Chantal Farmer

Image Chantal Farmer
Research scientist

Research scientist in swine lactation biology. Projects aim at increasing sow milk yield and stimulating mammary development in growing gilts and during the end of gestation.

Key publications

  1. Mathews, A.T., Banks, C.M., Trott, J.F., Sainz, R.D., Farmer, C., Pendergast, I.I., Hovey, R.C. (2021). Metoclopramide induces preparturient, low-level hyperprolactinemia to increase milk production in primiparous sows. Domestic Animal Endocrinology, [online] 74 http://dx.doi.org/10.1016/j.domaniend.2020.106517

    2021 - View publication details

  2. The study objective was to determine the effects of hyperprolactinemia on the mammary parenchymal
    transcriptome in late-pregnant gilts. Gilts were divided into 3 groups on day 90 of gestation to receive IM injections of 1) canola oil (CTL, n = 18) until day 109 of gestation, 2) domperidone (dopamine antagonist)
    until day 96 (T7, n = 17) or, 3) domperidone until day 109 (T20, n = 17). Mammary glands were collected
    on day 110 and parenchymal tissue was sampled for transcriptomic analyses. Total RNA was isolated from
    6 CTL and 6 T20 gilts for microarray analysis. The GeneChip® Porcine Gene 1.0 ST Array (19,202 genes)
    was used for hybridization. Array quality control, data normalization and expression level analyses were
    performed with the Affymetrix Expression Console and Transcriptome Analysis Console (TAC) software. Using a threshold cut-off of 1.5 fold (P < 0.05), a total of 313 upregulated and 480 downregulated gene transcripts were identified in T20 vs CTL gilts. A qPCR validation analysis of selected upregulated (n = 13) and downregulated (n = 13) genes was conducted on all animals (CTL, T7, T20). The MIXED procedure of SAS was used for statistical analyses. All selected genes were validated for the CTL vs T20 comparison (P < 0.01). Only 4 selected genes (CAMK1G, COL9A1, P2RX7, TDRD1) were downregulated in the T7 treatment (vs CTL, P < 0.05). Functional analyses of differentially expressed genes were performed using the PANTHER classification system. The top upregulated Biological Process enriched GO terms were Inflammatory Response (GO:0006954) and Response to Lipid (GO:0033993). The Positive Regulation of Cell Population Proliferation (GO:0008284) and Regulation of Cellular Catabolic Process (GO:0031329) GO terms were identified for downregulated genes. Results suggest that a sustained hyperprolactinemia during latepregnancy (T20 treatment) may increase mammary inflammatory response and reduce cell proliferation.

    2020 - View publication details

  3. Caron, A., Palin, M.F., Hovey, R.C., Cohen, J., Laforest, J.P., Farmer, C. (2020). Effects of sustained hyperprolactinemia in late gestation on mammary development of gilts. Domestic Animal Endocrinology, [online] 72 http://dx.doi.org/10.1016/j.domaniend.2019.106408

    2020 - View publication details

  4. Krogh, U., Farmer, C., Huber, L.A., Theil, P.K., Trottier, N.L. (2020). Impact of arginine supplementation on serum prolactin and mRNA abundance of amino acid transporter genes in mammary tissue of lactating sows. Journal of Animal Science, [online] 98(11), http://dx.doi.org/10.1093/JAS/SKAA335

    2020 - View publication details

  5. Caron, A., Hovey, R.C., Palin, M.F., Cohen, J.R., Laforest, J.P. and Farmer, C. (2019) Effects of sustained hyperprolactinemia in late gestation on mammary development of gilts. Journal of Animal Science, Vol. 97, Suppl. 3: p289, (Abstract PSI-7). https://doi.org/10.1093/jas/skz258.584

    2019 - View publication details

  6. Agyekum, A.K., Columbus, D.A., Farmer, C., Denise Beaulieu, A. (2019). Effects of supplementing processed straw during late gestation on sow physiology, lactation feed intake, and offspring body weight and carcass quality. Journal of Animal Science, [online] 97(9), 3958-3971. http://dx.doi.org/10.1093/jas/skz242

    2019 - View publication details

  7. Farmer, C., Langendijk, P. (2019). Exogenous porcine somatotropin stimulates mammary development in late-pregnant gilts. Journal of Animal Science, [online] 97(6), 2433-2440. http://dx.doi.org/10.1093/jas/skz136

    2019 - View publication details

  8. Farmer, C., Mathews, A.T., Hovey, R.C. (2019). Using domperidone to induce and sustain hyperprolactinemia in late-pregnant gilts. Domestic Animal Endocrinology, [online] 66 14-20. http://dx.doi.org/10.1016/j.domaniend.2018.05.004

    2019 - View publication details

  9. Duarte, C.R.A., Farmer, C., Palin, M.F. (2019). Body condition of late pregnant gilts affects the expression of selected adipokines and their receptors in mammary fat and backfat tissues. Journal of Animal Science, [online] 97(1), 220-230. http://dx.doi.org/10.1093/jas/sky391

    2019 - View publication details

  10. Farmer, C. (2018). Nutritional impact on mammary development in pigs: A review. Journal of Animal Science, [online] 96(9), 3748-3756. http://dx.doi.org/10.1093/jas/sky243

    2018 - View publication details

  11. Beaulieu, D., Farmer, C., Brown, J., Lapointe, J. and Palin, M.F. Increasing sow milk yield and piglet growth via low-cost feeding and management strategies during gestation and/or lactation. In Swine Innovation Porc 2017-2018 Final Report. pp. 14-15.

    2018 - View publication details

  12. Palin, M.F., Farmer, C., Duarte, C.R.A. (2017). Triennial lactation symposium/bolfa: Adipokines affect mammary growth and function in farm animals. Journal of Animal Science, [online] 95(12), 5689-5700. http://dx.doi.org/10.2527/jas2017.1777

    2017 - View publication details

  13. Farmer, C. and Palin, M.F. (2017) Being too thin in late pregnancy is not a good thing for mammary development. Canadian Hog Journal, Fall 2017, pp 48-49.

    2017 - View publication details

  14. Farmer, C., Lessard, M., Knight, C.H., Quesnel, H. (2017). Oxytocin injections in the postpartal period affect mammary tight junctions in sows. Journal of Animal Science, [online] 95(8), 3532-3539. http://dx.doi.org/10.2527/jas.2017.1700

    2017 - View publication details

  15. Palin, M.F., Duarte, C.R.A., Comi, M. and Farmer, C. (2017) Prolactin, prolactin receptor and adiponutrin mRNA Abundances in mammary extraparenchymal tissue of gilts are affected by body condition. ASAS-CSAS Annual Meeting & Trade Show, July 8-12, Baltimore, MD, USA Journal of Animal Science Vol. 95, Supplement 4, p. 171-172 doi:10.2527/asasann.2017.347. (Invited speaker).

    2017 - View publication details

  16. Palin, M.F., Farmer, C., Duarte, C.R.A. (2017) Adipokines affect mammary growth and function in farm animals. Triennal Lactation Symposium and Biology of Lactation of Farm Animals. BOLFA Symposium: The Biology of Lactation - From Genes to Cells to Milk Baltimore, MD, USA, July 8th. (Invited Speaker).

    2017 - View publication details

  17. Farmer, C., Martineau, J.P., Méthot, S., Bussières, D. (2017). Comparative study on the relations between backfat thickness in late-pregnant gilts, mammary development and piglet growth. Translational Animal Science, [online] 1(2), 154-159. http://dx.doi.org/10.2527/tas2017.0018

    2017 - View publication details

  18. Farmer, C., Lapointe, J., Cormier, I. (2017). Providing the plant extract silymarin to lactating sows: Effects on litter performance and oxidative stress in sows. Animal, [online] 11(3), 405-410. http://dx.doi.org/10.1017/S1751731116001919

    2017 - View publication details

  19. Farmer, C., Amezcua, M., Bruckmaier, R., Wellnitz, O., Friendship, R. (2017). Does duration of teat use in first parity affect milk yield and mammary gene expression in second parity?. Journal of Animal Science, [online] 95(2), 681-687. http://dx.doi.org/10.2527/jas2016.1119

    2017 - View publication details

  20. Farmer, C., Robertson, P., Xiao, C.W., Rehfeldt, C., Kalbe, C. (2016). Exogenous genistein in late gestation: Effects on fetal development and sow and piglet performance. Animal, [online] 10(9), 1423-1430. http://dx.doi.org/10.1017/S1751731116000355

    2016 - View publication details

Research facility

2000 College Street
Sherbrooke, QC J1M 0C8
Canada

Language

English
French