT patent application No PCT/CA2017/050339.

5. Malouin, F., Allard, M., Lebeau Jacob, C., Talbot, B., Scholl, D., Diarra, M.S., Ster., C., Lacasse, P. February 14 2017. Bacterial vaccine components and uses thereof. US Pat. 9,566,322 B2.

4. Lacasse, P., S. Lanctôt, P. Fustier, A. Bégin, B. Bisakowski and A. Taherian. 2016. Method for prevention of mammary gland infection at drying-off. Her Majesty the Queen, assignee. Provisional US patent application No 62/310,013 (62/310,025).

3. Malouin, F., Allard, M., Lebeau Jacob, C., Talbot, B., Scholl, D., Diarra, M.S., Ster., C., Lacasse, P. November 18 2014 Bacterial vaccine components from Staphylococcus aureus and uses thereof. US Pat.8,889,150 B2.

2. Schaefer, A.L., Scott, S., P. Lacasse, A. K. W. Tong, inventors. 2007. Early detection of inflammation using infrared thermography. Her Majesty the Queen, assignee. US Pat. 7,277,744 B2.

1. Diarra, M. S., P. Lacasse and D. Petitclerc, inventors. 1999. Method for treatment and/or prevention of antibiotic-resistant microorganism infections.   Her Majesty the Queen, assignee. PCT/CA00/01517.

Reviews

17. X. Zhao, B. Ponchon, S. Lanctôt, and Lacasse, P. 2019. Accelerating mammary gland involution after drying-off in dairy cattle. Journal of Dairy Science (Accepted).

16. Boutinaud, M.,  L. Herve, H. Quesnel, V. Lollivier, L. Finot, F. Dessauge,E. Chanat, P. Lacasse, C. Charton, J. Guinard-Flament. 2018. The cellular mechanisms underlying mammary tissue plasticity during lactation. Animal (Accepted)

15. Lacasse, P., X. Zhao, N. Vanacker, and M. Boutinaud. 2019. Review: Inhibition of prolactin as a management tool in dairy husbandry. Animal (Accepted).

14. Lacasse, P., N. Vanacker, S. Ollier, and C. Ster. 2018. Innovative dairy cow management to improve resistance to metabolic and infectious diseases during the transition period. Research in Veterinary Science 116:40-46 DOI: 10.1016/j.rvsc.2017.06.020

13. Francoz, D., V. Wellemans, J.P. Dupré, H. J. Karreman, J.P. Roy, F. Labelle, P. Lacasse,  and S. Dufour. 2017. A Systematic Review of Non-Antimicrobial for Clinical Mastitis Treatment in Dairy Cows. Journal of Dairy Science 100:7751-7770. DOI: 10.3168/jds.2016-12512

12. Hurley, W.L., J.J. Loor, and P. Lacasse. 2016. Growth, Development and Involution. Reference Module in Food Sciences. Elsevier, pp. 1–8. doi: http://dx.doi.org/10.1016/B978-0-08-100596-5.21408-X

11. Francoz, D., V.Wellemans, J.-P. Roy, P. Lacasse, A. Ordonez-Iturriaga, F. Labelle, and S. Dufour. 2016. Non-antibiotic approaches at drying-off for treating and preventing intramammary infections: a protocol for a systematic review and meta-analysis. Animal Health Research Reviews 17: 169–175.

10. Lacasse, P., S. Ollier, V. Lollivier, and M. Boutinaud.  2016. New insights in the importance of prolactin in dairy ruminants. Journal of Dairy Science 99:864-874.

9. Lacasse, P., V. Lollivier, F. Dessauge, R.M. Bruckmaier, S. Ollier, and M. Boutinaud.  2012. New developments on the galactopoietic role of prolactin in dairy ruminants. Domestic Animal Endocrinology 43:154–160

Scientific papers (peer review)

90. Vanacker, N., C.L Girard, R. Blouin, and P. Lacasse. 2019. Effects of feed restriction and supplementary folic acid and vitamin B12 on immune cell functions and blood cell populations in dairy cows. Animal (Submitted)

89. Lacasse, P., X. Zhao, and S. Ollier. 2019. Effect of stage of lactation and gestation on milking-induced hormone release in lactating dairy cows. Domestic Animal Endocrinology 66:72-85. DOI:  https://doi.org/10.1016/j.domaniend.2018.10.003

88. Krug, C., P. A. Morin, P. Lacasse, J. P. Roy, J. Dubuc, and S. Dufour. 2018. A randomized controlled trial on the effect of incomplete milking during the first five days in milk on reproductive performance of dairy cows. Journal of Dairy Science 101: 11330–11341. DOI: https://doi.org/10.3168/jds.2018-14909

87. Krug, C., P. A. Morin, P. Lacasse, J. P. Roy, J. Dubuc, and S. Dufour. 2018. Effect of incomplete milking during the first 5 days in milk on udder and reproductive tract health: Results from a randomized controlled trial. Journal of Dairy Science 101(10):9275-9286. DOI: https://doi.org/10.3168/jds.2018-14713

86. Krug, C., P.-A. Morin, P. Lacasse, D. Santschi, J.-P. Roy, J. Dubuc, and S. Dufour. 2018. A randomized controlled trial on the effect of incomplete milking during the first five days in milk on culling hazard and on milk production and composition of dairy cows. Journal of Dairy Science 101:4513-4526. DOI: https://doi.org/10.3168/jds.2017-14021

85. Tong, J.J., I. M. Thompson, X. Zhao, and P. Lacasse. 2018. Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows. Journal of Dairy Science 101:2588-2601. DOI: https://doi.org/10.3168/jds.2017-13353

84. Tong, J.J., I. M. Thompson, X. Zhao, and P. Lacasse. 2018. Effect of the concentration of circulating prolactin on dairy cows’ responsiveness to domperidone injection. Journal of Dairy Science 101:2579-2587. DOI: http://dx.doi.org/10.3168/jds.2017-13828

83. Morin, P.-A., C. Krug, Y. Chorfi, J. Dubuc, P. Lacasse, J.-P. Roy, D. Santschi, and S. Dufour. 2018. Efficacy of an incomplete milking protocol during the early lactation for reducing ketonemia, prevalence of hyperketonemia, and loss of body condition in commercial dairy cows: a randomized controlled trial. Journal of Dairy Science 101:4367-4377. DOI: https://doi.org/10.3168/jds.2017-13151

82. Ponchon, B., X. Zhao, Ollier, S., and P. Lacasse. 2017. Effects of photoperiod modulation and melatonin feeding around drying-off on bovine mammary gland involution. Journal of Dairy Science 100:8496-8506. DOI: http://dx.doi.org/10.3168/jds.2016-12272

81. Asli, A., E. Brouillette, C. Ster, M. G. Ghinet, R. Brzezinski, P. Lacasse, M. Jacques, F. Malouin. 2017. Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis. PLOS One 12:e0176988. DOI: 10.1371/journal.pone.0176988

80. Vanacker, N., S. Ollier, F. Beaudoin, R. Blouin, and P. Lacasse. 2017. Effect of inhibiting the lactogenic signal at calving on milk production and metabolic and immune perturbations in dairy cows. Journal of Dairy Science 100:5782-5791 DOI: 10.3168/jds.2017-12570

79. Ponchon, B., X. Zhao, Ollier, S., and P. Lacasse. 2017. Relationship between glucocorticoids and prolactin during mammary gland stimulation in dairy cows. Journal of Dairy Science 100: 1521-1534.

78. Do, D. N., N. Bissonnette, P. Lacasse, F. Miglior, M. Sargolzaei, X. Zhao, and E. M. Ibeagha-Awemu. 2017. Genome-wide association analysis and pathways enrichment for lactation persistency in Canadian Holstein cattle. Journal of Dairy Science 100:1955-1970.

77. Lanctôt, S., P. Fustier, A. R. Taherian, B. Bisakowski, X. Zhao, and P. Lacasse. 2017. Effect of intramammary infusion of chitosan hydrogels at drying-off on bovine mammary gland involution. Journal of Dairy Science 100:2269-2281.

76. Taherian, A. R., P. Lacasse, B. Bisakowski, M. Pelletier, S. Lanctôt, and P. Fustier. 2017. Rheological and thermogelling properties of commercial chitosan/Beta-glycerophosphate : retention of hydrogels in water, milk and UF-milks. Food Hydrocolloids 63:635-645.

75. Ollier, S., F. Beaudoin, N. Vanacker, and P. Lacasse. 2016. Effect of reducing milk production using a prolactin-release inhibitor or a glucocorticoid on metabolism and immune functions in cows subjected to acute nutritional stress. Journal of Dairy Science 99:9949-9961.

74. Lollivier, V., P. Lacasse, J. Angulo Arizala, P. Lamberton, S. Wiart, J. Portanguen, R. Bruckmaier, and M. Boutinaud. 2015. In vivo inhibition followed by exogenous supplementation demonstrates galactopoietic effects of prolactin on mammary tissue and milk production in dairy cows. Journal of Dairy Science 98:8775-8787.

73. Lacasse, P., and S. Ollier, 2015. The dopamine antagonist domperidone increases prolactin concentration and enhances milk production in dairy cows. Journal of Dairy Science 98:7856-7864.

72. Ollier, S., X. Zhao, and P. Lacasse. 2015. Effects of feed restriction and prolactin-release inhibition at drying-off on susceptibility to new intramammary infection in cows. Journal of Dairy Science 98:221-228.

71. Veh K. A., R. Contelli Klein, C. Ster, G. Keefe, P. Lacasse, D. Scholl, J. P. Roy, D. Haine, S. Dufour, B.G. Talbot, A. Ribon, and F. Malouin. 2015. Genotypic and Phenotypic characterization of Staphylococcus aureus causing persistent and non-persistent subclinical bovine intramammary infections during lactation or the dry period. Journal of Dairy Science 98:155-168.

70. Ollier, S., X. Zhao, and P. Lacasse. 2014. Effects of feed restriction and prolactin-release inhibition at drying-off on metabolism, and mammary gland involution in cows. Journal of Dairy Science 97: 4942–4954.

69. Lacasse, P., C. Vinet, and D. Petitclerc. 2014. Effect of prepartum photoperiod and melatonin feeding on milk production and prolactin concentration in dairy heifers and cows. Journal of Dairy Science 97:3589-3598.

68. Lacasse, P., and S. Ollier. 2014. Effect of premilking stimulation and milking frequency on milking-induced prolactin release in lactating dairy cows. Domestic Animal Endocrinology 47 :47-54.

67. M. F. Palin, C. Côrtes, C. Benchaar, P. Lacasse, and H. V. Petit. 2014. mRNA Expression of lipogenic enzymes in mammary tissue and fatty acid profile in milk of dairy cows fed flax hulls and infused with flax oil in the abomasum. British Journal of Nutrition 111:1011-1020.

66. Ponchon, B., P. Lacasse, N. Silanikove, Ollier, S., and X. Zhao. 2014. Effects of intra-mammary infusions of casein hydrolysate, EGTA and lactose at drying-off on mammary gland involution. Journal of Dairy Science 97:779-788.

65. Bachmann Schogor, A. L., M. F. Palin, G. Tadeu dos Santos, C. Benchaar, P. Lacasse, and H. V. Petit. 2013. Mammary gene expression and activity of antioxidant enzymes and oxidative indicators in blood, milk, mammary tissue and ruminal fluid of dairy cows fed flax meal. British Journal of Nutrition 110:1743–1750.

64. Ollier, S., X. Zhao, and P. Lacasse. 2013. Effect of prolactin-release inhibition on milk production and mammary gland involution at drying-off in cows. Journal of Dairy Science 96:335-343

63. Allard, M., C. Ster, C.L. Jacob, D. Scholl, M.S. Diarra, P. Lacasse, F. Malouin.  2013. The expression of a putative exotoxin and an ABC transporter during bovine intramammary infection contributes to the virulence of Staphylococcus aureus. Veterinary Microbiology 162:761–770

62. Ster C., M. Allard, S. Boulanger, M. Lamontagne Boulet, J. Mulhbacher, D. A. Lafontaine, É. Marsault, P. Lacasse, F. Malouin.  2013. Experimental Treatment of Staphylococcus aureus Bovine Intramammary Infection Using a Guanine Riboswitch Ligand Analog. Journal of Dairy Science 96:1000-1008

61. Ben Chedly, H., P. Lacasse, P-G Marnet, and M. Boutinaud. 2013. The decrease in milk yield during once daily milking is due to regulation of synthetic activity rather than apoptosis of mammary epithelial cells in goats. Animal 7 :124-133

60. Carbonneau, E., A.M. de Passillé, J. Rushen, B. G.Talbot, P. Lacasse. 2012. The effect of incomplete milking or nursing on milk production, blood metabolites and immune functions of dairy cows. Journal of Dairy Science 95:6503-6512

59. Ster, C., M.C. Loiselle, and P. Lacasse.  2012. Effect of postcalving serum nonesterified fatty acids concentration on the functionality of bovine immune cells. Journal of Dairy Science 92:708-717

58. Côrtes, C., M. F. Palin, N. Gagnon, C. Benchaar, P. Lacasse, S. Tao, and H. V. Petit. 2012. Mammary gene expression and activity of antioxidant enzymes and concentration of the mammalian lignan enterolactone in milk and plasma of dairy cows fed flax lignans and infused with flax oil in the abomasum. British Journal of Nutrition 108:1390-1398.

57. Boutinaud, M., V. Lollivier, R.M. Bruckmaier, Y.R. Boisclair, G.F. Wagner, and P. Lacasse.  2012. Mammary cell activity and turnover in dairy cows treated with the prolactin-release inhibitor quinagolide and milked once-daily. Journal of Dairy Science 95:177-187.

56. Borucki, S., R. Berthiaume, A. Robichaud, and P. Lacasse. 2012. Effects of iodine intake and teat dipping practices on milk iodine concentrations in dairy cows. Journal of Dairy Science 95:213-220

55. Bernier-Dodier, P, C. L. Girard, B.G. Talbot, P. Lacasse. 2011. Impact of dry period management on mammary gland function and its endocrine regulation. Journal of Dairy Science 94:4922-4936.

54. Borucki, S., P. Lacasse, A. Fouquet, F. Beraldin, A. Robichaud, and R. Berthiaume. 2011. Feed iodine concentrations on farms with contrasting levels of iodine in milk. Journal of Dairy Science 94: 4684-4689

53. Lacasse, P., V. Lollivier, R.M. Bruckmaier, Y.R. Boisclair|, G.F. Wagner, and M. Boutinaud.  2011. Effect of the prolactin-release inhibitor quinagolide on lactating dairy cows. Journal of Dairy Science 94:1302-1309.

52. Ben Chedly, H., P. Lacasse, P-G Marnet, M. Komara, S. Marion, and M. Boutinaud. 2011. Use of milk epithelial cells to study regulations of cell activity and apoptosis during once daily milking in goats. Animal 5:572-579.

51. Borucki, S., R. Berthiaume, A. Fouquet, F. Beraldin, A. Robichaud, and P. Lacasse. 2010. Iodine levels in milk from Canadian farms. Journal of Food Protection 73:1658-1663.

50. Villeneuve, L., D. Cinq-Mars, and P. Lacasse.2010. Effects of restricted feeding of prepubertal ewe lamb on reproduction and lactation performances over two breeding seasons Animal 4:1997-2003.

49. Ben Chedly, H., M. Boutinaud, P. Bernier-Dodier, P-G Marnet, and P. Lacasse.  2010. Disruption of cell junctions induces apoptosis and reduces synthetic activity in lactating goat mammary gland. Journal of Dairy Science 93:2938-2951.

48. Ster C, F. Beaudoin, M. S. Diarra, M. Jacques, F. Malouin, and P. Lacasse. 2010. Evaluation of some Staphylococcus aureus iron-regulated proteins as vaccine targets. Veterinary Immunology and Immunopathology 136:311-318

47. Villeneuve, L., D. Cinq-Mars, and P. Lacasse. 2010. Effects of restricted feeding of prepubertal ewe lamb on growth performance and mammary gland development. Animal 4: 944–950.

46. Bernier-Dodier, P., L. Delbecchi, G. F. Wagner, B. G. Talbot, and P. Lacasse. 2010. Effect of milking frequency on lactation persistency and mammary gland remodeling in mid-lactation cows. Journal of Dairy Science 94:555-564.

Affiliations

  • Adjunct Professor, Department of Biology, University of Sherbrooke.
  • Adjunct Professor, Department of Animal Science, McGill University.
  • Member of the American Dairy Science Association.
  • Member of the Canadian Society of Animal Science.

Language

English
French