Dr. Francesco Marchetti

Current research and/or projects

Heritable effects of environmental mutagens and carcinogens.  Applied genetic toxicology for regulatory decision making.

  • Development and evaluation of in vivo tools for mutagenicity assessment
  • Reproductive toxicity of environmental mutagens
  • Discovery of physiological, environmental and genetic factors affecting male- and female-mediated heritable risk
  • Sperm biomarkers for fertility and genetic damage
  • Hazard and risk assessment of environmental mutagens

Professional activities / interests

  • Incoming Editor-in-Chief, Environmental & Molecular Mutagenesis
  • Editorial Board Member - Mutation Research, Genetic Toxicoloty and Environmental Mutagenesis
  • Councilor, Environmental Mutagen Society

Education and awards

Summa Cum Laude - Doctor of Biological Sciences; University of Rome, Italy  (1990)

Postdoctral Fellow - Louisiana State University Medical Center, Louisiana, USA  (1991-1994)

Postdoctral Fellow - Lawrence Livermore National Laboratory, California, USA (1994-1997)

Key publications

Marchetti F, Rowan-Carroll A, Williams A, Polyzos A, Berndt-Weis ML, Yauk CL (2011) Sidestream tobacco smoke is a male germ cell mutagen. Proceedings of the National Academy of Sciences, USA, 108:12811-12814. Epub: July 18; 2011. http://www.pnas.org/content/108/31/12811.long

Xing C, Marchetti F, Li G, Weldon RH, Kurthovich E, Suzanne Y, Schmid TE, Zhang L, Rappaport S, Waidyanatha S, Wyrobek AJ, Eskenazi B (2010) Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environmental Health Perspectives, 118:833-839 http://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.0901531

Leland S, Nagarajan P, Polyzos A, Thomas A, Samaan G, Donnell R, Marchetti F, Venkatachalam S (2009) Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proceedings of the National Academy of Sciences USA, 106:12776-12781. Epub July 17, 2009. http://www.pnas.org/content/106/31/12776.long

Piña-Guzmán B, Sánchez-Gutiérrez M, Marchetti F, Hernández-Ochoa I, Solís-Heredia MJ, Quintanilla-Vega B (2009) Methyl-parathion decreases mouse sperm function and fertilizing capacity by targeting spermatocytes and maturing spermatozoa. Toxicology and Applied Pharmacology, 238:141-149. Epub May 13, 2009. http://www.sciencedirect.com/science/article/pii/S0041008X09001859

Polyzos A, Schmid T, Pina-Guzman AB, Quintanilla-Vega B, Marchetti F (2009) Differential sensitivity of male germ cells to mainstream and sidestream smoke in the mouse. Toxicology and Applied Pharmacology; 237:298-305. Epub Apr 5, 2009. http://www.sciencedirect.com/science/article/pii/S0041008X09001392

Marchetti F, Bishop J, Lowe X and Wyrobek AJ (2008) Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Toxicological Sciences 107:194-205; Epub Oct 16, 2008. http://toxsci.oxfordjournals.org/content/107/1/194.long

Young S, Eskenazi B, Marchetti F, Block G, Wyrobek AJ (2008) The association of folate, zing and antioxidant intake on sperm aneuploidy in healthy non-smoking men. Human Reproduction 23:1014-22. Epub March 19, 2008. http://humrep.oxfordjournals.org/content/23/5/1014.long

Marchetti F, Wyrobek AJ (2008) DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage. DNA Repair. 7:572-581; Epub February 20, 2008. http://www.sciencedirect.com/science/article/pii/S1568786407004466

Marchetti F, Essers J, Kanaar R, Wyrobek AJ (2007) Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations. Proceedings of the National Academy of Sciences USA 104:17725-17729, Epub October 31. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077046/?tool=pubmed

Marchetti F, Pearson F, Bishop JB and Wyrobek AJ (2005) Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. Human Reproduction, 21:888-895. Epub: November 25, http://humrep.oxfordjournals.org/content/21/4/888.long