Dr. Thomas Netticadan

Image Thomas Netticadan
Research Scientist

Investigate the cardiovascular benefits of Canadian food crops

Agriculture and Agri-Food Canada
Canadian Centre for Agri-Food in Health and Medicine, Winnipeg

Current research and/or projects

Overall research goal 

To examine the potential of foods, food-derived extracts and purified components in preventing the development of obesity/diabetes, hypertension and heart failure by utilizing cell culture models and animal models.

 

Projects

Potential of oat derived compounds in preventing the development of hypertension and heart disease in the spontaneously hypertensive rat.

Potential of whole flaxseed and flaxseed derived fractions in preventing the development of heart disease in rats subjected to coronary artery occlusion.

Potential of edible oils in preventing the development of obesity and heart disease in the high fat-fed rat.

Potential of polyphenols in preventing the development of ischemic heart disease in rats subjected to coronary artery ligation.

Potential of fatty acids and polyphenols in preventing cardiomyocyte (heart muscle cell) death and dysfunction.

Education and awards

PhD, University of Bombay, India

Postdoctoral studies, Institut National de la Santé et de la  Recherche Médicale, France.

Postdoctoral studies, University of Western Ontario, Canada.

Key publications

  1. C. Kodikara, N. Bandara, T. Netticadan, S. Sura, C. Wijekoon (2023 March 30). Bioactive profiling of Prairie Berries. The American Chemical Society Spring Meeting (ACS Spring) March 2023

    2023 - View publication details

  2. C. Kodikara, S. Sura, N. Bandara, T. Netticadan, C. Wijekoon (2023 Jan 19-20) Metabolomics assisted investigation of bioactive compounds in prairie berries. Rapid fire symposium at CCARM. Winnipeg

    2023 - View publication details

  3. Ibrahim, N.H.M., Thandapilly, S.J., Jia, Y., Netticadan, T., Aukema, H. (2016). Soy Protein Alleviates Hypertension and Fish Oil Improves Diastolic Heart Function in the Han:SPRD-Cy Rat Model of Cystic Kidney Disease. Lipids, [online] 51(5), 635-642. http://dx.doi.org/10.1007/s11745-015-4095-8

    2016 - View publication details

  4. Raj, P., Zieroth, S., and Netticadan, T. (2015). "An overview of the efficacy of resveratrol in the management of ischemic heart disease.", Annals of the New York Academy of Sciences, 1348(1), pp. 55-67. doi : 10.1111/nyas.12828

    2015 - View publication details

  5. Raj, P., Lieben Louis, X., Thandapilly, S.J., Movahed, A., Zieroth, S., and Netticadan, T. (2014). "Potential of resveratrol in the treatment of heart failure.", Life Sciences, 95(2), pp. 63-71. doi : 10.1016/j.lfs.2013.12.011

    2014 - View publication details

  6. Louis, X.L., Thandapilly, S.J., Kalt, W., Vinqvist-Tymchuk, M., Aloud, B.M., Raj, P., Yu, L., Le, H., Netticadan, T. (2014). Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress, 5(8), 1785-1794. http://dx.doi.org/10.1039/c3fo60588d

    2014 - View publication details

  7. Brown, D.C.W., McCallum, J.L., Siow, Y.L., Jordan, M.C., Netticadan, T., Kirby, C.W., and Ross, K.A. (2013). The Characterization and Proof of Efficacy of Bioactives from Fruits. Project ID: 1717; Research Project Final Report 2012-2013., AAFC Science and Technology Branch. (Report)

    2013 - View publication details

  8. Movahed, A., Nabipour, I., Lieben Louis, X., Thandapilly, S.J., Yu, L., Kalantarhormozi, M., Rekabpour, S.J., Netticadan, T. (2013). Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients, 2013 http://dx.doi.org/10.1155/2013/851267

    2013 - View publication details

  9. Thandapilly, S.J., Louis, X.L., Yu, L., Vinqvist-Tymchuk, M.R., Kalt, W., and Netticadan, T. (2012). "Blueberry fractions prevent norepinephrine induced cardiomyocyte hypertrophy and cell death.", 10th International Symposium on Vaccinium and Other Superfruits, Maastricht, Limburg, The Netherlands, June 17-22, 2012.

    2012 - View publication details

  10. Brown, D.C.W., McCallum, J.L., Siow, Y.L., Jordan, M.C., Netticadan, T., Kirby, C.W., and Ross, K.A. (2012). The Characterization and Proof of Efficacy of Bioactives from Fruits. Project ID: 1717; Research Project Annual Report 2011-2012., AAFC Science and Technology Branch. (Report)

    2012 - View publication details

  11. Movahed, A., Yu, L., Thandapilly, S.J., Louis, X.L., and Netticadan, T. (2012). "Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury.", Archives of Biochemistry and Biophysics, 527(2), pp. 74-80. doi : 10.1016/j.abb.2012.05.002

    2012 - View publication details

  12. Louis, X.L., Murphy, R., Thandapilly, S.J., Yu, L., Netticadan, T. (2012). Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: A role for nitric oxide and hydrogen sulfide, 12 http://dx.doi.org/10.1186/1472-6882-12-140

    2012 - View publication details

  13. Brown, D.C.W., Mazza, G., Ross, K.A., Jordan, M.A., McCallum, J.L., Netticadan, T., Siow, Y.L., Khanizadeh, S., Ames, N.P., and Lui, E.M.K. (2011). "Plant Bioactives Research in Canada.", Plant Bioactives Research in Canada. Canada-United Kingdom Gut and Health Workshop, AAFC-FRDC / AAC-CRDA, Saint-Hyacinthe, QC, Canada, February 24-25, 2011. (Poster)

    2011 - View publication details

  14. Brown, D.C.W., Mazza, G., Ross, K.A., Jordan, M.A., McCallum, J.L., Netticadan, T., Siow, Y.L., Khanizadeh, S., Ames, N.P., and Lui, E.M.K. (2011). "Plant Bioactives Research in Canada.", Plant Bioactives Research in Canada. Canada-United Kingdom Gut and Health Workshop, AAFC-FRDC / AAC-CRDA, Saint-Hyacinthe, QC, Canada, February 24-25, 2011.

    2011 - View publication details

  15. Thandapilly, S.J., Louis, X.L., Yang, T., Stringer, D.M., Yu, L., Zhang, S., Wigle, J., Kardami, E., Zahradka, P., Taylor, C., Anderson, H.D., Netticadan, T. (2011). Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway. European Journal of Pharmacology, [online] 668(1-2), 217-224. http://dx.doi.org/10.1016/j.ejphar.2011.06.042

    2011 - View publication details

  16. Santiago, J.-J., Ma, X., McNaughton, L.J., Nickel, B.E., Bestvater, B.P., Yu, L., Fandrich, R.R., Netticadan, T., and Kardami, E. (2011). "Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes.", Cardiovascular Research, 89(1), pp. 139-147. doi : 10.1093/cvr/cvq261

    2011 - View publication details

  17. Wojciechowski, P., Louis, X.L., Thandapilly, S.J., Yu, L., and Netticadan, T. (2010). "Potential of Resveratrol in Preventing the Development of Heart Failure.", Current Chemical Biology, 4(1), pp. 84-88.

    2010 - View publication details

  18. Behbahani, J., Thandapilly, S.J., Louis, X.L., Huang, Y., Shao, Z., Kopilas, M.A., Wojciechowski, P., Netticadan, T., and Anderson, H.D. (2010). "Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat.", American Journal of Hypertension, 23(12), pp. 1273-1278. doi : 10.1038/ajh.2010.161

    2010 - View publication details

  19. Wojciechowski, P., Juric, D., Louis, X.L., Thandapilly, S.J., Yu, L., Taylor, C.G., and Netticadan, T. (2010). "Resveratrol Arrests and Regresses the Development of Pressure Overload- but Not Volume Overload-Induced Cardiac Hypertrophy in Rats.", Journal of Nutrition, 140(5), pp. 962-968. doi : 10.3945/jn.109.115006

    2010 - View publication details

  20. Juric, D., Yao, X.-H., Thandapilly, S.J., Louis, X.L., Cantor, E.J.F., Chaze, B., Wojciechowski, P., Vasanji, Z., Yang, T., Wigle, J., and Netticadan, T. (2010). "Defects in ryanodine receptor are associated with systolic dysfunction in rats subjected to volume overload.", Experimental Physiology, 95(8), pp. 869-879. doi : 10.1113/expphysiol.2009.052100

    2010 - View publication details

Contact

Research facility

Morden Research and Development Centre
Route 100, Unit 100-101
Morden, MB R6M 1Y5
Canada

Expertise

Food›Nutrition›Health Benefits

Affiliations

Adjunct Professor, Department of Physiology and Pathophysiology, University of Manitoba

Language

English