Lili Mats, Ph.D.

Current research and/or projects

Dr. Mats works in a supporting capacity for many research scientists at GRDC and their collaborators. Modern HPLC-MS instrumentation helps to significantly enhance and accelerate analysis, and allows GRDC scientists to explore emerging fields of proteomics and metabolomics in their research. Her knowledge of metabolomics contributes to the understanding of phytochemical bioavailability, bioaccessibility and health attributes of functional foods and their byproducts. Use of HPLC-MS in characterization and quantification of bioactives in novel functional foods provides more healthy food choices, such as phenolic-rich pulses and anthocyanin-rich grains, to support healthy eating in Canada. Her work in enzymatic and bacterial detoxification helps reduce the risk of harmful food pathogens and promote safety of foods for Canadians. Dr. Mats’ expertise in food quality analysis helps develop new processing technologies and leads to industrial collaborations and partnerships. 

Research and/or project statements

  • Bioactives profiling in agri-food byproducts of pulses and seeds
  • Analysis of phenolics health attributes and molecular mechanisms using metabolomics
  • Characterization and quantification of bioactive compounds (carotenoids and polyphenols) in glabrous canary seed
  • Assessing patulin and deoxynivalenol detoxification through microbial and enzymatic methods
  • Characterization of biochemical and nutritional properties of non-thermally pasteurized milk
  • Assessing effect of UV, temperature, and pressure processing of different juices

Professional activities / interests

  • Method development and optimization for High Performance Liquid Chromatography and Mass Spectrometry (HPLC-MS)
  • Detection, identification and quantification of phytochemicals using HPLC-MS
  • Structure elucidation of novel compounds using MS fragmentation
  • Peptide and proteomics analysis
  • Metabolomic profiling of endogenous and exogenous compounds

Education and awards

Ph.D. Analytical Chemistry, Queen’s University, 2016

B.Sc. (Hons.) Forensic Chemistry, University of Toronto, 2009



  1. Lili Mats, Graham T. T. Gibson, Richard D. Oleschuk. Plastic LC/MS microchip with an embedded microstructured fibre having the dual role of a frit and a nanoelectrospray emitter. Microfluidics and Nanofluidics 2014
  2. Lili Mats, Rachel Young, Graham T. T. Gibson, Richard D.Oleschuk. Magnetic droplet actuation on natural (Colocasia leaf) and fluorinated silica nanoparticle superhydrophobic surfaces. Sensors and Actuators B: Chemical 2015
  3. Lili Mats, Ashley Bramwell, John Dupont, Guojun Liu, Richard Oleschuk. Electrowetting on superhydrophobic natural (Colocasia) and synthetic surfaces based upon fluorinated silica nanoparticles. Microelectronic Engineering 2015
  4. Lili Mats, Fiona Logue, Richard D. Oleschuk.  “Particle-Free” Magnetic Actuation of Droplets on Superhydrophobic Surfaces Using Dissolved Paramagnetic Salts. Analytical Chemistry 2016 https://doi/10.1021/acs.analchem.6b01917
  5. Kyle J. Bachus, Lili Mats, H. W. Choi, Graham T. T. Gibson, Richard D. Oleschuk. Fabrication of Patterned Superhydrophobic/Hydrophilic Substrates by Laser Micromachining for Small Volume Deposition and DropletBased Fluorescence. Applied Materials and Interfaces 2017 https://doi/10.1021/acsami.6b16363

Key publications

  1. Zhong, L., Carere, J., Mats, L., Lu, Z., Lu, F., Zhou, T. (2021). Formation of glutathione patulin conjugates associated with yeast fermentation contributes to patulin reduction. Food Control, [online] 123

    2021 - View publication details

  2. Das, Q., Islam, M.R., Lepp, D., Tang, J., Yin, X., Mats, L., Liu, H., Ross, K., Kennes, Y.M., Yacini, H., Warriner, K., Marcone, M.F., Diarra, M.S. (2020). Gut Microbiota, Blood Metabolites, and Spleen Immunity in Broiler Chickens Fed Berry Pomaces and Phenolic-Enriched Extractives. Frontiers in Veterinary Science, [online] 7

    2020 - View publication details

Research facility

93 Stone Road West
Guelph, ON N1G 5C9


  • Member- American Society for Mass Spectrometry
  • Member- Canadian Forum for Analytical and Bioanalytical Sciences
  • Member- Canadian Society for Mass Spectrometry