Sandra Clarke, Ph.D.

Image Sandra Clarke
Research Scientist

Human Health and Nutrition

Current research and/or projects

Dr. Clarke’s research has been focused on investigating the impacts of dietary supplements and food components on gut health and microbiota. Dr. Clarke’s work is linked to the AAFC strategic area of improving attributes for food and non-food uses; and continues to explore food ingredients for potential to decrease inflammation, maintain a balanced intestinal microbial community structure and support overall health. 

Research and/or project statements

  • Establishing a research program to characterize the effects of food ingredients on gut health using mammalian models
  • Investigating feasibility of incorporating waste products from cereal and horticultural processing into functional food products, quantifying and characterizing bioactives and subsequent impacts on gut health

Professional activities / interests

  • Investigations of dietary interventions and supplements (dietary fibre, fats) on gut health, immunity and microbiome community structure
  • Characterizing diet related alterations to intestinal inflammation and gut health
  • Value-added ingredients to maintain or promote gut health

Education and awards

Doctor of Philosophy, Applied Bioscience – Immunology, University of Ontario Institute of Technology, 2016



Bescucci D, Clarke ST, Brown CLJ, Boras VF, Montina T, Uwiera RRE & Inglis GD. 2020. The murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathogens 12:53.

Sarfaraz S, Singh S, Hawke A, Clarke ST & Ramdath DD. 2020. Effects of high-fat diet induced obesity and fructooligosaccharide supplementation on cardiac protein expression. Nutrients 12(11):3404.

Gourgouvelis J, Yielder P, Clarke ST, Behbahani H & Murphy BA. 2018. Exercise leads to better clinical outcomes in those receiving medication plus cognitive behavioural therapy for major depressive disorder. Frontiers in Psychiatry 9:37.

Gourgouvelis J, Yielder P, Clarke ST, Behbahani H & Murphy BA. 2018. You can’t fix what isn’t broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults. PeerJ 6: e4675.

Clarke ST, Brooks SPJ, Inglis GD, Yanke LJ, Green J, Pertonella N, Ramdath DD, Bercik P, Green-Johnson JM & Kalmokoff. 2017. Impact of β2-1 fructan on the faecal community change: results from a placebo-controlled, randomized, double-blinded, cross-over study in healthy adults. British Journal of Nutrition 118(6): 441-453.

Clarke ST, Green-Johnson JM, Brooks SPJ, Ramdath DD, Bercik P, Avila C, Inglis GD, Green J, Yanke LJ, Selinger LB & Kalmokoff ML. 2016. β2-1 Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults. British Journal of Nutrition 115(10): 1748-1759.

McCarville JL, Clarke ST, Shastri P, Liu Y, Kalmokoff ML, Brooks SPJ & Green-Johnson JM. 2013. Spaceflight Influences both Mucosal and Peripheral Cytokine Production in PTN-Tg and Wild Type Mice. PLoS One 8(7): e68961.

Research facility

93 Stone Road West
Guelph, ON N1G 5C9


  • Adjunct Professor, Faculty of Science and Applied Bioscience Graduate Program, Ontario Tech University
  • American Association of Immunologists (member)