Andre Craan, Ph.D.
1) Pre-market & Post-market Review of Biologics & biotechnological Drugs2) Risk/Benefit Assessment of Drugs
Current research and/or projects
Pharmacovigilance & monitoring of emerging pathogens and therapeutic technologies
Professional activities / interests
1) Post-market surveillance, signalling and assessment of adverse drug reactions
2) Evaluation of research on efficacy testing of antimicrobial agents for use on environmental surfaces and medical devices for regulatory purpose
3) Health hazard evaluation of marketed disinfectant products
4) Human health risk assessment of phthalate plasticizers in commercial products
5) Study of potential contribution of the increased use of biocides to antibiotic resistance
Education and awards
Education:
Certified Safety Assessor Cosmetics in the EU, University of Brussels 2001
Certificate Public Administration, University of Ottawa 1996
DESS Toxicology School of Graduate Studies, University of Montreal 1986
Ph. D. Physiology, University of Montreal 1977
M. S. Biology, Portland State University 1971
B. S. Biology - Minor in Chemistry, Portland State University 1969
B.A. Arts and Letters, St-Martial College, Haiti, W.I. 1965
Post-doctoral Training:
Post-doctoral Fellow Genetics Unit, Shriners’ Hospital of Montreal, McGill Univ. 1977-79
Post-doctoral Fellow Dept. Clinical Biochemistry, Banting Institute, U of T 1976-77
Awards and Grants:
Best Poster Award at the Health Canada Science Forum 2012
PSU Outstanding International Alumni Award, http://www.pdx.edu/alumni/psu-salutes 2011
ADM Excellence Award for Collaborative Leadership in the H1N1 Team 2009
Health Canada Outstanding Mentor 2008
DM Award for contributing to HC science & policy on phthalate (DINP) plasticizers 1998
Canadian Biotechnology Strategy $98,000 1999-2000
Medical Research Council of Canada $87,414 1986-88
Quebec Occupational Safety and Health Institute (IRSSTQ) $84,000 1982-84
Post-doctoral fellow of Quebec Ministry of Education & Shriners of North America 1976-79
Doctoral scholarship from the Quebec Ministry of Education 1974-76
Undergraduate and graduate scholarships from the State of Oregon, USA 1966-71
Institute of International Education-related student, 800, United Nations Plaza, NY 1966-67
International experience and/or work
2002-2009: Organisation for Economic Co-operation and Development (OECD) for Hard Surface Disinfectants: Validation Management Group on Harmonized Test Methodologies
Regular Peer-Reviewer for scientific & medical journals, e.g., 1) Pediatrics, 2) Archives of Environmental Contamination and Toxicology
Professional Memberships/Affiliations:
Drug Information Association (DIA) 2012-present
Society of Toxicology of Canada 2003-present
Association for Professionals in Infection Control and Epidemiology 2003-2004
American College of Toxicology 1999-present
American Association for the Advancement of Science 1992-94
Association des biologistes du Québec 1988-2002
Pan American Medical Association, Nephrology Council 1988-93
New York Academy of Sciences 1985-93
American Society of Nephrology 1983-93
American Federation for Clinical Research, U.S.A. 1982-93
Club de recherches cliniques du Québec 1979-93
Association canadienne-francaise pour l'avancement des sciences 1973-96
Key publications
Top 10 PUBLICATIONS
CRAAN AG, CHISHOLM IA, WRIGHT SC. Regulatory authorization of hard surface disinfectants in Canada, In: Russell, Hugo & Ayliffe's Principles and practice of disinfection, preservation and sterilization, 5th edition, Wiley-Blackwell Publishing Ltd, Oxford, Book Chapter, 2013.
GILL US, CRAAN AG, SUBRAMANIAN KS, CHU I. Chemistry, environmental path and toxicology of diisononyl phthalate. Review of Environmental Contamination and Toxicology 172: 87-127, 2001.
CRAAN AG. Toxicologie: méthodes et applications. 47 chapitres/chapters, 727 pages. ISBN 0-9737375-1-4, Webber Training Inc., Belleville, Ontario, K8N 4K6.
CRAAN AG, HAINES DA. Twenty-five years of surveillance for contaminants in human breast milk. Archives of Environmental Contamination and Toxicology 35: 702-710, 1998.
CRAAN AG, MYRES AW, GREEN DW. Hazard assessment of boric acid in toys. Regulatory Toxicology and Pharmacology 26: 271-280, 1997.
CRAAN AG, SANFAÇON G, WALKER RH. The use of pH and acid/alkaline reserve for the classification and labelling of consumer products: data from a poison control center. International Journal for Consumer Safety 4: 191-213, 1997.
CRAAN AG. Aspiration hazard and consumer products: A review. International Journal for Consumer Safety 3: 153-164, 1996.
CRAAN AG, MALICK MA. Structure-nephrotoxicity relationships of glutathione pathway intermediates derived from organic solvents. Toxicology 56: 47-61, 1989.
CRAAN AG. Renal excretory function in alligators infused with acetazolamide. Comparative Biochemistry and Physiology 78A: 243-248, 1984.
CRAAN AG, LEMIEUX G, VINAY P, GOUGOUX A. The kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies. Kidney International 22: 103-111, 1982
OTHER PUBLICATIONS IN PEER-REVIEW JOURNALS
CRAAN AG, BERGERON M. Experimental cystinuria: The cycloleucine model. I. Amino acid interactions in renal and intestinal epithelia. Canadian Journal of Physiology and Pharmacology 53: 1027-1036, 1975.
CRAAN AG, BERGERON M. Experimental cystinuria: The cycloleucine model. II. Amino acid efflux from intestinal and renal tissues. Metabolism 27: 1613-1625, 1978.
CRAAN AG, BERGERON, M. Non-participation of extracellular glutathione in renal transport of dibasic amino acids. Canadian Journal of Physiology and Pharmacoogy 57: 1168-1171, 1979.
BAINES AD, CRAAN A, CHAN W, MORGUNOV N. Tubular secretion and metabolism of dopamine, norepinephrine, methoxytyramine and normetanephrine by the rat kidney. Journal of Pharmacology and Experimental Therapeutics 208: 144-147, 1979.
CRAAN AG. Cystinuria: The disease and its models. Life Sciences 28: 5-22, 1981.
CRAAN AG, VINAY P, LEMIEUX G, GOUGOUX A. Metabolism and transport of L-glutamine and L-alanine by renal tubules of chicken: Effects of metabolic acidosis. American Journal of Physiology 245: F142-F150,1983.
LEMIEUX G, CRAAN AG, QUENNEVILLE A, LEMIEUX C, BERKOFSKY J, LEWIS VS. Metabolic machinery of the alligator kidney. American Journal of Physiology 247: F686-F693, 1984.
CRAAN AG. In vitro bone metabolism in hypophosphatemic mice: 32P and 45Ca release from cultured calvaria. International Journal of Nuclear Medicine and Biology. 11: 27-31, 1984.
CRAAN AG, NADON G, P'AN AYS. Lead flux through the kidney and salivary glands of rats. American Journal of Physiology 247: F773-F783, 1984.
CRAAN AG, MALICK MA, P'AN AYS. Segmental and intracellular distribution of lead in rat kidney and salivary glands. Toxicology 42: 157-170, 1986.
BRODEUR J, P'AN AYS, CRAAN AG. La signification du plomb présent dans la salive. Travail et santé pp. 530-533, 1985.
CRAAN AG, ALARCIA-RODRIGUEZ P. Le syndrome de l'huile toxique: étiopathologie, hypothèses et mécanismes. L'Union Médicale du Canada 116: 32-39, 1987.
CRAAN AG. Cystinuria in rats. Comparative Pathology Bulletin 19 (4): 3-4. Also published in Handbook: Animal Models of Human Disease, Registry of Comparative Pathology. Armed Forces Institute of Pathology, Washington, D.C. 1988.
CRAAN AG. Toxicologic aspects of Voodoo in Haiti. Biomedical and Environmental Sciences 1: 372-381, 1988
REPORTS
CRAAN AG. Price and Availability Study of Commercial Contraceptives in Canada: Recommendations for Aid to Third-World Countries. Report to the Canadian International Development Agency through LARECO Ltd, Contracting Agent, St-Basile-Le-Grand, Quebec. First edition. 92 pages 1984.
P'AN AYS, CRAAN AG. Évaluation biologique. In: Étude des Problèmes de Santé dans une Industrie de Transformation des Plastiques. L. de Guire, ed. Mc Gill University, Montreal, pages 29-62 1985.
CRAAN AG. Price and Availability Study of Commercial Contraceptives in Canada: Recommendations for Aid to Third-World Countries. Report to the Canadian International Development Agency through SIGESCO Ltd, Contracting Agent, St-Basile-Le-Grand, Quebec. Second edition. 249 pages 1990.
STAFF OF THE GREAT LAKES HEALTH EFFECTS PROGRAM including CRAAN, A.G. Health-Related Indicators for the Great Lakes Basin Population: Numbers 1 to 20. Health Canada, Minister of Public Works and Government Services, Ottawa. Catalogue No. H46-2/98-219E 1998.
O’NEILL J, BAKER C, CRAAN AG. Risk/Benefit Perceptions of Biotechnology Products. Prepared for Health Canada by Environics Research Group. CRAAN, A.G., Project Manager, Ottawa 2000.
CHHIL M, CRAAN AG (Chair), HINBERG I, LALONDE PJ, LO M-T, MACPHERSON H, MATULA T, MORRISON H, POON R, Roussel S, Sensenstein R. Issue Identification Paper on Phthalate Plasticizers. The Science Team of the Inter-Branch Working Group of Plasticizers. Health Products and Food, Healthy Environments and Consumer Safety, and Population and Public Health Branches Health Canada, Ottawa, ON, July 25, 2002.
8 STANDARDS WRITINGS
BENNER HJ, CRAIG W, CRAAN AG et al. Canadian General Standards Board Committee on Construction and Maintenance Coatings 1997-1998
BOOKS
CRAAN AG. Un Héritage à valoriser: écologie, toxicologie et développement en Haiti. Les éditions du CIDIHCA, Montreal, Canada. 172 pages 1988.
CRAAN AG. Toxicologie: méthodes et applications, 726 pages 2005, published as a compact disk athttp://webbertraining.com, Belleville, ON, Canada.
Contact
Expertise
Affiliations
Health Canada