Jérôme Lapointe Ph. D.

Research Scientist

My research projects are seeking to improve the health, robustness and longevity of animals in swine production through the development of nutritional strategies geared to controlling oxidative stress and optimizing energy metabolism.

Agriculture and Agri-Food Canada

2000 College Street, Sherbrooke, QC J1M 0C8

Current research and/or projects

Development of genomics tools and management practices to promote animal health, metabolic efficiency, productivity and longevity, reduce their ecological footprint and promote value-added animal products.

Research and/or project statements

- Towards a restricted use of antibiotics and ZnO in pig production: Development of new nutrigenomics approaches based on a better understanding of the interactions between bacterial pathogens, mitochondrial function and zinc levels.

- Innovative micronutrient strategies for maximizing piglet’s robustness and performance during the pre- and post-weaning periods.

- Development of an innovative strategy targeting mitochondria for improving health and resistance of newly weaned piglets, decreasing the needs for antibiotics in swine production and improving food safety.

Professional activities / interests

- Oxidative stress

- Mitochondrial energy metabolism

- Nutrigenomics

- Alternative to antibiotics and heavy metals in swine production

Education and awards

- B. Sc. Biology, Université Laval, 1998.

- Certificate in genetic engeneering, Université Laval, 1998.

- M. Sc. Molecular and cellular biology, Université Laval, 2001.

- Ph. D. physiology-endocrinology, Université Laval, 2005.

- Postdoctorate, Biology, Université McGill, 2011.

International experience and/or work

- Deputy Editor, British Journal of Nutrition, Cambridge University Press.

Key publications

Palin, M.F., Lapointe, J., Gariépy, C., Beaudry, D., Kalbe, C. (2020). Characterisation of intracellular molecular mechanisms modulated by carnosine in porcine myoblasts under basal and oxidative stress conditions. PLoS ONE, [online] 15(9 September), http://dx.doi.org/10.1371/journal.pone.0239496
2020 - View publication details
Palin, M.F., Gariépy, C., Beaudry, D., Lapointe, J. and Kalbe, C. (2019) Protective effects of carnosine on hydrogen peroxide–induced oxidative stress in myoblast cells derived from porcine skeletal muscle. 65th International Congress of Meat Science and Technology 2019 in Potsdam/Berlin, Germany 04– 09 August 2019. (Abstract and Poster)
2019 - View publication details
Palin, M.F., Gariépy, C., Beaudry, D., Lapointe, J. and Kalbe, C. (2018) Carnosine prevents oxidative damage in porcine muscle cells. Canadian Meat Council's 98th Annual Conference, May 29-31, 2018, Montreal, Quebec.
2018 - View publication details
Beaulieu, D., Farmer, C., Brown, J., Lapointe, J. and Palin, M.F. Increasing sow milk yield and piglet growth via low-cost feeding and management strategies during gestation and/or lactation. In Swine Innovation Porc 2017-2018 Final Report. pp. 14-15.
2018 - View publication details
Fortin, É., Blouin, R., Lapointe, J., Petit, H.V., Palin, M.F. (2017). Linoleic acid, α-linolenic acid and enterolactone affect lipid oxidation and expression of lipid metabolism and antioxidant-related genes in hepatic tissue of dairy cows. British Journal of Nutrition, [online] 117(9), 1199-1211. http://dx.doi.org/10.1017/S0007114517000976
2017 - View publication details
Farmer, C., Lapointe, J., Cormier, I. (2017). Providing the plant extract silymarin to lactating sows: Effects on litter performance and oxidative stress in sows. Animal, [online] 11(3), 405-410. http://dx.doi.org/10.1017/S1751731116001919
2017 - View publication details
Talbot, G., Lessard, M., Yergeau, E., Gagnon, N., Lo Verso, L., Lapointe, J., Bissonnette, N., Bueno Dalto, D., Ouattara, B., Guay, F., and Matte, J.J. (2016). "Effects of different sources and routes of administration of copper and vitamins A and D on piglets gut microbiota.", Journal of Animal Science, 94(Supp. 2). (Abstract)
2016 - View publication details
Lo Verso, L., Matte, J.J., Talbot, G., Bissonnette, N., Lapointe, J., Gagnon, N., Ouattara, B., Guay, F., and Lessard, M. (2016). "Effects of different sources and routes of administration of copper and vitamins A and D on gut volatile fatty acids and gene expression involved in regulation of innate and acquired immunity in piglets.", Journal of Animal Science, 94(Supp. 2). (Abstract)
2016 - View publication details
Talbot, G., Lessard, M., Yergeau, E., Gagnon, N., Lo Verso, L., Lapointe, J., Bissonnette, N., Bueno Dalto, D., Ouattara, B., Guay, F., and Matte, J.J. (2016). "Microbiota of the small intestine of piglets affected by perinatal administration of copper and vitamins A and D.", 18th International Conference on Microbiota Buenos Engineering, Buenos Aires, Argentina, 27-28 October, 2016.
2016 - View publication details
Lapointe, J., Roy, C., Beaudry, D., Bergeron, N., Blanchet, I., Petit, H.V., and Palin, M.F. (2016) Effect of flax meal supplementation on oxidative stress and metabolic status of early lactation dairy cows infused with flax oil in the abomasum. Journal of Animal Science Vol. 94, E-Suppl. 5/Journal of Dairy Science Vol. 99, E-Suppl. 1. p. 684. (Abstract 1410) doi:10.2527/jam2016-1410
2016 - View publication details
Lapointe, J., Roy, C.S., Bergeron, N., Lavoie, M., Beaudry, D., Blanchet, I., Petit, H.V., and Palin, M.-F. (2015). "Negative energy balance is associated with inflammatory and oxidative stress conditions in early lactation dairy cows.", Society for Free Radical Biology and Medicine’s (SFRBM) Annual Meeting, Boston, MS, USA, November 18-21, 2015.
2015 - View publication details
Dalto, D.B., Roy, M., Audet, I., Palin, M.F., Guay, F., Lapointe, J., Matte, J.J. (2015). Interaction between vitamin B6 and source of selenium on the response of the selenium-dependent glutathione peroxidase system to oxidative stress induced by oestrus in pubertal pig. Journal of Trace Elements in Medicine and Biology, [online] 32 21-29. http://dx.doi.org/10.1016/j.jtemb.2015.05.002
2015 - View publication details
Lessard, M., Savard, C., Deschene, K., Lauzon, K., Pinilla, V.A., Gagnon, C.A., Lapointe, J., Guay, F., Chorfi, Y. (2015). Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine. Food and Chemical Toxicology, [online] 80 7-16. http://dx.doi.org/10.1016/j.fct.2015.02.013
2015 - View publication details
Morisette, B., Lessard, M.-H., Yergeau, E., Lapointe, J., Guay, F., Bissonnette, N., Matte, J.J., Letellier, A., Quessy, S., Bergeron, N., Beaulieu, C., and Talbot, G. (2014). "Influence of Feed Additives as an Alternative to Antibiotics on Gut Microbiota of Weaned Piglets Infected with Salmonella Typhimurium.", 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts, USA, May 17-20, 2014. (Abstract)
2014 - View publication details
Morisette, B., Lessard, M., Yergeau, E., Lapointe, J., Guay, F., Bissonnette, N., Matte, J.J., Letellier, A., Quessy, S., Bergeron, N., Beaulieu, C., and Talbot, G. (2014). "Influence of Feed Additives as an Alternative to Antibiotics on Gut Microbiota of Weaned Piglets Infected with Salmonella Typhimurium.", 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts, USA, May 17-20, 2014.
2014 - View publication details
Morissette, B., Lessard, M., Yergeau, E., Lapointe, J., Guay, F., Bissonnette, N., Matte, J.J., Letellier, A., Quessy, S., Bergeron, N., and Talbot, B.G. (2014). "Influence of Feed Additives as an Alternative to Antibiotics on Gut Microbiota of Weaned Piglets Infected with Salmonella Typhimurium.", 7ième Symposium du CRIPA, Hyacinthe, Québec, Canada, 3-4 juin 2014. (Poster)
2014 - View publication details
Lessard, M., Deschêne, K., Savard, C., Lapointe, J., Guay, F., and Chorfi, Y. (2014). "Effect of deoxynivalenol (DON) ingestion on expression of genes involved in intestinal integrity and immune response.", 2014 ADSA-ASAS Midwest Meeting, Iowa Events Center, Des Moines, Iowa, USA, March 17-19, 2014, # 163; Oral Présentation. (Abstract)
2014 - View publication details
Lessard, M., Deschêne, K., Savard, C., Gagnon, A.-È., Lapointe, J., Pinilla, V.A., Guay, F., and Chorfi, Y. (2014). "Effect of deoxynivalenol (DON) ingestion on expression of genes involved in intestinal barrier and immune functions.", 7ième Symposium du CRIPA, Hyacinthe, Québec, Canada, 3-4 juin 2014, Présentation orale.
2014 - View publication details
Lapointe, J. (2014). "Mitochondria as promising targets for nutritional interventions aiming to improve performance and longevity of sows.", Journal of Animal Physiology and Animal Nutrition, 98(5), pp. 809-821. doi : 10.1111/jpn.12160
2014 - View publication details
Lapointe, J., Hughes, B.G., Bigras, E., Hekimi, S. (2014). Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism. Physiological Reports, [online] 2(11), http://dx.doi.org/10.14814/phy2.12214
2014 - View publication details