J. David Knox

Image J. David Knox
Chief, Prion Diseases Section

The mission of the section is to contribute to Canada`s ability to detect all cases of Creutzfeldt- Jakob Disease (CJD) and to investigate their origins.

Key publications

Cheng K, Vendramelli R, Sloan A, Waitt B, Podhorodecki L, Godal D, Knox JD : End-point quaking-induced conversion (EP-QuIC): a sensitive, specific, and high-throughput method for the ante-mortem diagnosis of Creutzfeldt-Jacob Disease. J Clin Microbiol, JCM 54(7):1751-1754, 2016.

Godal G, Simon SLR, Cheng K, Knox JD: A new test for Creutzfeldt-Jakob disease: real-time quaking induced conversion. CCDR 41-8:192-195. 2015

Cheng K, Sloan A, Wait B, Vendramelli R, Godal D, Simon S, O'Nei J, Carpenter M,  Jackson D, Eastlake J, Mallinson G, Knox JD: Altered rPrP substrate structures and their influence on real-time quaking induced conversion reactions. Protein Expression and Purification. 143:20-27. 2018.