Guosheng Chen, PhD

Toxicologist

Hazard Methodology Development for Human Health Risk Assessment

Health Canada

Existing Substances Risk Assessment Bureau, Safe Environments Directorate (Ottawa, Ontario)

Current research and/or projects

Application of Molecular Toxicology in Human Health Risk Assessment

Toxicogenomics in regulatory decision-making
Mode of action analysis for carcer risk assessment
Gene expression profiles for chemical characterization
In vitro gene muation assays (i.e. heptaocytes of Muta™Mouse)
Genetic toxicity testing for existing substances with limited data

Professional activities / interests

WHO-IARC Working Group Member for Monograph 95, Indoor air pollution from household heating and cooking: some solid-fuel and cooking-oil fumes. World Health Organization (WHO), International Agency for Research on Cancer (IARC), 10-17 October 2006, Lyon, France

Health Canada Science Forum 2010 Abstract Review Committee member and a Concurrent Session Chair of " in vitro Testing Methods". Ottawa, Canada

Concurrent symposium Chair in SETAC Asia/Pacific Meeting 2006: Mutagenic Hazard in the Environment. Beijing Univesity, Beijing, China

Invited speaker in 9th International Conference on Environmental Mutagens (ICEM), "Mutagenic hazards of aquatic sediments". 2005, San Francisco, California, USA

Manuscript Peer Reviewer for many Scientific Journals - Mutat Res; Environ Mol Mutagen; Chem-Bio Inter; Toxicol Sci; Mutagenesis; Environ Sci Tech; Mol Carcinog; Anal Biochem Chem; Environ Pollution; Environ Res; Int J Environ & Waste Management etc.

Education and awards

NSERC Visiting Fellowship, 2003-2005. Environmental Health Center, Health Canada, Ottawa, Canada

PhD in Biochemistry and Toxicology, 2003. University of Guelph, Guelph, Canada

German BMBF Fellowship, 1996-1997. GSF-Research Center for Environment and Health, Munich, Germany

Key publications

Chen G, Gingerich J, Soper L, Douglas GR and White PA. 2010. Induction of lacZ mutations in Muta™Mouse primary hepatocytes. Environ Mol Mutagen. 51(4): 330-337.

Chen G, White PA, Gingerich J, Soper L and Douglas GR. 2008. Metabolic activation and mutagenicity of 3-nitrobenzanthrone in Muta™Mouse. Environ Mol Mutagen. 49(8): 602-613.

Chen G, Lambert I, Douglas GR and White PA. 2005. Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection. J Chromatogr B, Anal Technol Biomed Life Sci. 824(1-2): 229-237.

Chen G and White PA. 2004. The mutagenic hazards of aquatic sediments: A Review. Mutat Res. 567: 151-225.

Chen G and Bunce NJ. 2004. Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway. Environ Toxicol. 19: 480-489.

Chen G and Bunce NJ. 2003. Polybrominated diphenyl ethers as Ah receptor agonists and antagonists. Toxicol Sci. 76: 310-320.

Chen G, Konstantinov AD, Chittim BG, Heikkila E, Bols NC and Bunce NJ. 2001. Synthesis of Polybrominated Diphenyl Ethers (PBDEs) and their capacity to induce CYP1A by the Ah receptor mediated pathway. Environ Sci Technol 35: 3749-3756.

Petrulis JR, Chen G, Benn S, LaMarre J and Bunce NJ. 2001. Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. Environ Toxicol 16: 177-184.

Chen G, Xu Y, Xu L, Zhang Y, Schramm K-W and Kettrup A. 1998. Influence of Dioxins and metal-contaminated sediments on phase I and phase II biotransformation enzymes in silver crucian carp. Ecotoxicol Environ Safety 40: 234-238.

Chen G, Schramm K-W, Klimm C, Xu Y, Zhang Y and Kettrup A. 1997. Polycyclic Aromatic Hydrocarbons in Ya-Er Lake (Hubei, China): Source and Distribution. Fresenius J of Anal Chem 359: 280-284.