Research on antibiotic resistance, antifungal resistance, nosocomial infections and genomics
Current research and/or projects
Research focusing on genomic epidemiology and mechanisms of antimicrobial resistance of various bacterial and fungal pathogens, including Enterobacteriales and Candida.
Research and/or project statements
Research intersets include:
- antimicrobial resistant bacterial and fungal pathogens
- mechanisms of antimicrobial resistance
- genomic epidemiology
- genomics-based innovation including WGS from clinical specimens and prediction of resistance from WGS
Education and awards
Ph.D. Biochemistry and Biomedical Sciences, McMaster University
B.Sc. Biochemistry and Molecular Biology, McMaster University
NSERC Visiting Fellowship in a Canadian Government Lab
CIHR Frederick Banting and Charles Best Canada Graduate Scholarship ($70,000)
Ontario Graduate Scholarship
Mulvey, M.R., Bharat, A., Boyd, D.A., Irwin, R.J., Wylie, J. Characterization of a colistin-resistant Salmonella enterica 4, ,12: I: - Harbouring mcr-3.2 on a variant IncHI-2 plasmid identified in Canada 2018 Journal of Medical Microbiology 67(12),000854, pp. 1673-1675.
Walkty, A., Adam, H., Tran, V., (...), Bharat, A., Karlowsky, J. Failure of a multiplex polymerase chain reaction assay to detect IMP-27 in a clinical isolate of Morganella morganii 2018 Diagnostic Microbiology and Infectious Disease, 92(3), pp. 194-195.
Bharat, A., Martin, I., Zhanel, G.G., Mulvey, M.R. In vitro potency and combination testing of antimicrobial agents against Neisseria gonorrhoeae 2016 Journal of Infection and Chemotherapy, 22(3), pp. 194-197.
French, S., Mangat, C., Bharat, A., (...), Mori, H., Brown, E.D. A robust platform for chemical genomics in bacterial systems, 2016 Molecular Biology of the Cell, 27(6), pp. 1015-1025.
Bharat, A., Martin, I., Demczuk, W., (...), Hoang, L., Mulvey, M.R. Complete genome sequences of Neisseria gonorrhoeae with coresistance to first-line antimicrobials, 2016 Genome Announcements 4(5),e00966-16.
Bharat, A., Demczuk, W., Martin, I., Mulvey, M.R. Effect of variants of penicillin-binding protein 2 on cephalosporin and carbapenem susceptibilities in Neisseria gonorrhoeae. 2015 Antimicrobial Agents and Chemotherapy, 59(8), pp. 5003-5006.
Bharat, A., Brown, E.D. Phenotypic investigations of the depletion of EngA in Escherichia coli are consistent with a role in ribosome biogenesis. 2014 FEMS Microbiology Letters, 353(1), pp. 26-32.
Mangat, C.S., Bharat, A., Gehrke, S.S., Brown, E.D. Rank ordering plate data facilitates data visualization and normalization in high-throughput screening. 2014 Journal of Bimolecular Screening, 19(9), pp. 1314-1320.
Mangat, C. S., Bharat, A., Gehrke, S. S., & Brown, E. D. Rank ordering plate data facilitates data visualization and normalization in high-throughput screening. 2014 Journal of biomolecular screening, 19(9), 1314–1320.
Bharat, A., Blanchard, J. E., & Brown, E. D. (2013). A High-Throughput Screen of the GTPase Activity of Escherichia coli EngA to Find an Inhibitor of Bacterial Ribosome Biogenesis. Journal of Biomolecular Screening, 18(7), 830–836.
Bharat, A., Jiang, M., Sullivan, S.M., Maddock, J.R., Brown, E.D. Cooperative and critical roles for both G domains in the GTPase activity and cellular function of ribosome-associated Escherichia coli EngA. 2006 Journal of Bacteriology,188(22), pp. 7992-7996.