Dr. Carolyn Fitzsimmons

Image Carolyn Fitzsimmons
Research Scientist, Bovine Genetics

Co-located at the University of Alberta. Working in the area of the improvement of livestock production via genetic methods, with a specific interest in RFI, epigenetics, and fetal programming.

Current research and/or projects

2019 – PI of “Nutritional Epigenetic Effects in Cattle”. (AAFC A-base, 2019-2023)

2019 – Collaborator on “Development of functional genomic prediction platform for industry application”. (PIs Li C and Basarab J, Genome Alberta, 2019-2020)

2018 – Collaborator on “2018F095R - Genetic and microbial markers for rumen functions and implications in improving cattle feed efficiency”. (PI- Guan L, Alberta Agriculture and Forestry, 2018-2020)

2018 – Collaborator on “Genetic analyses of feed intake, feed efficiency, female fertility, and cow lifetime productivity in beef cattle raised under two environments. (BCRC, 2018-2023)

Research and/or project statements

  • Residual feed intake (RFI) and methane production in cattle, and the general improvement of efficiency and sustainability of beef production.
  • Control of gene expression via dietary means (nutrigenomics).
  • Different genetic potentials for individual responses to changes in diet (nutrigenetics).
  • Permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).

By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to improve beef production.

Key publications

  1. Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M.V., Wishart, D.S. (2020). Serum metabolite biomarkers for predicting residual feed intake (RFI) of young angus bulls. Metabolites, [online] 10(12), 1-20. http://dx.doi.org/10.3390/metabo10120491

    2020 - View publication details

  2. Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2020). Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes. Scientific Reports, [online] 10(1), http://dx.doi.org/10.1038/s41598-020-73885-5

    2020 - View publication details

  3. Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J., Thundathil, J. (2020). Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets, 60(12), 1491-1502. http://dx.doi.org/10.1071/AN19524

    2020 - View publication details

  4. Foroutan, A., Fitzsimmons, C., Mandal, R., Piri‐moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L., Wishart, D.S. (2020). The bovine metabolome. Metabolites, [online] 10(6), 1-26. http://dx.doi.org/10.3390/metabo10060233

    2020 - View publication details

  5. Hadinia, S.H., Carneiro, P.R.O., Fitzsimmons, C.J., Bédécarrats, G.Y., Zuidhof, M.J. (2020). Post-photostimulation energy intake accelerated pubertal development in broiler breeder pullets. Poultry Science, [online] 99(4), 2215-2229. http://dx.doi.org/10.1016/j.psj.2019.11.065

    2020 - View publication details

  6. Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows. II. Effects on the postpartum performance of the dam and the progeny. Journal of Animal Science, [online] 97(7), 3120-3141. http://dx.doi.org/10.1093/jas/skz172

    2019 - View publication details

  7. Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows: I. Effects on the prepartum performance of the dam and birth weight of the progeny. Journal of Animal Science, [online] 97(7), 3103-3119. http://dx.doi.org/10.1093/jas/skz171

    2019 - View publication details

  8. Li, F., Li, C., Chen, Y., Liu, J., Zhang, C., Irving, B., Fitzsimmons, C., Plastow, G., Guan, L.L. (2019). Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle. Microbiome, [online] 7(1), http://dx.doi.org/10.1186/s40168-019-0699-1

    2019 - View publication details

  9. Añez-Osuna, F., Penner, G.B., Campbell, J., Damiran, D., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., McKinnon, J.J., Lardner, H.A. (2019). Effects of postpartum fat supplementation and source on the reproductive performance of lactating young beef cows grazing cool-season grass pastures. Applied Animal Science, [online] 35(2), 185-198. http://dx.doi.org/10.15232/aas.2018-01791

    2019 - View publication details

  10. Akanno, E.C., Ekine-Dzivenu, C., Chen, L., Vinsky, M., Abo-Ismail, M.K., Macneil, M.D., Plastow, G., Basarab, J., Li, C., Fitzsimmons, C. (2019). Evaluation of a genomic-enhanced sorting system for feeder cattle. Journal of Animal Science, [online] 97(3), 1066-1075. http://dx.doi.org/10.1093/jas/skz026

    2019 - View publication details

  11. Hare, K.S., Wood, K.M., Acton, K., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on prepartum BW, ruminal fermentation, nitrogen balance, and skeletal muscle catabolism. Journal of Animal Science, [online] 97(1), 407-423. http://dx.doi.org/10.1093/jas/sky410

    2019 - View publication details

  12. Johnson, C., Fitzsimmons, C., Colazo, M., Li, C., Kastelic, J., Thundathil, J. (2019). Impacts of residual feed intake and pre-natal diet on reproductive potential of bulls. Animal Production Science, [online] 59(10), 1827-1836. http://dx.doi.org/10.1071/AN18301

    2019 - View publication details

  13. Hare, K.S., Wood, K.M., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on postpartum ruminal fermentation, blood metabolites, skeletal muscle catabolism, colostrum composition, milk yield and composition, and calf growth performance. Journal of Animal Science, [online] 97(1), 437-455. http://dx.doi.org/10.1093/jas/sky413

    2019 - View publication details

  14. F Añez-Osuna, G Penner, C Fitzsimmons, M Dugan, J Campbell, P Jefferson, H Lardner, J McKinnon, 351 Effects of level and source of fat in the diet of gestating beef cows on progeny performance., Journal of Animal Science, Volume 96, Issue suppl_3, December 2018, Page 175, https://doi.org/10.1093/jas/sky404.381

    2018 - View publication details

  15. Mukiibi, R., Vinsky, M., Keogh, K.A., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2018). Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle, 8(1), http://dx.doi.org/10.1038/s41598-018-25605-3

    2018 - View publication details

  16. Li, X., Yan, Q., Tang, S., Tan, Z., Fitzsimmons, C.J., Yi, K. (2018). Effects of maternal feed intake restriction during pregnancy on the expression of growth regulation, imprinting and epigenetic transcription-related genes in foetal goats, 198 90-98. http://dx.doi.org/10.1016/j.anireprosci.2018.09.005

    2018 - View publication details

  17. Difford, G.F., Plichta, D.R., Løvendahl, P., Lassen, J., Noel, S.J., Højberg, O., Wright, A.-D.G., Zhu, Z., Kristensen, L., Nielsen, H.B., Guldbrandtsen, B., Sahana, G. (2018). Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows, 14(10), http://dx.doi.org/10.1371/journal.pgen.1007580

    2018 - View publication details

  18. Ekine-Dzivenu C, Akanno EC, Chen L, McKeown L, Irving B, Baker L, Vinsky M, Miller S, Wang Z, Crowley J, Colazo M, Ambrose D, Juarez M, Bruce H, MacNeil MD, Plastow G, Basarab J, Li C, & Fitzsimmons C. (2018) Improvement of cow feed efficiency using molecular breeding values for residual feed intake - The “Kinsella Breeding Project”. In: Proceedings of the World Congress on Genetics Applied to Livestock Production. vol. Electronic Poster Session - Genetic Gain - Breeding Strategies 2: 809.

    2018 - View publication details

  19. Paradis, F., Wood, K.M., Swanson, K.C., Miller, S.P., McBride, B.W., Fitzsimmons, C. (2017). Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics, [online] 18(1), http://dx.doi.org/10.1186/s12864-017-4051-5

    2017 - View publication details

  20. Añez-Osuna, F., Penner, G. B., Fitzsimmons, C. F., Dugan, M. E. R., Campbell, J., Jefferson, P. G., Lardner, H. A. and McKinnon, J. J. 2017. Effects of low vs. high dietary fat and source of fat on the performance of gestating beef cows and subsequent effects on progeny. ASAS-CSAS Joint Annual Meeting (JAM), July 8-12, 2016, Baltimore, MD, USA.

    2017 - View publication details

Research facility

6000 C and E Trail
Lacombe, AB T4L 1W1
Canada

Expertise

Language

English

Other languages

Swedish