Dr. Mike Wade, PhD
Current research and/or projects
Environmental influences on reproduction, development of the male reproductive tract, spermatogenesis, sperm maturation and function
Developmental effects of thyroid hormone toxicity
Testing Methodologies for detection of endocrine disrupting substances
Research and/or project statements
- Molecular basis of toxicity to germ cells and steroid hormone production.
- Development and validation of rapid in vivo methods to identify thyroid disrupting substances.
Professional activities / interests
Member of the Advisory Group on Endocrine Disrupters Testing & Assessment, Test Guidelines Program of the Organization of Economic Cooperation & Development.
Leader, Reproductive & Developmental Toxicology Laboratory, Hazard Identification Division
Education and awards
PhD, Reproductive Physiology, University of Guelph
Bowers, W.J., Wall P., Nakai, J.S., Yagminas, A., Wade, M., Li, N. and Chu, I. Behavioural and thyroid effects of in utero and lactational exposure of Sprague Dawley rats to the polybrominated diphenyl ethers mixture DE71. Neurotoxicol & Teratol. (in press)
Dong H, You S-H, Williams A, Wade MG, Yauk CL, Zoeller RT. Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study. Cereb Cortex (in press. PMID: 24436321)
Hongyan Dong, Santokh Gill, Ivan H. Curran, Andrew Williams, Byron Kuo, Michael G. Wade & Carole L. Yauk. Toxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats. Archives of Toxicology (doi:10.1007/s00204-015-1561-2)
Atlas E, Pope L, Wade MG, Kawata A, Boudreau A, Boucher JG. Bisphenol A increases aP2 expression in 3T3L1 by enhancing the transcriptional activity of nuclear receptors at the promoter. Adipocyte. 2014 Jul 1;3(3):170-9)
Shirley Poon, David Pirrello, Michael Wade, Katarina Aleksa, Thea Rawn, Amanda Carnevale , Sheila Ernest, Claudia Lalanchette, Gideon. Koren, Barbara Hales, Bernard Robaire. Utility of hair as a biomarker of matrix to assess systemic deposition to of polybrominated diphenyl ethers (PBDEs) in a rat model. Environ Sci Technol. 48:14650-14658.
Robert G. Berger, Pavine L.C. Lefèvre, Sheila R. Ernest, Michael G. Wade, Yi-Qian Ma, Dorothea Rawn, Dean Gaertner, Bernard Robaire, Barbara F. Hales., Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants affects Fetal Development in Sprague-Dawley Rats Toxicology Toxicology 320:56-66.
Fisher,M., Arbuckle, T.E., Wade, M., Haines, D.A. Do perfluoroalkyl substances affect metabolic function and plasma lipids?—Analysis of the 2007–2009, Canadian Health Measures Survey (CHMS) Cycle 1. Environ Res. 2013 Feb;121:95-103.
Ernest SR, Wade MG, Lalancette C, Ma YQ, Berger RG, Robaire B, Hales BF. 2012. Effects of chronic exposure to an environmentally relevant mixture of brominated flame retardants on the reproductive and thyroid system in adult male rats. Toxicol Sci. 127:498-5071.
Wade MG, Lee A, Williams A, Yauk C.2008 Methoxyacetic acid-induced death of spermatocytes is associated with histone hyperacetylation Biol Reprod 78: 822-831.
Society of Toxicology of Canada