Bahram Samanfar, Ph.D.

Image Bahram Samanfar
Research Scientist, and Functional Genomics Team Lead

Dr. Samanfar is a Research Scientist, and Team Lead (functional genomics team) at AAFC, Ottawa-RDC and an Adjunct Professor at Department of Biology, Carleton University. He is a Molecular Geneticist and Applied Genomicist with expertise in Allele-Specific Molecular Marker Developments, Recombination Mapping, Marker-Assisted Selection (Breeding), Functional Genomics, RNA and DNA Sequencing, Proteomics, Transcriptomics, Computational Biology and Bioinformatics, particularly in relation to Soybean (Barley, Bluberry, and Lupin).

Current research and/or projects

Soybean is one of the most important and economically valuable crops in the world. It is the source of vegetative oil and protein for human and animal consumption. Canadian soybean cultivation has a positive slope (increasing) since 2000. Interestingly, there is an increase in soybean production in western Canada recently. Canada has all the resources needed to expand soybean cultivation; so the plan is to expand soybean cultivation further north and west.  In order to do that, one has to face some challenges such as time of flowering and maturity, level of protein, pests and diseases. In my lab, we are trying to address these challenges by genomics, functional genomic, transcriptomics, and bioinformatics approaches.

Dr. Samanfar is a Research Scientist and a Team Lead at AAFC, Ottawa-RDC and an Adjunct Professor at Department of Biology, Carleton University. He is a Molecular Geneticist and Applied Genomicist with expertise in Allele-Specific Molecular Marker Developments, Recombination Mapping, Marker-Assisted Selection (Breeding), Functional Genomics,  Computational Biology and Bioinformatics, particularly in relation to Soybean.

Research and/or project statements

  • Identification and characterization of novel soybean genes involved in:
    • Time of flowering and maturity
    • Seed protein synthesis
    • Economically important pathways
  • Allele-specific marker development (Marker Assisted Selection (MAS) in soybean)
  • Host-pathogen interaction analysis in soybean (SCN-Soybean)
  • Identification and characterization of novel genes involved in health attributes of soybean consumption (human health and allergy)
  • Genomics and Functional Genomics (Systems Biology) of soybean (barley, blueberry, Lupine, yeast & E. coil)
  • Bioinformatics and Computational Biology (Soybean and SCN Functional Genomics)

Professional activities / interests

Genomics /Proteomics and Transcriptomics for Soybean (+ Barley, SCN, Blueberry, Lupine, etc.), Cell and Molecular Biology, Plant Biotechnology, Genetics and Genomics, DNA-based Markers, Allele-Specific Marker Developments, Systems Biology, Molecular Breeding, Host-pathogen Interactions, Bioinformatics, Computational Biology, QTL and GWAS Analysis, Time of Flowering and Maturity (Genetics of Photoperiod Sensitivity) in Soybean, Soybean Seed Protein content, Allergy, Microbiology.

Education and awards

Ph.D. (Carleton University, Canada)

M.Sc. (Paul Sabatier University, France)

M.Sc. (University of Tehran, Iran)

B.Sc. (University of Tehran, Iran)

Key publications

  1. Omidi, K., Jessulat, M., Hooshyar, M., Burnside, D., Schoenrock, A., Kazmirchuk, T., Hajikarimlou, M., Daniel, M., Moteshareie, H., Bhojoo, U., Sanders, M., Ramotar, D., Dehne, F., Samanfar, B., Babu, M., Golshani, A. (2018). Uncharacterized ORF HUR1 influences the efficiency of non-homologous end-joining repair in Saccharomyces cerevisiae. Gene, [online] 639 128-136. http://dx.doi.org/10.1016/j.gene.2017.10.003

    2018 - View publication details

  2. Kazmirchuk, T., Dick, K., Burnside, D.J., Barnes, B., Moteshareie, H., Hajikarimlou, M., Omidi, K., Ahmed, D., Low, A., Lettl, C., Hooshyar, M., Schoenrock, A., Pitre, S., Babu, M., Cassol, E., Samanfar, B., Wong, A., Dehne, F., Green, J.R., Golshani, A. (2017). Designing anti-Zika virus peptides derived from predicted human-Zika virus protein-protein interactions. Computational Biology and Chemistry, [online] 71 180-187. http://dx.doi.org/10.1016/j.compbiolchem.2017.10.011

    2017 - View publication details

  3. Houman Moteshareie, Bahram Samanfar, Ashkan Golshani: Exploration of the novel genes that affect IRES-mediated translation of URE2, a key gene involved in metal detoxification. Canadian Society for Molecular Biosciences (CSMB) 2017, Ottawa, Canada.

    2017 - View publication details

  4. Maryam Hajikarimlou, Bahram Samanfar, Ashkan Golshani: Investigating novel genes with helicase activity involved in translation initiation. Canadian Society for Molecular Biosciences (CSMB) 2017, Ottawa, Canada.

    2017 - View publication details

  5. Samanfar, B., Molnar, S.J., Charette, M., Schoenrock, A., Dehne, F., Golshani, A., Belzile, F., Cober, E.R. (2017). Mapping and identification of a potential candidate gene for a novel maturity locus, E10, in soybean. Theoretical and Applied Genetics (TAG), [online] 130(2), 377-390. http://dx.doi.org/10.1007/s00122-016-2819-7

    2017 - View publication details

  6. Samanfar B: Identification of Novel Maturity locus “E10” in Soybeans, Ontario Soybean and Canola Committee, London, ON, Canada, 19th Jan-2017.

    2017 - View publication details

  7. Samanfar B, Shostak K, Moteshareie H, Hajikarimlou M, Shaikho S, Omidi K,
    Hooshyar M, Burnside D, Márquez IG, Kazmirchuk T, Naing T, Ludovico P, York-Lyon
    A, Szereszewski K, Leung C, Jin JY, Megarbane R, Smith ML, Babu M, Holcik M,
    Golshani A. The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic
    acid is influenced by DOM34 and RPL36A. PeerJ. 2017 Nov 14;5:e4037.

    2017 - View publication details

  8. Gagarinova, A., Stewart, G., Samanfar, B., Phanse, S., White, C.A., Aoki, H., Deineko, V., Beloglazova, N., Yakunin, A.F., Golshani, A., Brown, E.D., Babu, M., Emili, A. (2016). Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery. cell reports, [online] 17(3), 904-916. http://dx.doi.org/10.1016/j.celrep.2016.09.040

    2016 - View publication details

  9. Shaikho S, Dobson CC, Naing T, Samanfar B, Moteshareie H, Hajikarimloo M,
    Golshani A, Holcik M. Elevated levels of ribosomal proteins eL36 and eL42 control
    expression of Hsp90 in rhabdomyosarcoma. Translation (Austin). 2016 Oct
    4;4(2):e1244395. doi: 10.1080/21690731.2016.1244395. PubMed PMID: 28090422.

    2016 - View publication details

  10. Samanfar B, Cober E, Charette M, Schoenrock A, Dehne F, Golshani A, Molnar S: A functional genomics approach (PIPE, Protein-protein Interaction Prediction Engine) to identify new early maturity alleles in soybean for Western Canada. Botany 2016, Savannah, USA

    2016 - View publication details

  11. Samanfar B, Schoenrock A, Dehne F, Golshani A, Cober E, Charette M, Molnar S: PIPE (Protein-protein Interaction Prediction Engine): A computational approach for comprehensive soybean functional genomics. Great Lakes Bioinformatics and the Canadian Computational Biology Conference (GLBIO/CCBC) 2016 (GLBIO/CCBC 2016 Toronto 2016/05/16 - 2016/05/19), Toronto, Canada.

    2016 - View publication details

  12. Burnside D, Moteshareie M, Galvan-Marquez I, Hooshyar M, Samanfar B, Shostak K, Omidi K, Peery H, Smith ML, and Golshani A: Use of chemical genomics to investigate the mechanism of action for inhibitory bioactive natural compounds. In G. Brahmachari (Ed.), Bioactive Natural Compounds: Biology and Chemistry. Wiley-VCH publication, 2015, 544 pages. ISBN: 978-3-527-33794-1.

    2015 - View publication details

  13. Samanfar B, Charette M, Cober E, Molnar S: Early flowering soybean: the art of mixing plant breeding, molecular biology and bioinformatics. Botany 2015 (Botany 2015 Shaw Convention Center Edmonton, Alberta 2015/07/25 - 2015/07/29), Edmonton, Canada

    2015 - View publication details

  14. Vlasblom J, Zuberi K, Rodriguez H, Arnold R, Gagarinova A, Deineko V, Kumar A,
    Leung E, Rizzolo K, Samanfar B, Chang L, Phanse S, Golshani A, Greenblatt JF,
    Houry WA, Emili A, Morris Q, Bader G, Babu M. Novel function discovery with
    GeneMANIA: a new integrated resource for gene function prediction in Escherichia
    coli. Bioinformatics. 2015 Feb 1;31(3):306-10. doi:
    10.1093/bioinformatics/btu671. PubMed PMID: 25316676; PubMed Central PMCID:
    PMC4308668.

    2015 - View publication details

  15. Samanfar B, Moteshareie H, Schoenrock A, Hooshyar M, Burnside D, Babu M, Dehne F, Golshani A: Efficient prediction of human protein-protein interactions at a global scale. 4th student/postdoc poster day in computational biology and bioinformatics, 2015, Ottawa, Canada; OISBS, 2015, Mont Tremblant, Canada.

    2015 - View publication details

  16. Jessulat M, Malty RH, Nguyen-Tran DH, Deineko V, Aoki H, Vlasblom J, Omidi K,
    Jin K, Minic Z, Hooshyar M, Burnside D, Samanfar B, Phanse S, Freywald T, Prasad
    B, Zhang Z, Vizeacoumar F, Krogan NJ, Freywald A, Golshani A, Babu M. Spindle
    Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by
    Nonhomologous End Joining. Mol Cell Biol. 2015 Jul;35(14):2448-63. doi:
    10.1128/MCB.00007-15. PubMed PMID: 25963654; PubMed Central PMCID: PMC4475915.

    2015 - View publication details

  17. Schoenrock A, Samanfar B, Pitre S, Hooshyar M, Jin K, Phillips CA, Wang H,
    Phanse S, Omidi K, Gui Y, Alamgir M, Wong A, Barrenäs F, Babu M, Benson M,
    Langston MA, Green JR, Dehne F, Golshani A. Efficient prediction of human
    protein-protein interactions at a global scale. BMC Bioinformatics. 2014 Dec
    10;15:383. doi: 10.1186/s12859-014-0383-1. PubMed PMID: 25492630; PubMed Central
    PMCID: PMC4272565.

    2014 - View publication details

  18. Omidi K, Hooshyar M, Jessulat M, Samanfar B, Sanders M, Burnside D, Pitre S,
    Schoenrock A, Xu J, Babu M, Golshani A. Phosphatase complex Pph3/Psy2 is involved
    in regulation of efficient non-homologous end-joining pathway in the yeast
    Saccharomyces cerevisiae. PLoS One. 2014 Jan 31;9(1):e87248. doi:
    10.1371/journal.pone.0087248. PubMed PMID: 24498054; PubMed Central PMCID:
    PMC3909046.

    2014 - View publication details

  19. Samanfar B, Tan le H, Shostak K, Chalabian F, Wu Z, Alamgir M, Sunba N,
    Burnside D, Omidi K, Hooshyar M, Galván Márquez I, Jessulat M, Smith ML, Babu M,
    Azizi A, Golshani A. A global investigation of gene deletion strains that affect
    premature stop codon bypass in yeast, Saccharomyces cerevisiae. Mol Biosyst. 2014
    Apr;10(4):916-24. doi: 10.1039/c3mb70501c. PubMed PMID: 24535059.

    2014 - View publication details

  20. Babu M, Arnold R, Bundalovic-Torma C, Gagarinova A, Wong KS, Kumar A, Stewart
    G, Samanfar B, Aoki H, Wagih O, Vlasblom J, Phanse S, Lad K, Yeou Hsiung Yu A,
    Graham C, Jin K, Brown E, Golshani A, Kim P, Moreno-Hagelsieb G, Greenblatt J,
    Houry WA, Parkinson J, Emili A. Quantitative genome-wide genetic interaction
    screens reveal global epistatic relationships of protein complexes in Escherichia
    coli. PLoS Genet. 2014 Feb 20;10(2):e1004120. doi: 10.1371/journal.pgen.1004120.
    PubMed PMID: 24586182; PubMed Central PMCID: PMC3930520.

    2014 - View publication details

Research facility

960 Carling Avenue
Ottawa, ON K1A 0C6
Canada

Affiliations

-Adjunct research professor, Department of Biology, Carleton University.

Language

English

Other languages

French (Intermediate); Persian (Native); Azerbaijani (Native); Turkish (Fluent)