Mylène Blais, Ph.D.

Current research and/or projects

The main objectives related to Dr Blais’s research activities are: 1) To elaborate new strategies to replace the use of antibiotics in the swine industry by improving pig’s immunity and gut health through microbiota optimisation; 2) To develop new technologies and approaches to study swine immune system and gut defenses in response to stress and pathogens; 3) To give a better understanding of swine intestinal and immune development.

Research and/or project statements

  • Early interventions supporting the development of a potent immune system for robust and healthy piglets without the need of AMU using alfalfa silage and cranberry-derived proanthocyanidins applied to the sows and piglets in maternity and nursery.

  • Determine the impact of birth weight and gain weight during lactation on piglets’ immune status, gut development and microbiota.

  • Use of bovine colostrum as a feeding strategy to decrease the use of antibiotics at weaning by improving piglets intestinal defenses and immunity

  • Develop in vitro models of porcine intestinal epithelial cell and immune cell cultures and co-cultures to study intestinal and immune response to enteric pathogens, evaluate the potential of various bioactive products to alleviate inflammation and maintain intestinal epithelial integrity.

  • Evaluate the potential of neonatal fecal transplant to improve piglets’ microbiota diversity, gut development and immunity.

Key publications

  1. Lo Verso L, Matte J, Lapointe J, Talbot G, Bissonnette N, Blais M, Guay F & Lessard M (2020) Impact of birth weight and neonatal nutritional interventions with micronutrients and bovine colostrum on the development of piglet immune response during the peri-weaning period. Vet Immunol Immunopathol 226: 110072
  2. Lessard M, Blais M, Beaudoin F, Deschene K, Lo Verso L, Bissonnette N, Lauzon K & Guay F (2018) Piglet weight gain during the first two weeks of lactation influence the immune system development. Vet Immunol Immunopathol 206:25-34.
  3. Blais M, Fortier M, Pouliot Y, Gauthier SF, Boutin Y, Asselin C & Lessard M (2015) Colostrum whey down-regulates the expression of early and late inflammatory response genes induced by Escherichia coli and Salmonella enterica Typhimurium components in intestinal epithelial cells. Br J Nutr 113:200-211.
  4. Blais M, Pouliot Y, Gauthier S, Boutin Y & Lessard M (2014) A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells. J Nutr Sci 3:e57.

Research facility

2000 College Street
Sherbrooke, QC J1M 1Z3
Canada

Language

English
French

Other languages

Anglais