Dr. Michele C. Loewen

Image Michele C. Loewen
Senior Research Officer

I am a biochemist specializing in protein structure-function (interactions and engineering). I work accross a spectrum of fields focussed on the protection of Canada's agricultural crops and the value-added bioprocessing of agricultural-derived biomass.

Key publications


  • Diddi N, Lai L, Brookbank BP, Hussain S, Nambara E, Todd C, Nourimand M, Tar'an B, Song D, Holbrook L, Doshi K, Loewen MC, Luna EK, Shipp J, Leach JE, Robinson SJ, Abrams SR. (2021) 3'-(Phenyl alkynyl) analogs of abscisic acid: synthesis and biological activity of potent ABA antagonists. Org Biomol Chem. Mar 17. doi: 10.1039/d1ob00166c. Epub ahead of print.
  • Demissie ZA, Robinson KA, Loewen MC. (2021) Draft genome resources for the plant-beneficial fungi Clonostachys rosea strains ACM941 and 88-710. Mol Plant Microbe Interact. Jan 6. doi: 10.1094/MPMI-10-20-0294-A. Epub ahead of print.


  • Buhrow LM, Liu Z, Cram D, Sharma T, Foroud NA, Pan Y, Loewen MC. (2020) Wheat transcriptome profiling reveals abscisic and gibberellic acid treatments regulate early-stage phytohormone defense signaling, cell wall fortification, and metabolic switches following Fusarium graminearum-challenge.  bioRxiv 2020.09.17.302737; doi: https://doi.org/10.1101/2020.09.17.302737
  • Demissie ZA, Huang F, Song H, Todd AT, Vrinten P, Loewen MC. (2020) Barley "uzu" and Wheat "uzu-like" Brassinosteroid Receptor BRI1 Kinase Domain Variations Modify Phosphorylation Activity In Vitro. Biochemistry. 59:2986-2997. doi: 10.1021/acs.biochem.0c00424.
  • Rajagopalan N, Lu Y, Burton IW, Monteil-Rivera F, Halasz A, Reimer E, Tweidt, R, Brûlé-Babel A, Kutcher HR, You FM, Cloutier S, Cuperlovic-Culf M, Hiebert CW, McCallum BD, Loewen MC. (2020) A phenylpropanoid diglyceride associates with the leaf rust resistance Lr34res gene in wheat. Phytochemistry. 178:112456. doi:10.1016/j.phytochem.2020.112456.
  • Sridhar PS, Trofimova D, Subramaniam R, González-Peña Fundora D, Foroud NA, Allingham JS, Loewen MC. (2020) Ste2 receptor-mediated chemotropism of Fusarium graminearum contributes to its pathogenicity against wheat. Sci Rep. 10:10770. doi: 10.1038/s41598-020-67597-z.
  • Demissie ZA, Witte T, Robinson KA, Sproule A, Foote SJ, Johnston A, Harris LJ, Overy DP, Loewen MC. (2020) Transcriptomic and Exometabolomic Profiling Reveals Antagonistic and Defensive Modes of Clonostachys rosea Action Against Fusarium graminearum. Mol Plant Microbe Interact. 33:842-858. doi: 10.1094/MPMI-11-19-0310-R.


  • Demissie ZA, Brown WG, Loewen MC. (2019). A Universally Primed-Polymerase Chain Reaction (UPPCR) Marker to Discriminate Clonostachys rosea ACM941 from Related Strains. J Fungi. 5(39)
  • Luu K, Rajagopalan N, Ching JCH, Loewen ME, Loewen MC. (2019). The malate-activated ALMT12 anion channel in the grass Brachypodium distachyon is co-activated by Ca2+/calmodulin. Journal of Biological Chemistry. 294: 6142-6156.


  • Demissie ZA, Foote S, Tan Y, Loewen MC. (2018). Profiling of the transcriptomic responses of Clonostachys rosea upon treatment with Fusariumgraminearum secretome. Frontiers in Microbiology. 9(1061)
  • Loewen PC, Switala J, Wells JP, Huang F, Zara AT, Allingham JS, Loewen MC. (2018). Structure and Function of a Lignostilbene-α,β-dioxygenase orthologue from Pseudomonas brassicacearum. BMC Biochemistry. 19(8).


  • Cuperlovic-Culf M, Loewen M, Rajagopalan N, Surendra A. (2017). Perspectives on the specific targeting of Fusarium graminearum for the development of alternative Head Blight treatment approaches. Plant Pathology. 66: 1391-1403.


  • Choudhary P & Loewen MC. (2016). Evidence for a role for S. cerevisiae alpha-arrestin Art1 (Ldb19) in mating projection and zygote formations.Cell Biol Int. 40: 83-90.
  • Rajagopalan N, Nelson KM, Douglas AF, Jheequt V, Alacorn IQ, McKenna SA, Surpin M, Loewen MC1, Abrams SR. 1.corresponding author. (2016). Abscisic Acid Analogues That Act as Universal or Selective Antagonists of Phytohormone Receptors.Biochemistry. 55: 5155-5164.
  • Gordon C, Rajagopalan N, Riseeuw E, Surpin M, Ball F, Barber C, Buhrow, LM, Clark SM, Page, JE, Todd, CD, Abrams SR, Loewen MC. (2016). Identification of T. aestivum abscisic acid receptors and evidence of their role in Fusarium Head Blight.PLoS One. 11: e0164996.
  • Cuperlovich-Culf M, Rajagopalan N, Tulpan D, Loewen MC. (2016). Metabolomics and Cheminformatics analysis of Antifungal Function of Plant Metabolites.Metabolites. 6(4): E31.
  • Choudhary P & Loewen MC. (2016). Quantification of mutation-derived bias for alternate mating functionalities of the Saccharomyces cerevisiae Ste2p pheromone receptor.J Biochem. 159: 49-58.
  • Buhrow LM, Cram D, Tulpan D, Foroud NA, Loewen MC. (2016). Exogenous abscisic acid and gibberellic acid elicit opposing effects on Fusarium graminearum infection in wheat.. Phytopathology. 106: 186-196.
  • Rajagopalan N, Halasz A, Lu Y, Liu E, Monteil-Rivera F, Loewen MC. (2016). Probing allocrite preferences of two naturally occurring variants of the wheat LR34 ABC transporter.Biochem and Cell Biol.94: 459-470.
  • Panwar,V.,McCallum,B.,Jordan,M.,Loewen,M.,Fobert,P.,McCartney,C.,Bakkeren,G. (2016). RNA Silencing Approaches for Identifying Pathogenicity and Virulence ElementsTowards Engineering Crop Resistance To Plant Pathogenic Fungi.CAB Reviews. 11(027): 1-13.
  • Buhrow LM, Clark SM, Loewen MC. (2016). Identification of an attenuated barley stripe mosaic virus for the virus-induced gene silencing of pathogenesis-related wheat genes. Plant Methods. 12: 12.

Research facility

100 Sussex Drive
Ottawa, ON K1N 5A2


Adjunct Professor, Queen's University, Department of Biomedical and Molecular Sciences. Link

Adjunct Professor, University of Ottawa, Department of Chemistry and Biomolecular Sciences.Link