François Gagné

Research Scientist - Molecular Ecotoxicology Specialist

Initiate, develop and execute research projects in aquatic ecotoxicology especially in method development in molecular ecotoxicology.

Environment and Climate Change Canada

Current research and/or projects

Contribution to the protection and conservation of aquatic ecosystems

Molecular ecotoxicology of aquatic contaminants; development of biomarkers/bioassays to measure the cumulative effects of emerging substances (pharmaceuticals, rare earth elements and nanotoxicology) in aquatic ecosystems
Ecotoxicity evaluation of complex mixtures such as municipal effluents and industrial (oil sands) effluents.
Cumulative effects of global warming in freshwater mussels and fish
Development of environmantal DNA approaches for the presence of transgenic organisms (BT-corn) and cyanobacteria.
Study of the quality of the Saint-Lawrence estuary (Tadoussac sector) by determining various biochemical and physiological effects in soft-shell clams with the partnership of Parks Canada.
Non-linear modelling of biological effects using wave theory. Impacts of pollution on periodic rythms in aquatic organisms.

Professional activities / interests

Ecotoxicology, neuroendocrine disruption in mussels and fish caused by urban discharges

Aquatic nanotoxicology

Environmental impacts of products of biotechnology

Interaction of climate warming on ecotoxicological impacts of contaminants

Education and awards

Award of merit for the best scientific presentation at an international symposium (International Symposium on Toxicity Assessment)

Award for the best presentation for research on alternatives in aquatic toxicology (1st World Congress on Alternatives)

International experience and/or work

Produced a book of methods in Biochemical Ecotoxicology (www.store.elsevier.com/9780124116047)

Chief Editor, Journal of Xenobiotics : http://www.pagepressjournals.org/index.php/xeno

Additional links

Chief Editor, Journal of Xenobiotics : http://www.pagepressjournals.org/index.php/xeno

Biochemical Ecotoxicology book: www.store.elsevier.com/9780124116047

Key publications

1) Gagné F, Auclair J, Trépanier S, Turcotte P, Pilote M, Gagnon C. 2016. The impact of zinc oxide nanoparticles in freshwater mussels exposed to municipal effluents. Invert Surv J. 13, 281-290.

2) Gagné, F, Fortier M, Fournier M, Gagnon C. 2016. Immunotoxicity of Zinc Oxide Nanoparticles and Municipal Effluents to Fathead Minnows. Toxicol Open Access 2:2-11.

3) Gagné, F., 2016. The wave nature of molecular responses in ecotoxicology. Current Topics Toxicol, 12, 11-24.

4) Gagné, F.,Bruneau, A., Turcotte, P., Gagnon, C., Lacaze, E. 2016. An investigation of the immunotoxicity of oil sands processed water and leachates in trout leucocytes. Ecotoxicol Environ Saf., 141, 43-51.

5) Gagné, F., André, C.,Turcotte, P., Gagnon, C., Sherry, J .2016. Comparative toxicogenomics of selected naphthenic acids, oil sand lixivates and processed water in rainbow trout hepatocytes. SOJ Biochemistry 2, 13-25.

6) Gagné, F., Trépanier, S., André, C., 2016. Neurotoxicological effects of municipal effluents in fathead minnow Pimephale promelas. Environ Poll Prot 1, 1-11.

7) Pilote M., André C., Turcotte P., Gagné F., Gagnon C.2016. Metal bioaccumulation and effects biomarkers mussels caged in the Athabasca Oil Sands mining area. STOTEN 610-611, 377-390.

8) Houda, H., André. C., Turcotte, P., Gagnon, C., Gagné, F. 2016. Effects of lanthanum in Zebra mussels. SOJ Biochemistry 3, 8-15.

9) Houda, H., André. C., Turcotte, P., Gagnon, C., Gagné, F. 2016. Comparative toxicity of ionic and medical gadolinium in zebra mussels. Chemosphere 181, 197-207.

10) Auclair, J., Wilkinson, K.J., Gagné, F. 2017. Sublethal effects of poly (amidoamine) dendrimers in rainbow trout hepatocytes

SOJ Biochemistry 2, 6-11.

11) Auclair, J., Wilkinson, K.J., Gagné, F. 2017. Synergistic Toxicity of PAMAM Dendrimers and Minocycline to Rainbow Trout Hepatocytes. EC Pharmacologyand Toxicology 3, 138-145.

12) Mermana, J., Sutthiviyakit, P., Blaise, C., Gagné, F., Charnsethikul, S., Kidkhunthod, P., Sutthivaiyakit, S. 2016. Photocatalysis of S-metholachlor in aqueous suspension of magnetic cerium-doped mTiO2 core-shell under stimulation of solar light. Environ Sci Pollut Res DOI 10.1007”s11356-016-8151-6.

13) Bruneau A, Turcotte P, Pilote M, Gagné F, Gagnon C 2015. Fate and Immunotoxic Effects of Silver Nanoparticles on Rainbow Trout in Natural Waters. J Nanomed Nanotechnol 6: 1000290.

14) Gagné F.,Trépanier S., André C., Gagnon C. 2015. Hepatic and reproductive toxicity of a physico-chemically treated municipal effluent to fathead minnows. Current Topics in Toxicology 11, 1-13.

15) Gagné F. André C. 2017. Fourier Transformation Analysis of Stress Biomarkers in Mussels Exposed to Lethal Municipal Effluents. Biomark Applic 102, 1-8.