Dr. Carolyn Fitzsimmons

Image Carolyn Fitzsimmons
Research Scientist, Bovine Genetics

Co-located at the University of Alberta. Working in the area of the improvement of livestock production via genetic methods, with a specific interest in RFI, epigenetics, and fetal programming.

Current research and/or projects

2019 – PI of “Nutritional Epigenetic Effects in Cattle”. (AAFC A-base, 2019-2023)

2019 – Collaborator on “Development of functional genomic prediction platform for industry application”. (PIs Li C and Basarab J, Genome Alberta, 2019-2020)

2018 – Collaborator on “2018F095R - Genetic and microbial markers for rumen functions and implications in improving cattle feed efficiency”. (PI- Guan L, Alberta Agriculture and Forestry, 2018-2020)

2018 – Collaborator on “Genetic analyses of feed intake, feed efficiency, female fertility, and cow lifetime productivity in beef cattle raised under two environments. (BCRC, 2018-2023)

Research and/or project statements

  • Residual feed intake (RFI) and methane production in cattle, and the general improvement of efficiency and sustainability of beef production.
  • Control of gene expression via dietary means (nutrigenomics).
  • Different genetic potentials for individual responses to changes in diet (nutrigenetics).
  • Permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).

By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to improve beef production.

Key publications

  1. Paradis, F., Wood, K.M., Swanson, K.C., Miller, S.P., McBride, B.W., Fitzsimmons, C. (2017). Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics, [online] 18(1), http://dx.doi.org/10.1186/s12864-017-4051-5

    2017 - View publication details

  2. Añez-Osuna, F., Penner, G. B., Fitzsimmons, C. F., Dugan, M. E. R., Campbell, J., Jefferson, P. G., Lardner, H. A. and McKinnon, J. J. 2017. Effects of low vs. high dietary fat and source of fat on the performance of gestating beef cows and subsequent effects on progeny. ASAS-CSAS Joint Annual Meeting (JAM), July 8-12, 2016, Baltimore, MD, USA.

    2017 - View publication details

  3. Estrella, C.A.S., Kind, K.L., Derks, A., Xiang, R., Faulkner, N., Mohrdick, M., Fitzsimmons, C., Kruk, Z., Grutzner, F., Roberts, C.T., Hiendleder, S. (2017). Remodelling of the bovine placenta: Comprehensive morphological and histomorphological characterization at the late embryonic and early accelerated fetal growth stages, 55 37-46. http://dx.doi.org/10.1016/j.placenta.2017.04.009

    2017 - View publication details

  4. Awda, B.J., Wood, K.M., Keomanivong, F.E., Borowicz, P.P., McBride, B.W., Miller, S.P., Fitzsimmons, C.J., Swanson, K.C. (2017). The influence of pregnancy and plane of nutrition during pregnancy on pancreatic digestive enzymes and insulin-containing cell cluster morphology in beef cows. Canadian Journal of Animal Science, [online] 97(1), 145-153. http://dx.doi.org/10.1139/cjas-2015-0177

    2017 - View publication details

  5. Foroutan, A., Dugan, M.E.R, Stothard, P., Grant, J., Paradis, F., Guan, L.L., McAllister, T.A., Basu, U., Li, C., and Fitzsimmons, C.J. (2016). "Gene expression differences associated with fatty-acid deposition in beef cattle fed diets with supplemental flaxseed.", XXIV Plant and Animal Genomics Conference, San Diego, CA, USA, January 2016. (Abstract)

    2016 - View publication details

  6. Li, C., Ekine-Dzivenu, C., Chen, L., Vinsky, M.D., Basarab, J.A., Aalhus, J.L., Dugan, M.E.R, and Fitzsimmons, C.J. (2015). "Heritability estimates and accuracy of predicting direct genomic breeding values for fatty acid composition of beef cattle.", CASA. (Abstract)

    2015 - View publication details

  7. Chen, L., Ekine-Dzivenu, C., Vinsky, M., Basarab, J., Aalhus, J., Dugan, M.E.R., Fitzsimmons, C., Stothard, P., Li, C. (2015). Genome-wide association and genomic prediction of breeding values for fatty acid composition in subcutaneous adipose and longissimus lumborum muscle of beef cattle, 16(1), http://dx.doi.org/10.1186/s12863-015-0290-0

    2015 - View publication details

  8. Akanno, E.C., Plastow, G., Fitzsimmons, C., Miller, S.P., Baron, V., Ominski, K., Basarab, J.A., Civetta, A. (2015). Genome-wide association for heifer reproduction and calf performance traits in beef cattle, 58(12), 549-557. http://dx.doi.org/10.1139/gen-2015-0031

    2015 - View publication details

  9. Paradis, F., Yue, S., Grant, J.R., Stothard, P., Basarab, J.A., Fitzsimmons, C. (2015). Transcriptomic analysis by RNA sequencing reveals that hepatic interferon-induced genes may be associated with feed efficiency in beef heifers. Journal of Animal Science, [online] 93(7), 3331-3341. http://dx.doi.org/10.2527/jas.2015-8975

    2015 - View publication details

  10. Li, C., Dugan, M.E.R, Aalhus, J.L., Fitzsimmons, C.J., Basarab, J.A., Buchanan, F.C., Chen, L., Ekine-Dzivenu, C., Stothard, P., Curtis, J.M., Bruce, H.L., Wang, Z., and Okine, E.K. (2014). "Genetic Influence of Host Animal on Fatty Acid Profile in Beef.", Beef and Ranch Report, pp. 34-35.

    2014 - View publication details

  11. Foroutan, A., Stothard, P., Grant, J., Paradis, F., Guan, L.L., Dugan, M.E.R, McAllister, T.A., Basu, U., McLean, K.L., and Fitzsimmons, C.J. (2014). "Transcriptional analysis in Longissimus thoracis muscle, subcutaneous and kidney fat of cattle fed diets with supplemental flaxseed.", XXII Plant & Animal Genome Conference, Town & Country Convention Center, San Diego, CA, USA, January 10-15, 2014.

    2014 - View publication details

  12. Fitzsimmons, C.J., Muhire, G., Paradis, F., McKeown, L.E., Straathof, C., Block, H.C., Colazo, M.G., Li, C., Yaremcio, B., Basarab, J.A., and Bruce, H.L. (2014). "Pregnant beef heifers categorized by residual feed intake measured in adolescence exhibit differential intake andfeeding behaviors when fed a restricted diet. 2014.", ADSA-ASAS 2014 Joint Annual Meeting, Kansas City, MO, USA, July 20-24, 2014. (Poster)

    2014 - View publication details

  13. Li, C., Dugan, M.E.R, Aalhus, J.L., Fitzsimmons, C.J., Basarab, J.A., Buchanan, F.C., Chen, L., Ekine-Dzivenu, C., Stothard, P., Curtis, J., Bruce, H.L., Wang, Z., and Okine, E.K. (2014). "Genetic Influence of Host Animal on Fatty Acid Profile in Beef.", University of Alberta Kinsella Day, Kinsella, AB, Canada, August 13, 2014. (Poster)

    2014 - View publication details

  14. Chen, L., Vinsky, M.D., Ekine, C., Basarab, J.A., Aalhus, J.L., Dugan, M.E.R, Curtis, J., Fitzsimmons, C.J., Stothard, P., and Li, C. (2014). "Genomic prediction of direct genomic breeding values for fatty acid concentrations in subcutaneous adipose and longissimus lumborum muscle of beef cattle.", Livestock Gentec 5th Annual conference, Edmonton, AB, Canada, August 12-14, 2014. (Poster)

    2014 - View publication details

  15. Li, C., Aalhus, J.L., Dugan, M.E.R, Fitzsimmons, C.J., Basarab, J.A., Curtis, J., Stothard, P., Okine, E.K., Wang, Z., Bruce, H.L., and Buchanan, F.C. (2014). Identifying DNA markers for enhancing beneficial fatty acids in beef, Final project report, 33 pages to Alberta Livestock and Meat Agency (ALMA). (Report)

    2014 - View publication details

  16. Xiang, R., Lee, A.M.C., Eindorf, T., Javadmanesh, A., Ghanipoor-Samami, M., Gugger, M., Fitzsimmons, C.J., Kruk, Z.A., Pitchford, W.S., Leviton, A.J., Thomsen, D.A., Beckman, I., Anderson, G.I., Burns, B.M., Rutley, D.L., Xian, C.J., Hiendleder, S. (2014). Widespread differential maternal and paternal genome effects on fetal bone phenotype at mid-gestation, 29(11), 2392-2404. http://dx.doi.org/10.1002/jbmr.2263

    2014 - View publication details

  17. Wood, K.M., Montanholi, Y.R., Fitzsimmons, C.F., Miller, S.P., Mcbride, B.W., Swanson, K.C. (2014). Characterization and evaluation of residual feed intake measured in mid- to late-gestation mature beef cows and relationships with circulating serum metabolites and linear body measurements. Canadian Journal of Animal Science, [online] 94(3), 499-508. http://dx.doi.org/10.4141/CJAS2013-165

    2014 - View publication details

  18. Thompson, S., Ullenboom, T.R., Crow, G.H., Basarab, J.A., Wittenberg, K.M., Baron, V.S., Fitzsimmons, C.J., and Ominski, K.H. (2013). "Repeated measures of residual feed intake in growing beef bulls fed forage and grainbased diets.", CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013, P13, pp. 29. (Poster)

    2013 - View publication details

  19. Thompson, S., Schaefer, A.L., Crow, G.H., Basarab, J.A., Colyn, J.J., Wittenberg, K.M., Baron, V.S., Fitzsimmons, C.J., and Ominski, K.H. (2013). "Predicting residual feed intake in beef bulls by measuring radiated heat loss through infrared thermography.", CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013, O20-GS, pp. 11.

    2013 - View publication details

  20. Foroutan, A., Stothard, P., Grant, J., Paradis, F., Guan, L.L., Dugan, M.E.R, Basu, U., McLean, K.L., and Fitzsimmons, C.J. (2013). "Transcriptional analysis in Longissimus dorsi muscle and subcutaneous fat of the cattle fed diets with supplemental flaxseed.", Livestock Gentec Conference, Edmonton, Canada, October, 2013. (Abstract)

    2013 - View publication details

Research facility

6000 C and E Trail
Lacombe, AB T4L 1W1
Canada

Expertise

Language

English

Other languages

Swedish