Paul A. White, PhD

Research Scientist and Lab Leader

Genetic Toxicology

Current research and/or projects

Sources, fate and hazards of environmental mutagens and carcinogens. Applied genetic toxicology for regulatory decision making.

Research and/or project statements

Development and evaluation of in vitro tools for mutagenicity assessment
Hazard and risk assessment of contaminated sites
Hazard and risk assessment of environmental carcinogens in complex mixtures
Toxicological hazards of diesel engine emissions
Genomic-guided proteomic analyses for biomarker discovery

Professional activities / interests

Member - Ottawa-Carleton Institute of Biology

Member- Ottawa-Carleton Graduate Program in Chemical and Environmental Toxicology

Member - Centre for Advanced Research in Environmental Genomics, University of Ottawa

Editor-in-Chief, Environmental & Molecular Mutagenesis

Education and awards

Excellence in Science Award. Received from the Deputy Minister of Health, Morris Rosenberg, (2005).

NSERC (Natural Sciences and Engineering Research Council of Canada) Post-doctoral Fellowship. 01/98 - 12/99

Governor General of Canada’s Gold Medal 06/96

Key publications

Jacobsen, NR, White, PA, Gingerich, J., Møller, P., Saber, AT, Vogel, U., H. Wallin. 2010. Mutation spectrum in FE1-Muta™Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environmental & Molecular Mutagenesis.52:331-337.

Bourdon, JA, Bazinet, TM, Arnason, TT, Kimpe, LE, Blais, JM and PA White. 2010. Polychlorinated Biphenyls (PCBs) Contamination and Aryl Hydrocarbon Receptor Activity of Omega-3 Fatty Acid Supplements: Implications for Daily Intake of Dioxins and PCBs. Food & Chemical Toxicology 48:3093-3097.

Lynch, A., Sasaki, JC, Elespuru, R., Jacobson-Kram, D., Thybaud, V., De Boeck, M., Aardema, MJ, Aubrecht, J., Benz, RD, Dertinger, SD, Douglas, GR, White, PA, Escobar, PA, Fornace, A., Honma, M, Naven, RT, Rusling, JF, Schiestl, R, Walmsley, RM, Yamamura, E, van Benthem, J. and JH Kim. 2010. New and emerging technologies for genetic toxicity testing. Environmental & Molecular Mutagenesis. In press (DOI: 10.1002/em20614).

Chen, G, Gingerich, J, Soper, L, Douglas, GR and PA. White. 2010. Induction of lacZ mutations in Muta™Mouse primary hepatocytes. Environmental & Molecular Mutagenesis 51:330-337.

Doyle JR, Blais, JM and PA White. 2010. Mass balance soil ingestion estimating methods and their application to inhabitants of rural and wilderness areas: A critical review. Science of the Total Environment 408:2181-2188.

Maertens, RM, White, PA, Rickert, W., Levasseur, G., Douglas, GR, Bellier, PV, McNamee, JP, Thuppal, V., Walker, M., and S. Desjardins. 2009. The Genotoxicity of Mainstream and Sidestream Cannabis and Tobacco Smoke Condensate. Chemical Research in Toxicology. 22:1406-1414.

Jacobsen, NR, Pojana, G., White, PA, Møller, P., Cohn, CA, Korsholm, KS, Vogel, U., Marcomini, A., Loft, S., and H. Wallin. 2008. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C60 fullerenes in the FE1-MutaTMMouse lung epithelial cells. Environmental & Molecular Mutagenesis 49:476-487

Maertens, RM, Yang, X., Zhu, J., Gagné, RW, Douglas, GR, Zhu, J. and PA White. 2008. Mutagenic and Carcinogenic Hazards of Settled House Dust I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure. Environmental Science & Technology 42:1747-1753.

Maertens, RM, Gagné, RW, Douglas, GR, Zhu, J. and PA White. 2008. Mutagenic and Carcinogenic Hazards of Settled House Dust II: Salmonella Mutagenicity. Environmental Science & Technology 42:1754-1760.

Lemieux, CL, Lambert, IB, Lundstedt, S., Tysklind, M. and PA White. 2008. The mutagenic hazards of complex PAH mixtures in contaminated soil. Environmental Toxicology & Chemistry 27:978-990.