Guillaume Pelletier

Research Scientist

Toxicology, molecular biology

Health Canada

Current research and/or projects

Assessment of the toxicity of various compounds including flame retardants, plasticizers and plastic additives, using a rat in vivo exposure model. Development of a high-throughput in vitro assay for developmental neurotoxicity testing and of quality control methods for gene expression measurements in rat.

Research and/or project statements

•Assessment of the in vivo toxicity of various compounds in a rat experimental model

•Development of a high-throughput vitro assay for developmental neurotoxicity testing

•Development of quality control methods for gene expression measurements in rat

•Assessment of the effects of air pollution on urinary biomarkers of oxidative stress

•Evaluation of the developmental neurotoxicity of environmental contaminant mixtures

Education and awards

Ph.D. Molecular and cellular biology, Laval University, 2002

B.Sc. Biochemistry, Laval University, 1995       

Key publications

Padhi B.K., Singh M., Rosales M., Pelletier G., Cakmak S. (2018). A PCR-based quantitative assay for the evaluation of mRNA integrity in rat samples. Biomolecular Detection and Quantification, 15, 18-23

 

Pelletier G., Rigden M., Kauri L.M., Shutt R., Mahmud M., Cakmak S., Kumarathasan P., Thomson E., Vincent R., Broad G., Liu L. and Dales R. (2017) Associations between urinary biomarkers of oxidative stress and air pollutants observed in a randomized crossover exposure to steel mill emissions. International Journal of Hygiene and Environmental Health 220:387-394.

 

Padhi B.K., Singh M., Huang N. and Pelletier G. (2016) A PCR-based approach to assess genomic DNA contamination in RNA: Application to rat RNA samples. Analytical Biochemistry 494:49-51.

 

Padhi B.K., Rosales M. and Pelletier G. (2015) Perinatal methylmercury exposure perturbs the expression of Plp1 and Cnp splice variants in cerebellum of rat pups. Neurotoxicology 48:223-230.

 

Pelletier G., Padhi B.K., Hawari J., Sunahara G.I. and Poon R (2015) Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha oil. In Vitro Cellular & Developmental Biology – Animal 51:644-650.

 

Rigden M., Pelletier G., Poon R., Zhu J., Auray-Blais C., Gagnon R., Kubwabo C., Kosarac I., Lalonde K., Cakmak S., Xiao B., Leingartner K., Ku K.L., Bose R. and  Jiao J. (2015) Assessment of Male Rat Liver Function, Serum Chemistry and Urinary Metabolites Following Acute Exposure to Perfluorooctanoic Acid. Arch. Env. Contam. Toxicol. 68(1):148-158.

 

Pelletier G., Valli V.E., Rigden M. and Poon R. (2014) Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazol-3-one biocide formulation in Sprague-Dawley rats.  Drug Chem. Tox. 37(2): 149-155.

 

Poon R., Valli V.E., Ratnayake W.M., Rigden M., and Pelletier, G. (2013). Effects of Jatropha oil on rats following 28-day oral treatment. J. Appl. Toxicol. 33(7): 618-625.

 

Padhi B.K. and Pelletier G. (2012) Perturbation of Myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury. Tox. Lett. 213(3):374-80.

 

Poon R., Valli V.E., Rigden M., Rideout G. and Pelletier G. (2009) Four-Week Oral Toxicity Study of Three Biodiesels and an Ultra-Low Sulfur Diesel. Food Chem. Tox. 47(7): 1416-24.

 

Pelletier G., Masson S., Wade M.J., Nakai J., Alwis R., Mohottalage S., Kumarathasan P., Black P., Bowers W.J., Chu I. and Vincent R. (2009) Contribution of methylmercury, polychlorinated biphenyls and organochlorine pesticides to the toxicity of a mixture based on the blood contaminant profile of Canadian Arctic populations. Tox. Lett. 184(3):176-85.

                                                           

Padhi B.K., Pelletier G., Williams A., Berndt-Weis L., Yauk C., Bowers W.J. and Chu I. (2008) Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Tox. Lett. 176(2):93-103.