Dr. Shiliang Liu

Image Shiliang Liu
Senior Research Scientist

Applied Research Division & Maternal, Child and Youth Health Division, Centre for Surveillance and Applied Research

Current research and/or projects

Dr. Liu’s primary research interests are perinatal epidemiology, maternal and child health, specifically, fetal and early childhood development. He also focuses on promoting perinatal health and preventing congenital anomalies through research and surveillance activities. His lab produces new evidence in support of core public health priorities.

Research and/or project statements

  • Assessing the impact of COVID-19 pandemic on maternal and child health, and the burden on the health care system

  • Advancing the Government's efforts to carry out maternal mortality and severe maternal morbidity surveillance with innovate approaches

  • Quantify the associations between maternal characteristics, conditions and prenatal factors and serious congenital anomalies in the offspring

  • Elucidate the paradox in perinatology through demonstrating the heterogeneity of, and prevent preterm and low birthweight infants

  • Assess the association of perinatal maternal depression and anxiety with early neurodevelopment abnormality

  • Evaluate the INTERGROWTH-21st Project fetal and newborn standard for use in Canada

Professional activities / interests

Supervises graduate students and young professionals

Invited to seminars in Canada and internationally

Peer review for Canada Research Chairs (CRC) Program and Canadian Institutes of Health Research (CIHR) funding and training programs

Education and awards


Certificate, Reproductive & Perinatal Epidemiology, University of Michigan, USA, 2005

Postdoctoral fellow, Chronic Disease Epidemiology, NSERC fellowship, Health Canada, 1996-1998

DipPH, Chronic Disease Prevention & Control, National Institutes of Health, USA, 1996

PhD, Epidemiology, Tongji Medical University, China, 1993

MSc, Health Statistics, Tongji Medical University, China, 1988

MB (Doctor of Medicine equivalent), Hengyang Medical College, China, 1983


CIHR grant of $100,000 for a project aimed at adapting new international fetal and newborn growth standards (Intergrowth-21st Project) for use in Canada {2017-2020}

CIHR grant of 1,150,000 for a project aimed at enhancing Canadian perinatal care regionalization through systems approach (with a team of researchers across Canada) {2017-2022}

International experience and/or work

International panels on universal food fortification intervention and the public health policy, and Healthy Mothers and Healthy Babies.

Teach neonatologists at the International Training Program in Neonatal-Perinatal Medicine

Advisor to the Director of the WHO-Shanghai Collaborative Centre for Statistics on Maternal and Child Health, Shanghai, China

Guest Professor, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China

Key publications

Liu, S., Hughes, C., Yong, S.J., Chen, D., Association of maternal depression and hypothyroidism with infant gastroschisis: A population-based cohort study in Canada. Scientific Reports 2023 https://doi.org/10.21203/rs.3.rs-2553794/v1.

Yong, S.J., Liu, S. Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies. Reviews in Medical Virology 2022. doi: 10.1002/rmv.2315.

Wei, S. Q., Bilodeau-Bertrand, M., Liu S., Auger, N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ 2021 April 19;193:E540-8. doi:  10.1503/cmaj.202604

Boutin, A., Lisonkova, S., Muraca, G., Razaz, N., Liu, S., Kramer M.S, Joseph, K. S., Bias in comparisons of mortality among very preterm births. PloS ONE, 2021 https://doi.org/10.1371/journal.pone.0253931


Liu, S., Evans, J., Boutin, A., Luo, W., Gheorghe, M., Auger, N., Laura, A., Moore, A., Joseph, K.S., Little, J., Time trends, geographic variation and risk factors for gastroschisis in Canada, 2006 to 2017. Paediatr Perinat Epidemiol. 2021; 35(6): 664-73.DOI: 10.1111/ppe.12800.

Liu, S., Dzakpasu, S., Nelson, C., Wei, SQ., Little, J., Scott H., Joseph, KS. Pregnancy outcomes during the COVID-19 pandemic in Canada, March to August 2020. J Obstet Gynaecol Can 2021;12:1406-15. https://doi.org/10.1016/j.jogc.2021.06.014


Yong, S.Y., Liu, S. Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies. Rev Med Virol. 2021; e2315: https: doi:10.1002/rmv.2315

Bakker, MK., Bergman, JEH., Krikov, S., Amar, E., Cocchi, G., Cragan, J., de Walle, HEK., Gatt, M., Groisman. B., Liu S, et al. Prenatal diagnosis and prevalence of critical congenital heart defects: An international retrospective cohort study BMJ Open 9:e028139.http://doi.org/10.1136/bmjopen-2018-028139

Dzakpasu S, Deb-Rinker P, Arbour L, Darling EK, Kramer MS, Liu S, et al. Severe maternal morbidity in Canada: Temporal trends and regional variations, 2003-2016. J Obstet Gynaecol Can. 2019 May 3. pii: S1701-2163(19)30089-1.http://doi.org/10.1016/j.jogc.2019.02.014

Muraca, G.M, Liu, S, Sabr, Y., Lisonkova, S., Skoll, A., Brant, R, Cundiff, G.W., Stephansson. O., Razaz, N., Joseph, K.S. Episiotomy use among vaginal deliveries and the association with anal sphincter injury: a population-based retrospective cohort study. CMAJ 2019; October 21, 191:E1149-58. http://doi.org/10.1503/cmaj.190366

Liu, S., Pan, Y., Auger, N., Sun, W., Li, S., Xie, S., Wen, S.W., Chen, D.J. Small head circumference at birth: a multiyear liveborn cohort study in China. BMJ Paediatrics Open 3:e000470. http://doi.org/10.1136/bmjpo-2019-000470

Dzakpasu S, Deb-Rinker P, Arbour L, Darling EK, Kramer MS, Liu S, et al. Severe maternal morbidity surveillance: Monitoring pregnant women at high risk for prolonged hospitalisation and death. Paediatr Perinat Epidemiol 2019; http://doi.org/10.1111/ppe.12574

Liu, S., Evans J., MacFarlane, A., Ananth CV., Little J., Kramer MS., Joseph KS. Association of maternal risk factors with the recent rise of neural tube defects in Canada. Pediatri and Perinat Epidemiol 2019; http://doi.org/10.1111/PPE.12543

Liu S, Chan WS, Ray JG, Kramer MS, Joseph KS. Stroke and cerebrovascular disease in pregnancy: incidence, temporal trends, and risk factors. Stroke 2018;50:13-20.

Li, D., Chen, Y., Sun W., Liu, S. Association between hypertensive disorders during pregnancy and the subsequent risk of end-stage renal disease: a population-based follow-up study.  J Obstet Gynaecol Can 2018;40(9): 1129-1137. https://doi.org/10.1016/j.jogc.2018.01.022

Research facility

1015 Arlington Street
Winnipeg, MB R3E 3M4


Adjunct Professor, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa

Adjunct Professor, Faculty of Graduate Studies and Postdoctoral Research, University of Ottawa

Adjunct Professor, Maternal-Fetal Medicine, Research Institute of Obstetrics & Gynecology, Third Affiliated Hospital, GuangZhou Medical University, GuangZhou, China



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