Frank You

Image Frank You
Research Scientist

Research in genomics and bioinformatics of crops, especially wheat and flax. Primarily working on plant bioinformatics, quantitative genetics and statistical genomics, genome sequencing, genome evolution, and software tool and database development

Current research and/or projects

  • Genetic and epigenetic variants of Canadian cereal crops for breeding and functional analysis; GRDI project.

  • Integrated genomics, plant pathology and breeding research for improvement of Fusarium Head Blight resistance in Canadian cereals; WGRF project.

  • Characterization of rust resistance genes of flax; ADF project.

  • Early-maturing dry bean variety and germplasm development for Manitoba and Western Canada; CAP pulse cluster.

  • Pre-breeding platform for Canadian wheat improvement; CAP wheat cluster.

  • Genomics and molecular markers to identify resistance genes in flax; CAP project.

  • 4DWheat: diversity, domestication, discovery and delivery; Genome Canada and AAFC project.

  • Targeted and useful genomics for barley and oat; AAFC project.

 

Research and/or project statements

  • Development of a new generation of flax refeence genome.
  • QTL identification and gene mining for the traits of inportance, especially seed yield and disease resistance in flax and wheat.
  • Development of a genomic selection strategy to maximize prediction accuracy and reducing selection cost through minimizing the number of markers.
  • Development of bioinfomatics tools amd databases to facilitate analysis of a large amount of genomic and phenotypic data and gene mining.

Education and awards

  • Ph.D. Plant Genetics and Breeding (Statistical Genetics), Nanjing Agricultural University, 1989
  • MSc Plant Genetics and Breeding (Statistical Genetics), Nanjing Agricultural University, 1985
  • BSc Computer Science, University of Manitoba, 1999
  • BSc Agronomy, Sichuan Agricultural University, 1982

Key publications

  1. Cloutier S, Fedak G, Fatima F, Bartaula S, McCallum B, Henriquez MA, Blackwell B, Aboukhaddour R, Foster A, Hiebert C, Humphreys G, Mccartney C, Pozniak C, You F (2022) Wheat Pre-breeding: the struggle(s) and potential. Proc. 37th Plant Sciences Graduate Students’ Symposium 2022, March 4-5, Virtual (oral)

    2022 - View publication details

  2. Cloutier S, Fedak G, Fatima F, Bartaula S, McCallum B, Henriquez MA, Blackwell B, Aboukhaddour R, Foster A, Hiebert C, Humphreys G, McCartney C, Pozniak C, You F (2021) The challenges and promises of pre-breeding. Can Soc Plant Biol – Eastern Regional Meeting. Virtual, Nov 27 (oral keynote plenary)

    2021 - View publication details

  3. Suo, R.Z., Mwaniki, A., Zheng, C.F., Jia, B., You, F.M., Conner, R.L., Xu, W.1 and Hou, A. QTL identification of seed hardness traits in a diverse genetic panel of common bean (Phaseolus vulgaris). Poster presentation. Bean Improvement Cooperative Biennial Meeting (Virtual), November 2-3, 2021.

    2021 - View publication details

  4. Wayne Xu, James R Tucker, Wubishet A Bekele, Frank M You, Yong-Bi Fu, Raja Khanal, Zhen Yao, Jaswinder Singh, Brian Boyle, Aaron D Beattie, François Belzile, Martin Mascher, Nicholas A Tinker, Ana Badea, Genome Assembly of the Canadian Two-row Malting Barley Cultivar AAC Synergy, G3 Genes|Genomes|Genetics, 2021;, jkab031, https://doi.org/10.1093/g3journal/jkab031

    2021 - View publication details

  5. Sertse, D., You, F.M., Ravichandran, S., Soto-Cerda, B.J., Duguid, S., Cloutier, S. (2021). Loci harboring genes with important role in drought and related abiotic stress responses in flax revealed by multiple GWAS models. Theoretical and Applied Genetics (TAG), [online] 134(1), 191-212. http://dx.doi.org/10.1007/s00122-020-03691-0

    2021 - View publication details

  6. Khan, N., You, F.M., Datla, R., Ravichandran, S., Jia, B., Cloutier, S. (2020). Genome-wide identification of ATP binding cassette (ABC) transporter and heavy metal associated (HMA) gene families in flax (Linum usitatissimum L.). BMC Genomics, [online] 21(1), http://dx.doi.org/10.1186/s12864-020-07121-9

    2020 - View publication details

  7. Fatima F, McCallum BD, Pozniak CJ, Hiebert C, McCartney C, Fedak G, You FM, Cloutier S* (2020) Resistance gene cloning from a wild crop relative by sequence capture and association genetics. Frontiers Plant Sci 11:583738 (doi: 10.3389/fpls.2020.583738)

    2020 - View publication details

  8. Yao, Z., You, F.M., N'Diaye, A., Knox, R.E., McCartney, C., Hiebert, C.W., Pozniak, C., Xu, W. (2020). Evaluation of variant calling tools for large plant genome re-sequencing. BMC Bioinformatics, [online] 21(1), http://dx.doi.org/10.1186/s12859-020-03704-1

    2020 - View publication details

  9. Lan, S., Zheng, C., Hauck, K., McCausland, M., Duguid, S.D., Booker, H.M., Cloutier, S., You, F.M. (2020). Genomic prediction accuracy of seven breeding selection traits improved by QTL identification in flax. International Journal of Molecular Sciences, [online] 21(5), http://dx.doi.org/10.3390/ijms21051577

    2020 - View publication details

  10. Fatima F, McCallum B, Hiebert C, McCartney C, Fedak G, Pozniak C, Edwards T, Ravichandran S, You FM, Cloutier S (2020) Single and multi-locus genome-wide association study for leaf rust resistance in cultivated, progenitor and wild wheat. Proc 28th Plant and Animal Genome Conference, San Diego, USA, Jan 11-15, PO0937

    2020 - View publication details

  11. Cloutier S, You F, Rashid K, Zheng C, Lam S, Khan N, He L, Xiao X, Yao J, Li P (2020) Insights into genetic structure and genomic prediction of powdery mildew resistance in flax (Linum usitatissimum L.). Proc 28th Plant and Animal Genome Conference, San Diego, USA, Jan 11-15, PO0499

    2020 - View publication details

  12. Soto-Cerda, B.J., Cloutier, S., Gajardo, H.A., Aravena, G., Quian, R., You, F.M. (2020). Drought response of flax accessions and identification of quantitative trait nucleotides (QTNs) governing agronomic and root traits by genome-wide association analysis. Molecular Breeding, [online] 40(1), http://dx.doi.org/10.1007/s11032-019-1096-y

    2020 - View publication details

  13. Sertse, D., You, F.M., Ravichandran, S., Cloutier, S. (2019). The Complex Genetic Architecture of Early Root and Shoot Traits in Flax Revealed by Genome-Wide Association Analyses. Frontiers in Plant Science, [online] 10 http://dx.doi.org/10.3389/fpls.2019.01483

    2019 - View publication details

  14. Cloutier S, You FM, Soto-Cerda BJ (2019) Linum Genetic Markers, Maps and QTL Discovery. In: Genetics and Genomics of Linum, Plant Genetics and Genomics: Crops and Models 23, Cullis CA (ed), Springer Nature, Switzerland, Chap 7, doi.org/10.1007/978-3-030-23964-0_7

    2019 - View publication details

  15. You FM, Cloutier S (2019) Assembly of the Flax Genome into Chromosomes. In: Genetics and Genomics of Linum, Plant Genetics and Genomics: Crops and Models 23, Cullis CA (ed), Springer Nature, Switzerland, Chap 5, doi.org/10.1007/978-3-030-23964-0_5

    2019 - View publication details

  16. Sertse, D., You, F.M., Ravichandran, S., Cloutier, S. (2019). The genetic structure of flax illustrates environmental and anthropogenic selections that gave rise to its eco-geographical adaptation. Molecular Phylogenetics and Evolution, [online] 137 22-32. http://dx.doi.org/10.1016/j.ympev.2019.04.010

    2019 - View publication details

  17. Fatima F, Edwards T, Hiebert C, McCartney C, McCallum B, Henriquez MA, Humphreys G, Cao W, Fedak G, You FM, Cloutier S (2019) Diversity analysis of wheat and wild relatives using the wheat 90K Infinium array. Proc 1st International Wheat Congress, Saskatoon, July 21-27, P217 (poster)

    2019 - View publication details

  18. Young LW, Trouve J-P, Speck A, Kutcher R, Rashid KY, You FM, Cloutier S and Booker HM. Mapping rust and powdery mildew resistant genes in flax. XXVII Plant and Animal Genome Conference, San Diego, USA, January 12-16, 2019 (PO0871).

    2019 - View publication details

  19. Jia G, You FM, Cloutier S, Deyholos MK, and Booker H. The flax breeding database (FlaxDB). XXVII Plant and Animal Genome Conference, San Diego, USA, January 12-16, 2019. PE1082

    2019 - View publication details

  20. Bruskiewich RM, Caron CT, Kucheran LS, Jia G, Young LW, Staton SE, Légaré J-S, Wang Z, Huellas-Bruskiewicz K, Warfield A, Marden E, Bett K, Booker HM, Cloutier S, You FM and Rieseberg LH. The DivSeek Canada Initiative: out of the starting gate. XXVII Plant and Animal Genome Conference, San Diego, USA, January 12-16, 2019 (PO0035)

    2019 - View publication details

Research facility

960 Carling Avenue
Ottawa, ON K1A 0C6
Canada

Affiliations

Guest professor of Nanjing Agricultural University

Adjunct professor of University of Manitoba

Language

English

Other languages

Mandarin/Chinese