Guosheng Chen, PhD
Hazard Methodology Development for Human Health Risk Assessment
Current research and/or projects
Application of Molecular Toxicology in Human Health Risk Assessment
- Toxicogenomics in regulatory decision-making
- Mode of action analysis for carcer risk assessment
- Gene expression profiles for chemical characterization
- In vitro gene muation assays (i.e. heptaocytes of Muta™Mouse)
- Genetic toxicity testing for existing substances with limited data
Professional activities / interests
WHO-IARC Working Group Member for Monograph 95, Indoor air pollution from household heating and cooking: some solid-fuel and cooking-oil fumes. World Health Organization (WHO), International Agency for Research on Cancer (IARC), 10-17 October 2006, Lyon, France
Health Canada Science Forum 2010 Abstract Review Committee member and a Concurrent Session Chair of " in vitro Testing Methods". Ottawa, Canada
Concurrent symposium Chair in SETAC Asia/Pacific Meeting 2006: Mutagenic Hazard in the Environment. Beijing Univesity, Beijing, China
Invited speaker in 9th International Conference on Environmental Mutagens (ICEM), "Mutagenic hazards of aquatic sediments". 2005, San Francisco, California, USA
Manuscript Peer Reviewer for many Scientific Journals - Mutat Res; Environ Mol Mutagen; Chem-Bio Inter; Toxicol Sci; Mutagenesis; Environ Sci Tech; Mol Carcinog; Anal Biochem Chem; Environ Pollution; Environ Res; Int J Environ & Waste Management etc.
Education and awards
NSERC Visiting Fellowship, 2003-2005. Environmental Health Center, Health Canada, Ottawa, Canada
PhD in Biochemistry and Toxicology, 2003. University of Guelph, Guelph, Canada
German BMBF Fellowship, 1996-1997. GSF-Research Center for Environment and Health, Munich, Germany
Chen G, Gingerich J, Soper L, Douglas GR and White PA. 2010. Induction of lacZ mutations in Muta™Mouse primary hepatocytes. Environ Mol Mutagen. 51(4): 330-337.
Chen G, White PA, Gingerich J, Soper L and Douglas GR. 2008. Metabolic activation and mutagenicity of 3-nitrobenzanthrone in Muta™Mouse. Environ Mol Mutagen. 49(8): 602-613.
Chen G, Lambert I, Douglas GR and White PA. 2005. Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection. J Chromatogr B, Anal Technol Biomed Life Sci. 824(1-2): 229-237.
Chen G and White PA. 2004. The mutagenic hazards of aquatic sediments: A Review. Mutat Res. 567: 151-225.
Chen G and Bunce NJ. 2004. Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway. Environ Toxicol. 19: 480-489.
Chen G and Bunce NJ. 2003. Polybrominated diphenyl ethers as Ah receptor agonists and antagonists. Toxicol Sci. 76: 310-320.
Chen G, Konstantinov AD, Chittim BG, Heikkila E, Bols NC and Bunce NJ. 2001. Synthesis of Polybrominated Diphenyl Ethers (PBDEs) and their capacity to induce CYP1A by the Ah receptor mediated pathway. Environ Sci Technol 35: 3749-3756.
Petrulis JR, Chen G, Benn S, LaMarre J and Bunce NJ. 2001. Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. Environ Toxicol 16: 177-184.
Chen G, Xu Y, Xu L, Zhang Y, Schramm K-W and Kettrup A. 1998. Influence of Dioxins and metal-contaminated sediments on phase I and phase II biotransformation enzymes in silver crucian carp. Ecotoxicol Environ Safety 40: 234-238.
Chen G, Schramm K-W, Klimm C, Xu Y, Zhang Y and Kettrup A. 1997. Polycyclic Aromatic Hydrocarbons in Ya-Er Lake (Hubei, China): Source and Distribution. Fresenius J of Anal Chem 359: 280-284.
Active Full Member of Society of Toxicology (SOT) (2010 - now)
Member of Environmental Mutagens Society (EMS) (2004 - now)
Editorial Board Member for the Elsevier international journal - Mutation Research/Reviews (2007-now)