Paul A. White, PhD

Research Scientist and Lab Leader

Genetic Toxicology

Health Canada

Current research and/or projects

Sources, fate and hazards of environmental mutagens and carcinogens.  Applied genetic toxicology for regulatory decision making.

Research and/or project statements

  • Development and evaluation of in vitro tools for mutagenicity assessment
  • Hazard and risk assessment of contaminated sites
  • Hazard and risk assessment of environmental carcinogens in complex mixtures
  • Toxicological hazards of diesel engine emissions
  • Genomic-guided proteomic analyses for biomarker discovery

Professional activities / interests

Member - Ottawa-Carleton Institute of Biology

Member- Ottawa-Carleton Graduate Program in Chemical and Environmental Toxicology

Member - Centre for Advanced Research in Environmental Genomics, University of Ottawa

Editor-in-Chief, Environmental & Molecular Mutagenesis

Education and awards

Excellence in Science Award.  Received from the Deputy Minister of Health, Morris Rosenberg, (2005).

NSERC (Natural Sciences and Engineering Research Council of Canada) Post-doctoral Fellowship.  01/98 - 12/99

Governor General of Canada’s Gold Medal 06/96

Key publications

Jacobsen, NR, White, PA, Gingerich, J., Møller, P., Saber, AT, Vogel, U., H. Wallin. 2010. Mutation spectrum in FE1-Muta™Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environmental & Molecular Mutagenesis.52:331-337.

Bourdon, JA, Bazinet, TM, Arnason, TT, Kimpe, LE, Blais, JM and PA White. 2010. Polychlorinated Biphenyls (PCBs) Contamination and Aryl Hydrocarbon Receptor Activity of Omega-3 Fatty Acid Supplements: Implications for Daily Intake of Dioxins and PCBs. Food & Chemical Toxicology 48:3093-3097.

Lynch, A., Sasaki, JC, Elespuru, R., Jacobson-Kram, D., Thybaud, V., De Boeck, M., Aardema, MJ, Aubrecht, J., Benz, RD, Dertinger, SD, Douglas, GR, White, PA, Escobar, PA, Fornace, A., Honma, M, Naven, RT, Rusling, JF, Schiestl, R, Walmsley, RM, Yamamura, E, van Benthem, J. and JH Kim. 2010. New and emerging technologies for genetic toxicity testing.  Environmental & Molecular Mutagenesis. In press (DOI: 10.1002/em20614).

Chen, G, Gingerich, J, Soper, L, Douglas, GR and PA. White.  2010. Induction of lacZ mutations in Muta™Mouse primary hepatocytes.  Environmental & Molecular Mutagenesis 51:330-337.

Doyle JR, Blais, JM and PA White. 2010. Mass balance soil ingestion estimating methods and their application to inhabitants of rural and wilderness areas: A critical review. Science of the Total Environment 408:2181-2188.

Maertens, RM, White, PA, Rickert, W., Levasseur, G., Douglas, GR, Bellier, PV, McNamee, JP, Thuppal, V., Walker, M., and S. Desjardins. 2009. The Genotoxicity of Mainstream and Sidestream Cannabis and Tobacco Smoke Condensate. Chemical Research in Toxicology. 22:1406-1414.

Jacobsen, NR, Pojana, G., White, PA, Møller, P., Cohn, CA, Korsholm, KS, Vogel, U., Marcomini, A., Loft, S., and H. Wallin. 2008. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C60 fullerenes in the FE1-MutaTMMouse lung epithelial cells. Environmental & Molecular Mutagenesis 49:476-487

Maertens, RM, Yang, X., Zhu, J., Gagné, RW, Douglas, GR, Zhu, J. and PA White. 2008. Mutagenic and Carcinogenic Hazards of Settled House Dust I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure. Environmental Science & Technology 42:1747-1753.

Maertens, RM, Gagné, RW, Douglas, GR, Zhu, J. and PA White.  2008.  Mutagenic and Carcinogenic Hazards of Settled House Dust II: Salmonella Mutagenicity. Environmental Science & Technology 42:1754-1760.

Lemieux, CL, Lambert, IB, Lundstedt, S., Tysklind, M. and PA White.  2008. The mutagenic hazards of complex PAH mixtures in contaminated soil.   Environmental Toxicology & Chemistry 27:978-990.

Expertise

Affiliations

Adjunct Professor, Department of Biology, University of Ottawa