Dr. Carolyn Fitzsimmons
Co-located at the University of Alberta. Working in the area of the improvement of livestock production via genetic methods, with a specific interest in RFI, epigenetics, and fetal programming.
Current research and/or projects
2019 – PI of “Nutritional Epigenetic Effects in Cattle”. (AAFC A-base, 2019-2023)
2019 – Collaborator on “Development of functional genomic prediction platform for industry application”. (PIs Li C and Basarab J, Genome Alberta, 2019-2020)
2018 – Collaborator on “2018F095R - Genetic and microbial markers for rumen functions and implications in improving cattle feed efficiency”. (PI- Guan L, Alberta Agriculture and Forestry, 2018-2020)
2018 – Collaborator on “Genetic analyses of feed intake, feed efficiency, female fertility, and cow lifetime productivity in beef cattle raised under two environments. (BCRC, 2018-2023)
Research and/or project statements
- Residual feed intake (RFI) and methane production in cattle, and the general improvement of efficiency and sustainability of beef production.
- Control of gene expression via dietary means (nutrigenomics).
- Different genetic potentials for individual responses to changes in diet (nutrigenetics).
- Permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).
By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to improve beef production.
Key publications
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Behrouzi A., Fitzsimmons C., McKeown L., Basarab J., Bork E. 2022. Methane and carbon dioxide emissions from crossbred beef cattle grazing native pastures. Poster and talk at the 8th International Greenhouse Gas & Animal Agriculture Conference, Orlando, FL, USA. June 2022.
2022 - View publication details
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Na SW., Zhou M., Bork E., Fitzsimmons C., Guan L. 2022. Assessment of rumen and fecal short chain fatty acids profiles and microbial populations in rumen fluid and feces of beef cows under two different feeding regimes. 2022 Animal Nutrition Conference of Canada, Saskatoon, Canada. May 2022.
2022 - View publication details
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Foroutan, A., Fitzsimmons, C., Mandal, R., Berjanskii, M.V., Wishart, D.S. (2020). Serum metabolite biomarkers for predicting residual feed intake (RFI) of young angus bulls. Metabolites, [online] 10(12), 1-20. http://dx.doi.org/10.3390/metabo10120491
2020 - View publication details
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Mukiibi, R., Johnston, D., Vinsky, M., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2020). Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes. Scientific Reports, [online] 10(1), http://dx.doi.org/10.1038/s41598-020-73885-5
2020 - View publication details
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Johnson, C., Fitzsimmons, C., Kovalchuk, I., Kastelic, J., Thundathil, J. (2020). Testis-specific changes in gene expression of post-pubertal beef bulls divergent for residual feed intake and exposure to different pre-natal diets, 60(12), 1491-1502. http://dx.doi.org/10.1071/AN19524
2020 - View publication details
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Foroutan, A., Fitzsimmons, C., Mandal, R., Piri‐moghadam, H., Zheng, J., Guo, A., Li, C., Guan, L.L., Wishart, D.S. (2020). The bovine metabolome. Metabolites, [online] 10(6), 1-26. http://dx.doi.org/10.3390/metabo10060233
2020 - View publication details
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Hadinia, S.H., Carneiro, P.R.O., Fitzsimmons, C.J., Bédécarrats, G.Y., Zuidhof, M.J. (2020). Post-photostimulation energy intake accelerated pubertal development in broiler breeder pullets. Poultry Science, [online] 99(4), 2215-2229. http://dx.doi.org/10.1016/j.psj.2019.11.065
2020 - View publication details
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Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows: I. Effects on the prepartum performance of the dam and birth weight of the progeny. Journal of Animal Science, [online] 97(7), 3103-3119. http://dx.doi.org/10.1093/jas/skz171
2019 - View publication details
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Añez-Osuna, F., Penner, G.B., Campbell, J., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., Lardner, H.A., McKinnon, J.J. (2019). Level and source of fat in the diet of gestating beef cows. II. Effects on the postpartum performance of the dam and the progeny. Journal of Animal Science, [online] 97(7), 3120-3141. http://dx.doi.org/10.1093/jas/skz172
2019 - View publication details
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Li, F., Li, C., Chen, Y., Liu, J., Zhang, C., Irving, B., Fitzsimmons, C., Plastow, G., Guan, L.L. (2019). Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle. Microbiome, [online] 7(1), http://dx.doi.org/10.1186/s40168-019-0699-1
2019 - View publication details
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Añez-Osuna, F., Penner, G.B., Campbell, J., Damiran, D., Dugan, M.E.R., Fitzsimmons, C.J., Jefferson, P.G., McKinnon, J.J., Lardner, H.A. (2019). Effects of postpartum fat supplementation and source on the reproductive performance of lactating young beef cows grazing cool-season grass pastures. Applied Animal Science, [online] 35(2), 185-198. http://dx.doi.org/10.15232/aas.2018-01791
2019 - View publication details
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Akanno, E.C., Ekine-Dzivenu, C., Chen, L., Vinsky, M., Abo-Ismail, M.K., Macneil, M.D., Plastow, G., Basarab, J., Li, C., Fitzsimmons, C. (2019). Evaluation of a genomic-enhanced sorting system for feeder cattle. Journal of Animal Science, [online] 97(3), 1066-1075. http://dx.doi.org/10.1093/jas/skz026
2019 - View publication details
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Hare, K.S., Wood, K.M., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on postpartum ruminal fermentation, blood metabolites, skeletal muscle catabolism, colostrum composition, milk yield and composition, and calf growth performance. Journal of Animal Science, [online] 97(1), 437-455. http://dx.doi.org/10.1093/jas/sky413
2019 - View publication details
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Hare, K.S., Wood, K.M., Acton, K., Fitzsimmons, C., Penner, G.B. (2019). Oversupplying metabolizable protein in late gestation for beef cattle: Effects on prepartum BW, ruminal fermentation, nitrogen balance, and skeletal muscle catabolism. Journal of Animal Science, [online] 97(1), 407-423. http://dx.doi.org/10.1093/jas/sky410
2019 - View publication details
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Johnson, C., Fitzsimmons, C., Colazo, M., Li, C., Kastelic, J., Thundathil, J. (2019). Impacts of residual feed intake and pre-natal diet on reproductive potential of bulls. Animal Production Science, [online] 59(10), 1827-1836. http://dx.doi.org/10.1071/AN18301
2019 - View publication details
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F Añez-Osuna, G Penner, C Fitzsimmons, M Dugan, J Campbell, P Jefferson, H Lardner, J McKinnon, 351 Effects of level and source of fat in the diet of gestating beef cows on progeny performance., Journal of Animal Science, Volume 96, Issue suppl_3, December 2018, Page 175, https://doi.org/10.1093/jas/sky404.381
2018 - View publication details
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Mukiibi, R., Vinsky, M., Keogh, K.A., Fitzsimmons, C., Stothard, P., Waters, S.M., Li, C. (2018). Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle, 8(1), http://dx.doi.org/10.1038/s41598-018-25605-3
2018 - View publication details
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Li, X., Yan, Q., Tang, S., Tan, Z., Fitzsimmons, C.J., Yi, K. (2018). Effects of maternal feed intake restriction during pregnancy on the expression of growth regulation, imprinting and epigenetic transcription-related genes in foetal goats, 198 90-98. http://dx.doi.org/10.1016/j.anireprosci.2018.09.005
2018 - View publication details
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Difford, G.F., Plichta, D.R., Løvendahl, P., Lassen, J., Noel, S.J., Højberg, O., Wright, A.-D.G., Zhu, Z., Kristensen, L., Nielsen, H.B., Guldbrandtsen, B., Sahana, G. (2018). Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows, 14(10), http://dx.doi.org/10.1371/journal.pgen.1007580
2018 - View publication details
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Ekine-Dzivenu C, Akanno EC, Chen L, McKeown L, Irving B, Baker L, Vinsky M, Miller S, Wang Z, Crowley J, Colazo M, Ambrose D, Juarez M, Bruce H, MacNeil MD, Plastow G, Basarab J, Li C, & Fitzsimmons C. (2018) Improvement of cow feed efficiency using molecular breeding values for residual feed intake - The “Kinsella Breeding Project”. In: Proceedings of the World Congress on Genetics Applied to Livestock Production. vol. Electronic Poster Session - Genetic Gain - Breeding Strategies 2: 809.
2018 - View publication details
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